A5058129950- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- S100 Proteins and Annexins
- Ocular Oncology and Treatments
- RNA Research and Splicing
- Thyroid Cancer Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Neuroendocrine Tumor Research Advances
- Ear and Head Tumors
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Calpain Protease Function and Regulation
- Biofuel production and bioconversion
- Plant Molecular Biology Research
- Polysaccharides and Plant Cell Walls
- Lung Cancer Research Studies
The Ohio State University
2018-2025
Background: Medullary thyroid cancer (MTC) is a frequently metastatic tumor of the that develops from malignant transformation C-cells. These tumors most commonly have activating mutations within RET or RAS proto-oncogenes. Germline result in C-cell hyperplasia, and cause MTC pre-disposition disorder, multiple endocrine neoplasia, type 2A (MEN2A). Single-agent therapies for MTC, including vandetanib (VAN) cabozantinib all MTCs selpercatinib (SEL) RET-mutated lead to partial responses but are...
Retinoblastoma is a rare pediatric tumor of the retina, caused by homozygous loss 1 (RB1) suppressor gene. Previous microarray studies have identified changes in expression profiles coding genes, however our understanding how non-coding genes change this tumor, absent. This an important area research, as many adult malignancies, including LNC-RNAs are used biomarkers to predict outcome and/or relapse. To establish complete, and in-depth RNA profile, both tumors, we conducted RNA-seq from...
MENIN is a scaffold protein encoded by the MEN1 gene that functions in multiple biological processes, including cell proliferation, migration, expression, and DNA damage repair. tumor suppressor gene, mutations disrupts function are common to many types. Mutations within may also be inherited (germline). Many of these associated with number pathogenic syndromes parathyroid pancreas, some predispose patients hyperplasia. In this study, we cataloged reported germline from ClinVar database...
Worldwide, the number of cancer-related deaths continues to increase due ability cancer cells become chemotherapy-resistant and metastasize. For women with ovarian cancer, a staggering 70% will resistant front-line therapy, cisplatin. Although many mechanisms cisplatin resistance have been proposed, key such remain elusive. The RNA binding protein multiple splicing (RBPMS) binds nascent transcripts regulates splicing, transport, localization, stability. Evidence indicates that RBPMS also...
Retinoblastoma is rare tumor of the retina caused by homozygous loss 1 suppressor gene (RB1). Loss RB1 protein, pRB, results in de-regulated activity E2F transcription factors, chromatin changes and developmental defects leading to development. Extensive microarray analyses these tumors have enabled identification genes sensitive pRB disruption however this technology has a number limitations mRNAs profiles which they generate. The advent RNA-sequencing global profiling all RNA within cell...
DICER1 syndrome is a cancer pre-disposition disorder caused by mutations that disrupt the function of in miRNA processing. Studying molecular, cellular and oncogenic effects these can reveal novel mechanisms control cell homeostasis tumor biology. Here, we conduct first analysis pathogenic allele from 3'UTR. We find allele, rs1252940486, abolishes interaction with PUMILIO RNA binding protein 3'UTR, resulting degradation mRNA AUF1. This single mutational event leads to diminished levels,...
Inactivation of RB is one the hallmarks cancer, however gaps remain in our understanding how RB-loss changes human cells. Here we show that pRB-depletion results cellular reprogramming, quantitatively measured RB-depletion altered transcriptional, proteomic and metabolic output non-tumorigenic RPE1 These profiles identified widespread cell stress response factors previously linked to E2F function. In addition, find a number additional pathways are sensitive not E2F-regulated may represent...