A5065475058- SARS-CoV-2 and COVID-19 Research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- COVID-19 epidemiological studies
- Animal Virus Infections Studies
- Influenza Virus Research Studies
- Respiratory viral infections research
- vaccines and immunoinformatics approaches
- Viral gastroenteritis research and epidemiology
- Glioma Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Reproductive Biology and Fertility
- Molecular Biology Techniques and Applications
- SARS-CoV-2 detection and testing
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Lung Cancer Treatments and Mutations
- DNA Repair Mechanisms
- RNA Research and Splicing
- Mechanisms of cancer metastasis
- Sarcoma Diagnosis and Treatment
- Genetics, Bioinformatics, and Biomedical Research
- Chromatin Remodeling and Cancer
- Bladder and Urothelial Cancer Treatments
Children Cancer Hospital
2021-2025
Ministry of Health and Population
2022-2024
National Research Centre
2021-2023
Al-Azhar University
2019-2023
Kazan Federal University
2023
Damanhour University
2023
Alexandria University
2022
Ain Shams University
2022
Regeneron (United States)
2018-2021
Jilin Agricultural University
2021
Abstract Introduction Two years after unprecedented low rates of circulation most common respiratory viruses (SARS-CoV-2), the Egyptian ARI surveillance system detected an increase in acute infections (ARIs) with a reduced severe syndrome coronavirus 2 especially among school children. A national survey was conducted to estimate burden and identify viral causes ARIs children < 16 age. Methods one-day carried out 98 governmental outpatient clinics distributed all over Egypt 26...
Abstract Glioblastoma multiforme (GBM) is the most prevalent, treatment-resistant, and fatal form of brain malignancy. It characterized by genetic heterogeneity, an infiltrative nature, GBM treatment highly challenging. Despite multimodal therapies, clinicians lack efficient prognostic predictive markers. Therefore, new insights into management are urgently needed to increase chance therapeutic success. Circulating miRNAs (miRs) important regulators cancer progression potentially useful for...
Retinoic acid, vitamin A metabolite, plays a role in oocyte development and maturation different ways including gene expression alteration and/or prohibiting oxidative stress. The objective of this study was to examine the effect 9-cis-retinoic acid (9-cisRA) on quality rate buffalo oocytes. Cumulus-oocyte complexes (COCs, n = 460) were collected from ovaries slaughtered buffalos. Varying concentrations 9-cisRA (0, 5, 50, 200 nM) added medium, following parameters analyzed: (i) cleavage...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was first detected in Egypt February 2020. Data about the prevalence rates of SARS-CoV-2 lineages are relatively scarce. To understand genetic characteristics during several waves pandemic, we analyzed sequences 1256 Egyptian full genomes from March 2020 to May 2021. From one wave next, dominant strains have been observed be replaced by other strains. We an emerging lineage that shares mutations with variant concern (VOC). The...
Abstract Background The o severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic has killed millions of people and caused widespread concern around the world. Multiple genetic variants SARS-CoV-2 have been identified as continues. Concerns raised about high transmissibility lower vaccine efficacy against omicron. There is an urgent need to better describe how omicron will impact clinical presentation efficacy. This study aims at comparing epidemiologic, clinical, genomic...
In late 2022, severe acute respiratory infections (SARI) surveillance reported an abrupt increase in non-COVID-19 among children after three years of drastic reductions. Signals increased absenteeism due to symptoms primary and preparatory school were detected by Event-Based Surveillance. We conducted a hospital-based survey who admitted with SARI identify the causative pathogen(s) estimate burden infection. A was < 16 21 referral hospitals governorates highest rates. Patients' demographics,...
Abstract Viral infections of the central nervous system (CNS) are common worldwide and result in considerable morbidity mortality associated with neurologic illness. Until now, there have been no epidemiologic data regarding viruses causing aseptic meningitis, encephalitis, CNS Egypt. We investigated 1735 archived cerebrospinal fluid samples collected from Egyptian patients between 2016 2019 performed molecular characterization for infection for12 different viruses: herpes simplex 1 2 (HSV-1...
To describe the changes that occurred in SARS-CoV-2 and influenza Prevalence, epidemiology, clinical picture, prevalent genotypes among Egyptian pilgrims returning from Hajj Umrah 2022 seasons. Pilgrims were contacted at airport invited to participate survey. who consented interviewed using a standardized line list included participant demographics, respiratory symptoms if any, previous COVID-19 infection, vaccination whereas information collected cards. Participants asked provide throat...
Background and objectives Human rotavirus (RV) is the main cause of diarrheal disease among children younger than 5 years old, worldwide. The aim current study was to investigate prevalence RV infections genotype distribution in Egypt. Materials methods A total 642 fecal samples were collected from age, suffering acute diarrhea attending ten regional public hospitals ( n =585) five private clinics =57) located 6 Egyptian cities between February June 2021. All screened by...
