A5058983184- Insect symbiosis and bacterial influences
- Genomics and Phylogenetic Studies
- Vector-borne infectious diseases
- Parasitic Infections and Diagnostics
- Plant Pathogenic Bacteria Studies
- Insect-Plant Interactions and Control
- Veterinary medicine and infectious diseases
- Clostridium difficile and Clostridium perfringens research
- Bacterial Identification and Susceptibility Testing
- CRISPR and Genetic Engineering
- Congenital Diaphragmatic Hernia Studies
- Photosynthetic Processes and Mechanisms
- Genetic diversity and population structure
- Viral Infections and Vectors
- Microbial Metabolism and Applications
- Antimicrobial Resistance in Staphylococcus
- Protist diversity and phylogeny
- Neonatal Respiratory Health Research
- Mosquito-borne diseases and control
- Antibiotic Resistance in Bacteria
- Insect and Pesticide Research
- Pregnancy and preeclampsia studies
University of Pavia
2020-2024
University of Milan
2021-2024
Many animals are dependent on microbial partners that provide essential nutrients lacking from their diet. Ticks, whose diet consists exclusively vertebrate blood, rely maternally inherited bacterial symbionts to supply B vitamins. While previously studied tick species consistently harbor a single lineage of those nutritional symbionts, we evidence here the invasive Hyalomma marginatum harbors unique dual-partner system between an ancestral symbiont, Francisella , and more recently acquired...
The order Rickettsiales (Alphaproteobacteria) encompasses multiple diverse lineages of host-associated bacteria, including pathogens, reproductive manipulators, and mutualists. Here, in to understand how intracellularity host association originated this order, whether they are ancestral or convergently evolved characteristics, we built a large phylogenetically-balanced dataset that includes de novo sequenced genomes selection published genomic metagenomic assemblies. We perform detailed...
Members of the bacterial order Rickettsiales are obligatorily associated with a wide range eukaryotic hosts. Their evolutionary trajectories, in particular concerning origin shared or differential traits among distant sub-lineages, still poorly understood. Here, we characterized novel bacterium ciliate Paramecium tredecaurelia and phylogenetically related to Rickettsia genus. Its genome encodes significant lineage-specific features, chiefly mevalonate pathway gene repertoire, involved...
Infants with congenital diaphragmatic hernia (CDH) are at high risk of postnatal mortality due to lung hypoplasia and arterial pulmonary hypertension. In severe cases, prenatal intervention by fetal endoscopic tracheal occlusion (FETO) can improve survival accelerating growth. However, remains in the range about 50% despite treatment, there is currently no clear explanation for this different clinical response FETO. We evaluated concentration extracellular vesicles (EVs) associated microRNA...
Abstract Ticks require bacterial symbionts for the provision of necessary compounds that are absent in their hematophagous diet. Such frequently vertically transmitted and, most commonly, belong to Coxiella genus, which also includes human pathogen burnetii. This genus can be divided four main clades, presenting partial but incomplete cocladogenesis with tick hosts. Here, we report genome sequence a novel Coxiella, endosymbiont African Amblyomma nuttalli, and ensuing comparative analyses....
is an opportunistic pathogen that survives in inhospitable environments causing large outbreaks, particularly neonatal intensive care units (NICUs). Genomic studies revealed most
Wolbachia bacteria encompass noteworthy reproductive manipulators of their arthropod hosts. which influence host reproduction to favour own transmission, also exploiting toxin-antitoxin systems. Recently, multiple other bacterial symbionts arthropods have been shown display comparable manipulative capabilities. Here we wonder whether such phenomena are truly restricted We focused on protists, primary models for evolutionary investigations eukaryotes due diversity and antiquity, but still...
The zoonotic parasite
Abstract The order Rickettsiales ( Alphaproteobacteria ) encompasses multiple diverse lineages of host-associated bacteria, including pathogens, reproductive manipulators, and mutualists. In to understand how intracellularity host association originated in this order, whether they are ancestral or convergently evolved characteristics, we built an unprecedentedly large phylogenetically-balanced dataset that includes de novo sequenced genomes accurate selection published genomic metagenomic...
Abstract Many animals are dependent on microbial partners that provide essential nutrients lacking from their diet. Ticks, whose diet consists exclusively vertebrate blood, rely maternally inherited bacterial symbionts to supply B vitamins. While previously studied tick species consistently harbor a single lineage of those nutritional symbionts, we evidence here the invasive Hyalomma marginatum harbors unique dual-partner system between an ancestral symbiont, Francisella , and more recently...
Abstract Ticks require bacterial symbionts for the provision of necessary compounds that are absent in their hematophagous diet. Such frequently vertically transmitted and, most commonly, belong to Coxiella genus, which also includes human pathogen burnetii . This genus can be divided four main clades, presenting partial but incomplete co-cladogenesis with tick hosts. Here we report genome sequence a novel , endosymbiont African Amblyomma nuttalli and ensuing comparative analyses. Its size...
Serratia marcescens is an opportunistic pathogen able to cause severe and lethal infections.The bacterium survive in inhospitable environments (e.g.soap dispenser) rapidly spread among patients, causing large outbreaks, particular Neonates Care Intensive Units (NICUs).Recent genomic studies revealed that most S. nosocomial infections are caused by a specific clinical-associated clone.The timely detection of this clone environmental or clinical samples can drastically increase the efficiency...
Abstract The zoonotic parasite Cryptosporidium parvum is a global cause of gastrointestinal disease in humans and ruminants. Sequence analysis the highly polymorphic gp60 gene enabled classification C. isolates into multiple groups (e.g. IIa, IIc, Id) large number subtypes. In Europe, subtype IIaA15G2R1 largely predominant has been associated with many water-and food-borne outbreaks. this study, we generated new whole genome sequence (WGS) data from 123 human-and ruminant-derived collected...