A5088775983- Toxic Organic Pollutants Impact
- Environmental Toxicology and Ecotoxicology
- Mercury impact and mitigation studies
- Effects and risks of endocrine disrupting chemicals
- Fish Ecology and Management Studies
- Air Quality and Health Impacts
- Aquaculture Nutrition and Growth
- Reproductive biology and impacts on aquatic species
- Atmospheric and Environmental Gas Dynamics
- Ocean Acidification Effects and Responses
- Oil Spill Detection and Mitigation
- Marine Biology and Environmental Chemistry
- Electrochemical Analysis and Applications
- Carcinogens and Genotoxicity Assessment
- Microplastics and Plastic Pollution
- Pharmaceutical and Antibiotic Environmental Impacts
- Advanced Statistical Process Monitoring
- Marine and coastal ecosystems
- Mitochondrial Function and Pathology
- Groundwater flow and contamination studies
- Marine and fisheries research
- Analytical Chemistry and Chromatography
- Pesticide and Herbicide Environmental Studies
- Microbial bioremediation and biosurfactants
- Mass Spectrometry Techniques and Applications
Norwegian Institute of Marine Research
2019-2025
Oregon State University
2015-2019
Institute of Fisheries and Aquaculture
2019
Wristbands are increasingly used for assessing personal chemical exposures. Unlike some exposure assessment tools, guidelines wristbands, such as preparation, applicable chemicals, and transport storage logistics, lacking. We tested the wristband's capacity to capture retain 148 chemicals including polychlorinated biphenyls (PCBs), pesticides, flame retardants, polycyclic aromatic hydrocarbons (PAHs), volatile organic (VOCs). The span a wide range of physical–chemical properties, with log...
We detected between 2 and 10 pesticides per person with novel sampling devices worn by 35 participants who were actively engaged in farming Diender, Senegal. Participants recruited to wear silicone wristbands for each of two separate periods up 5 days. Pesticide exposure profiles highly individualized only limited associations demographic data. Using a 63-pesticide dual-column gas chromatography-electron capture detector (GC-ECD) method, we pyrethoid insecticides most frequently, followed...
As Arctic ice recedes, future oil spills pose increasing risk to keystone species and the ecosystems they support. We show that Polar cod (Boreogadus saida), an energy-rich forage fish for marine mammals, seabirds, other fish, are highly sensitive developmental impacts of crude oil. Transient exposures ≥300 μg/L during mid-organogenesis disrupted normal patterning jaw as well formation function heart, in a manner expected be lethal post-hatch larvae. More importantly, we found exposure lower...
Natural gas extraction, often referred to as "fracking", has increased rapidly in the United States recent years. To address potential health impacts, passive air samplers were deployed a rural community heavily affected by natural boom. Samplers analyzed for 62 polycyclic aromatic hydrocarbons (PAHs). Results grouped based on distance from each sampler nearest active well. Levels of benzo[a]pyrene, phenanthrene, and carcinogenic potency PAH mixtures highest when closest wells. levels...
Polycyclic aromatic hydrocarbons (PAHs) are toxic contaminants with a widespread presence in diverse environmental contexts. Transformation processes of PAHs via degradation and biotransformation have parallels humans, animals, plants, fungi, bacteria. Mapping the transformation products is therefore crucial for assessing their toxicological impact developing effective monitoring strategies. The present research aimed to explore PAH detoxification formed by marine fish Atlantic haddock...
Early life stages of fish are highly sensitive to crude oil exposure and thus, short term exposures during critical developmental periods could have detrimental consequences for juvenile survival. Here we administered Atlantic haddock (Melanogrammus aeglefinus) in (3-day) at two time periods: before first heartbeat, from gastrulation cardiac cone stage (early), heartbeat one day hatching (late). A frequent sampling regime enabled us determine immediate PAH uptake, metabolite formation gene...
A multitude of recent studies have documented the detrimental effects crude oil exposure on early life stages fish, including larvae and embryos. While polycyclic aromatic hydrocarbons (PAHs), particularly alkyl PAHs, are often considered main cause observed toxic effects, other derived organic compounds usually overlooked. In current study, comprehensive two-dimensional gas chromatography coupled to mass spectrometry was applied investigate body burden a wide range petrogenic in Atlantic...
Atlantic haddock (Melanogrammus aeglefinus) embryos bind dispersed crude oil droplets to the eggshell and are consequently highly susceptible toxicity from spilled oil. We established thresholds for developmental identified any potential long-term or latent adverse effects that could impair growth survival of individuals. Embryos were exposed eight days (10, 80 300 μg oil/L, equivalent 0.1, 0.8 3.0 TPAH/L). Acute delayed mortality observed at embryonic, larval, juvenile stages with IC50 =...
Polycyclic aromatic hydrocarbons (PAHs) have frequently been suspected of governing crude oil toxicity because similar morphological defects in fish. However, PAH concentrations are often not high enough to explain the observed toxicity. We hypothesize that one can enhance metabolism and another when administered as a mixture. Early life stage Atlantic haddock (Melanogrammus aeglefinus) were this study exposed phenanthrene presence absence 3-methylchrysene is known induce metabolic enzyme...
Natural gas extraction, often referred to as "fracking," has increased rapidly in the U.S. recent years. To address potential health impacts, passive air samplers were deployed a rural community heavily affected by natural boom. Samplers analyzed for 62 polycyclic aromatic hydrocarbons (PAHs). Results grouped based on distance from each sampler nearest active well. PAH levels highest when closest wells. Additionally, activity an order of magnitude higher than previously reported areas....
