A5009165743- Genetic Neurodegenerative Diseases
- RNA and protein synthesis mechanisms
- Genetics and Neurodevelopmental Disorders
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Advanced biosensing and bioanalysis techniques
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Rabies epidemiology and control
- Bacterial Genetics and Biotechnology
- Blood donation and transfusion practices
- Tuberculosis Research and Epidemiology
- Venomous Animal Envenomation and Studies
- Complement system in diseases
- Nanoparticle-Based Drug Delivery
- Cancer Mechanisms and Therapy
- Renal Diseases and Glomerulopathies
- COVID-19 and healthcare impacts
- Cholinesterase and Neurodegenerative Diseases
- Biosensors and Analytical Detection
- Insect and Pesticide Research
- Mechanisms of cancer metastasis
- Peripheral Artery Disease Management
- Nanocomposite Films for Food Packaging
- Inhalation and Respiratory Drug Delivery
The Ohio State University
2021-2025
Allegheny General Hospital
2024
Indian Institute of Technology Indore
2017-2023
Background: Medullary thyroid cancer (MTC) is a frequently metastatic tumor of the that develops from malignant transformation C-cells. These tumors most commonly have activating mutations within RET or RAS proto-oncogenes. Germline result in C-cell hyperplasia, and cause MTC pre-disposition disorder, multiple endocrine neoplasia, type 2A (MEN2A). Single-agent therapies for MTC, including vandetanib (VAN) cabozantinib all MTCs selpercatinib (SEL) RET-mutated lead to partial responses but are...
Huntington's disease (HD) is a neurodegenerative disorder that caused by abnormal expansion of CAG repeats in the HTT gene. The transcribed mutant RNA contains expanded translate into huntingtin protein. This repeat also causes mis-splicing pre-mRNA due to sequestration muscle blind like-1 splicing factor (MBNL1), and thus both these elicit pathogenesis HD. Targeting onset as well progression HD small molecules could be potent therapeutic approach. We have screened set target this transcript...
Abstract In majority of snakebite cases, the snake responsible for bite remains unidentified. The traditional diagnostics method relies upon clinical symptoms and blood coagulation assays that do not provide accurate diagnosis which is important epidemiological as well point view. On other hand, high batch-to-batch variations in antibody performance limit its application diagnostic assays. recent years, nucleic acid aptamers have emerged a strong chemical rival antibodies due to several...
Abstract CAG repeats RNA causes various fatal neurodegenerative diseases exemplified by Huntington’s disease (HD) and several spinocerebellar ataxias (SCAs). Although there are differences in the pathogenic mechanisms, these share common cause, i.e., expansion of repeats. The shared cause raises possibility for exploiting target as a potential therapeutic approach. Oligonucleotide-based therapeutics designed earlier with help base pairing rule but not very promiscuous, considering...
Factors like oxidative stress, environmental risk factors, genetics, chemical treatments, and resistance to treatment strategies all have serious impediments in scientific progress for treating diseases. Naturally occurring bioactive compounds when associated with nanocarriers could provide a solution tackling problems as therapeutic agents against cancer. This report investigates facile method of using ultrasonic atomization synthesizing piperine-loaded poly(d,l-lactide-co-glycolic acid)...
An expansion of CGG tandem repeats in the 5′ untranslated region (5′-UTR) fragile X mental retardation 1 (FMR1) gene causes X-associated tremor/ataxia syndrome (FXTAS). The transcripts these expanded r(CGG)exp either form RNA foci or undergo repeat-associated non-ATG (RAN) translation that produces toxic homopolymeric proteins neuronal cells. discovery small molecule modulators possess a strong binding affinity and high selectivity to could be promising therapeutic approach cure neurological...
Fragile X-associated tremor ataxia syndrome is an untreatable neurological and neuromuscular disorder caused by unstable expansion of 55-200 CGG nucleotide repeats in 5' UTR X intellectual disability 1 (FMR1) gene. The the FMR1 mRNA elicits neuronal cell toxicity through two main pathogenic mechanisms. First, with expanded sequester specific RNA regulatory proteins resulting splicing alterations formation ribonuclear inclusions. Second, repeat-associated non-canonical translation (RANT)...
DICER1 syndrome is a cancer pre-disposition disorder caused by mutations that disrupt the function of in miRNA processing. Studying molecular, cellular and oncogenic effects these can reveal novel mechanisms control cell homeostasis tumor biology. Here, we conduct first analysis pathogenic allele from 3'UTR. We find allele, rs1252940486, abolishes interaction with PUMILIO RNA binding protein 3'UTR, resulting degradation mRNA AUF1. This single mutational event leads to diminished levels,...
Gallbladder cancer (GBC) is an aggressive and difficult to treat biliary tract carcinoma with a poor survival rate. The aim of this study was design peptide-based multi-epitope vaccine construct against GBC using immunoinformatics approaches. Three proteins implicated in the progression were selected for B T cell epitope prediction designing potential construct. Seven CTL, four HTL six Bcell epitopes along suitable adjuvant connected linkers secondary tertiary models designed generated...
Prokaryotes encode a large number of GntR family transcription factors that are involved in various fundamental biological processes, including stress adaptation and pathogenesis. Here, we investigated the structural functional role Rv0792c, HutC homolog from M. tuberculosis .