Abstract: We present a case of human herpes virus 8 (HHV8)‐associated Kaposi sarcoma (KS) occurring in renal allograft ureter from male donor. The female patient presented with rising creatinine due to ureteric obstruction, and subsequent histological examination the excised tumor revealed KS. tested positive for HHV8 antigen and, using situ hybridization identify X Y chromosomes, we were able demonstrate that was origin. In absence any other KS lesions, this suggested arose reactivation...
COVID-19 was first diagnosed in Egypt on 14 February 2020. By the end of November 2021, over 333,840 cases and 18,832 deaths had been reported. As part national genomic surveillance, 1027 SARS-CoV-2 near whole-genomes were generated published by July 2021. Here we describe epidemiology this period using a subset 976 high-quality Egyptian genomes analyzed together with representative set global sequences within phylogenetic framework. A single lineage, C.36, introduced early pandemic...
Hypoxia accompanies many human diseases and is an indicator of tumor aggressiveness. Therefore, measuring hypoxia in vivo clinically important. Recently, complexes calix[4]arene were identified as potent markers. The subject this paper new hypoxia-sensitive host–guest thiacalix[4]arene. We report a high-yield synthesis method for thiacalix[4]arene with four anionic carboxyl azo fragments on the upper rim (thiacalixarene L) assessment thiacalixarene L most widespread cationic rhodamine dyes...
Abstract COVID-19 was first diagnosed in Egypt on 14 February 2020. By the end of November 2021, over 333,840 cases and 18,832 deaths had been reported. As part national genomic surveillance, 1,027 SARS-CoV-2 near whole-genomes generated published by May 2021. Here we describe epidemiology this period using a subset 976 high-quality Egyptian genomes analysed together with representative set global sequences within phylogenetic framework. We show that single lineage, C.36, introduced early...
Ramadan Umrah is the second largest Islamic pilgrimage with 2.75 million pilgrims allowed in 2022. This report presents results of a survey among Egyptian returning from to monitor SARS-CoV-2 and influenza activity identify prevalent variants after this mass gathering.
Monkeypox virus has recently been detected in multiple countries. Two cases of monkeypox were reported Egypt as part an ongoing international outbreak. We report the whole-genome sequence a that was retrieved from first confirmed case Egypt. The fully sequenced on Illumina platform, and phylogenetic analysis demonstrated current strain is closely related to clade IIb, which caused recent multicountry outbreaks.
Germ line mutations of BRCA1 and BRCA2 were correlated with a variety cancer Authors aimed to use next-generation sequencing (NGS) detect germ in glioblastoma multiform (GBM) Egyptian patients.Genomic DNA was extracted from six GBM cases, amplified using Ion AmpliSeq panel. libraries pooled, barcoded finally sequenced Torrent Personal Genome Machine sequencer.BRCA1 the previously reported rs1799966, rs1799950, rs16941 found five cases they are linkage disequilibrium forming two distinct...
Self-service technology (SST) is continuously improving to make a wide range of services easier, quicker, and more suitable.The current study aims mainly explore customers' acceptance intention use SST in five-star hotels Egypt based on its ease usefulness.Therefore, the research highlighted four issues SST, namely; (perceived usefulness use), readiness (innovativeness, optimism, discomfort, insecurity), characteristics (responsiveness smartness), SST.Five main hypotheses were developed...
A 44-year-old haemodialysis patient was admitted for a cadaveric renal transplant. The donor artery (from 38-year-old female who died of subarachnoid haemorrhage) found on dissection to have thinwalled saccular aneurysm, measuring approximately 10mm in diameter (Figure 1) which ressected with end-to-end branch reanastomosis. kidney functioned well, no complications at the time writing. There suggestion that this either an inflammatory or mycotic aneurysm. Saccular non-atherosclerotic...
<b>Introduction</b>: Autophagy was found to play a major role in the pathogenesis of acute lymphoblastic leukemia (ALL). In this study we investigated expression beclin-1, Bad, Bax, Bcl-2, and Bcl-xL patients with ALL. <br /> <b>Material methods</b>: This comparative conducted on 100 ALL (age 8–15) divided into 2 groups. The first group, comprised cases at their initial diagnosis (46 patients), while second Remission in-remission (50 patients). mRNA levels...
Glioblastoma (GBM) is an aggressive primary brain tumor prevalent in adults, characterized as a common malignant neoplasm of the human central nervous system with worst survival rate among cancers. Treatment GBM involves addition alkylating agent temozolomide (TMZ) to radiotherapy, which improves overall by preventing replication through alkyl group-mediated DNA cross-linking. Genes related homologous recombination (HR)-dependent repair, such breast cancer susceptibility genes (BRCA),...