The research objective was to study the presence of DNA damages in haddock exposed petrogenic or pyrogenic polyaromatic hydrocarbons (PAHs) from different sources: 1) extracts oil produced water (PW), dominated by 2-ring PAHs; 2) distillation fractions crude (representing oil-based drilling mud), 3-ring 3) heavy PAHs, mixture 4/5/6-ring PAHs. biological effect PAH sources studied feeding juvenile with low doses PAHs (0.3–0.7 mg PAH/kg fish/day) for two months, followed a two-months recovery....
Tricyclic polycyclic aromatic hydrocarbons (PAHs) are believed to be the primary toxic components of crude oil. Such compounds including phenanthrene known have direct effects on cardiac tissue, which lead malformations during organogenesis in early life stage fish. We tested a suite 13 alkyl-phenanthrenes compare uptake and developmental toxicity haddock (Melanogrammus aeglefinus) embryos gastrulation/organogenesis beginning at 2 days post fertilization via passive dosing. The were their...
This work uses passive samplers to identify PAHs and OPAHs not previously associated with artificial turf, provide the first quantitative measure of in situ flux semi-volatile contaminants on turf fields. Both air (1.5-m height) (immediately above surface) were sampled using two sampling materials: low-density polyethylene silicone. Utilizing a broad targeted screen, we assess both samples crumb rubber for over 1530 chemicals including pesticides, phthalates, personal care products. We...
To further understand the complexity of developmental toxicity dispersed oil and importance exposure timing on fish early life stages, Atlantic halibut (Hippoglossus hippoglossus) were exposed to environmentally relevant concentrations through two embryonic windows: first period occurred during epiboly process (named as "early exposure") second overlapped ontogenesis cardiogenesis processes "late exposure"). Following 72 hour exposure, embryos transferred clean seawater a screening was...
Crude oil causes severe abnormalities in developing fish. Photomodification of constituents crude increases its toxicity several fold. We report on the effect oil, combination with ultraviolet (UV) radiation, Atlantic haddock (Melanogrammus aeglefinus) embryos. Accumulation eggshell makes embryos particularly susceptible to exposure. At high latitudes, they can be exposed UV radiation many hours a day. Haddock were (5-300 μg oil/L nominal loading concentrations) for three days presence and...
Developing organisms are especially vulnerable to environmental stressors. Crude oil exposure in early life stages of fish result multiple functional and developmental defects, including cardiac dysfunction abnormal smaller eyes. Phenanthrene (Phe) has a reversible impact on function, under Phe reduces contractility. Exposure known L-type channel blocker, nicardipine hydrochloride (Nic) also disrupts function creates eye deformities. We aimed investigate whether was the major underlying...
The aryl hydrocarbon receptor (Ahr) is a ligand-activated transcription factor that mediates the toxicity of dioxins and dioxin-like compounds (DLCs) in vertebrates. Two clades Ahr family exist teleosts (Ahr1 Ahr2), it has been demonstrated Ahr2 main protein involved mediating DLCs most teleost species. Recently, we characterized Atlantic cod (Gadus morhua) Ahr1a Ahr2a receptors. To further explore possible subfunction partitioning have mapped expression localization ahr1a ahr2a early...
Photo-enhanced toxicity of crude oil is produced by exposure to ultraviolet (UV) radiation. Atlantic cod (Gadus morhua) embryos were exposed with and without UV radiation (290-400 nm) from 3 days post fertilization (dpf) until 6 dpf. Embryos the co-exposure experiment continually hatching at 11 Differences in body burden levels cyp1a expression observed between regimes. High doses increased mortality co-exposed embryos, as well craniofacial malformations heart deformities larvae both...
Complex mixtures like crude oil, and single components such as Phenanthrene (Phe), induce cardiotoxicity by interfering with excitation-contraction coupling. However, recent work has demonstrated that the timing of pollutant exposure during embryogenesis greatly impacts degree cardiac dysfunction caused. Here, we aimed to clarify temporal dependence Phe toxicity downstream effects using Atlantic cod (Gadus morhua). (nominal concentration, 1.12 μmol/L), or L-type‑calcium channel blocker...
Most of the polycyclic aromatic hydrocarbons (PAHs) in petroleum are alkylated (alkyl PAHs), still metabolism these alkyl PAHs to expected acid products (polycyclic acids; PAAs) has yet be demonstrated oil-exposed fish. Should compounds discovered fish as they have ragworm, rodents, and humans, could present an indicative biomarker for assessing oil pollution. In this study, ability biotransform PAAs was examined on Atlantic haddock (Melanogrammus aeglefinus). Exposure phenanthrene,...
Fish exposed to xenobiotics like petroleum-derived polycyclic aromatic hydrocarbons (PAHs) will immediately initiate detoxification systems through effective biotransformation reactions. Yet, there is a discrepancy between recognized metabolic pathways and the actual metabolites detected in fish following PAH exposure oil pollution. To deepen our understanding of detoxification, we conducted experiments exposing Atlantic haddock (
Pacific herring (Clupea pallasii), a cornerstone of marine food webs, generally spawn on macroalgae in shallow nearshore areas that are disproportionately at risk from oil spills. Herring embryos also highly susceptible to toxicity chemicals leaching stranded intertidal and subtidal zones. The water-soluble components crude trigger an adverse outcome pathway involves disruption the physiological functions cardiomyocytes embryonic heart. In previous studies, impaired ionoregulation (calcium...
Laboratory experiments provide knowledge of species-specific effects thresholds that are used to parameterize impact assessment models oil contamination on marine ecosystems. Such typically place individuals species and life stages in tanks with different contaminant concentrations. Exposure concentrations usually fixed, the experience a shock treatment being moved from clean water directly into contaminated then back water. In this study, we use coupled numerical model simulates ocean...