A5063150864- vaccines and immunoinformatics approaches
- Computational Drug Discovery Methods
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- Congenital Heart Disease Studies
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Andrographolide Research and Applications
- Monoclonal and Polyclonal Antibodies Research
- Research on Leishmaniasis Studies
- Peptidase Inhibition and Analysis
- Cardiac Structural Anomalies and Repair
- Hepatitis B Virus Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Poxvirus research and outbreaks
- Bacteriophages and microbial interactions
- Diverse Scientific Research Studies
- Glycosylation and Glycoproteins Research
- Congenital Diaphragmatic Hernia Studies
- Tuberculosis Research and Epidemiology
- Phytochemical compounds biological activities
- Coronary Artery Anomalies
- Transgenic Plants and Applications
- Biliary and Gastrointestinal Fistulas
- Malaria Research and Control
Cincinnati Children's Hospital Medical Center
2025
Shiv Nadar University
2019-2024
Gajara Raja Medical College
2013-2023
Children's Hospital of Michigan
2021-2022
Shri Vishwakarma Skill University
2022
Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir
2022
Bridge University
2022
Mahavir Cancer Institute and Research Centre
2022
Detroit Medical Center
2021
The University of Texas Health Science Center at Houston
2020
Monkeypox virus (MPXV) outbreak in non-endemic countries is a worldwide public health emergency. An enveloped double-stranded DNA belongs to the genus Orth poxvirus. A viral zoonotic infection known as monkeypox has been serious risk health, especially Africa. However, it recently spread other continents, so might soon become problem. There an increased of transmission because there lack effective treatment that cures disease. To stop multi-country from spreading, important discover...
Background: Cardiogenic shock (CS) is one of the leading causes death in patients with myocardial infarction, myocarditis, and congestive heart failure. The utilization patterns specialist palliative care (PC) consultation these are currently unknown. Objectives: To determine PC CS overall comorbidities that population. Methods: Review 2020 National Inpatient Sample identified 6,471,165 hospitalizations which 38,531 were hospitalized via International Classification Diseases, Tenth Revision,...
Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. The presentation and treatment approach depends on severity right ventricular outflow tract obstruction, cases require a surgical correction. We describe neonate with pink TOF who exhibited typical echocardiographic characteristics such as aortic overriding, large VSD minimal or no pulmonary obstruction. patient lost to follow-up, repeat 5-year echocardiogram revealed absence overriding significantly restricted...
Background: Vein of Galen Aneurysmal Malformation (VGAM) is a rare vascular malformation that commonly diagnosed prenatally. Given the requirement complex neurosurgical interventions and poor morbidity associated with most cases, adequate preparation key. Non-specific manifestations as initial presentation can cause delay in making diagnosis. Case Presentation: We present case choroidal type VGAM after birth neonate who rapidly progressed to cardiovascular decompensation despite timely...
A recent surge in finding new candidate vaccines and potential antivirals to tackle atypical pneumonia triggered by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) needs unexplored approaches solving this global pandemic. The homotrimeric transmembrane spike (S) glycoprotein of coronaviruses which facilitates virus entry into host cells is covered with N-linked glycans having oligomannose complex sugars. These provide a unique opportunity for their targeting via...
Tropical Calcific Pancreatitis (TCP) is a chronic non-alcoholic pancreatitis characterised by extensive calcification. The disease usually appears at younger age and more common in tropical regions. This disease’s progression can lead to pancreatic diabetes, which subsequently cancer. CASR gene encodes calcium-sensing receptor (CaSR), GPCR protein of class C. It expressed the islets Langerhans, parathyroid gland, other tissues. primarily detects small gradients circulating calcium...
Globally, 2.3 million women were diagnosed with breast cancer, 6,85000 mortalities in year 2021; making it the world's most prevalent cancer. This growing global burden necessitates a new treatment option, and plant-based medicines offers promising alternative to conventional cancer treatment. In this work, screening of phytoconstituents an indigenous therapeutic plant, Bauhinia variegata carried out for potential regulator tumor suppressor protein p53. Here, in-silico analysis was employed...
Abstract We evaluated the anti-leishmanial efficacy of different saturated medium-chain fatty acids (FAs, C8–C18) where FA containing C8 chain, caprylic acid (CA), was found to be most potent against Leishmania donovani, causative agent for visceral leishmaniasis (VL). Different analogs CA with linear but not higher, along a carboxyl/ester group showed similar effect. Ergosterol depletion major cause CA-mediated cell death. Molecular docking and molecular dynamic simulation studies indicated...
A cell surface bile acid receptor TGR5 being considered as a novel target for Type II diabetes found to be expressed in various tissues. major role is maintain blood sugar levels and increase energy expenditure. These benefits make it potential candidate the treatment of type 2 diabetes, obesity other metabolic disorder. To date, many agonists have been synthesized evaluated literature, but very few silico computational studies reported. The discovery high-resolution crystal structure 2020...
Tropical calcific pancreatitis (TCP) is a juvenile form of non-alcoholic chronic seen exclusively in tropical countries. The disease poses high risk complications, including pancreatic diabetes and cancer, leading to significant mortality due poor diagnosis ineffective treatments. This study employed whole exome sequencing (WES) 5 TCP patient samples identify genetic variants associated with TCP. Advanced computational techniques were used gain atomic-level insights into progression,...
The nosocomial infection outbreak caused by
Complications such as bowel erosions, enterocutaneous fistulae are rare with the use of expandedpoly-tetrafluoroethylene (ePTFE) mesh in laparoscopic incisional hernia repair (LIHR). This unusual case patient presented to us necrotising fasciitis overlying anterior abdominal wall peritonitis withsepticaemia and underwent aLIHR6 weeks before, which has not been reported till yet. We report a LIHR, wall, septicaemia was managed by small segmental resection exteriorisation ends, debridement...
Background: Occupational lung diseases occurs in the workers exposed to occupation related hazards. These include Asthma, COPD, Coal worker pneumoconiosis, Silicosis and Asbestosis. Marble cutting exposes fine dust that can cause a number of pulmonary diseases. Usually these are people from rural areas they unaware health hazards occupation. Spreading awareness is key amongst people. The objective To study prevalence symptoms occupational marble workers, estimate current status preventive...
Gallbladder cancer (GBC) is an aggressive and difficult to treat biliary tract carcinoma with a poor survival rate. The aim of this study was design peptide-based multi-epitope vaccine construct against GBC using immunoinformatics approaches. Three proteins implicated in the progression were selected for B T cell epitope prediction designing potential construct. Seven CTL, four HTL six Bcell epitopes along suitable adjuvant connected linkers secondary tertiary models designed generated...
Tropical Calcific Pancreatitis (TCP) is a neglected juvenile form of chronic non-alcoholic pancreatitis. Cathepsin B (CTSB), lysosomal protease involved in the cellular degradation process, has recently been studied as potential candidate gene pathogenesis TCP. According to hypothesis, mutated CTSB can lead premature intracellular activation trypsinogen, key regulatory mechanism So far, mutations have pancreatitis and neurodegenerative disorders, but little known about structural functional...
The Peutz Jeghers syndrome (PJS) is an autosomal dominant disorder which characterised by hamartomatous polyposes of the gastrointestinal tract, melanin pigmentation skin and mucous membranes, increased risk for cancer. We are reporting a case 15-year-old male with syndrome, who presented to us features chronic intestinal obstruction anaemia. Initially, patient was managed conservatively, but later on, elective exploratory laparotomy done definitive management intussusception. Laparotomy...