A5101530240- Heat shock proteins research
- Research on Leishmaniasis Studies
- Protein Structure and Dynamics
- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
- Protein Degradation and Inhibitors
- Trypanosoma species research and implications
- Toxin Mechanisms and Immunotoxins
- Biocrusts and Microbial Ecology
- Dental Implant Techniques and Outcomes
- Photosynthetic Processes and Mechanisms
- Biochemical and Molecular Research
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Dental Radiography and Imaging
- Tuberculosis Research and Epidemiology
- Probiotics and Fermented Foods
- AI and HR Technologies
- Biological Research and Disease Studies
- Gastroesophageal reflux and treatments
- Advanced Proteomics Techniques and Applications
- Open Source Software Innovations
- Protist diversity and phylogeny
- Antimicrobial Peptides and Activities
- Ethics and Social Impacts of AI
Institute of Microbial Technology
2018-2025
Council of Scientific and Industrial Research
2018-2025
Broad Institute
2023-2025
Panjab University
2021-2025
Indian School of Business
2024
Banaras Hindu University
2018-2023
Creative Commons
2021
University of Delhi
2013
Ultraviolet radiation (UVR) has been scientifically proven to cause skin disorders such as sunburn, cancer and the symptoms of chronic exposure. Natural sun screening compounds have recently gained tremendous attention from cosmetic cosmeceutical sectors for treating hyperpigmentation aging. A wide range natural UV-absorbing used replace or reduce number synthetic sunscreen molecules. One primary causes photoaging is DNA damage, mainly caused by UVR. Photoprotection provided traditional...
Dentists across the globe are witnessing a completely unforeseen and uncertain professional situation during these times of COVID-19 pandemic. There is conflicting evidence regarding effectiveness routinely used mouthwashes especially Chlorhexidine, to reduce viral load in oral cavity aerosols procedures.Comparative evaluation current 'gold standard' chlorhexidine povidone iodine as control agent, through an in-vitro analysis.In-vitro laboratory analysis.All experiments for analysis...
Chimeric small molecules that induce post-translational modification (PTM) on a target protein by bringing it into proximity to PTM-inducing enzyme are furnishing novel modalities perturb function. Despite recent advances, such unavailable for critical PTM, tyrosine phosphorylation. Furthermore, the contemporary design paradigm of chimeric molecules, formed joining noninhibitory binder with protein, prohibits recruitment most enzymes as their binders unavailable. Here, we report two...
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. The presence of Lewy bodies, primarily consisting amyloid aggregates protein α-synuclein (α-Syn), a common feature seen in dopaminergic neurons patients. In present study, we screened 2320 FDA-approved drugs and found 3 lead molecules, sulfamerazine, lathosterol, tamoxifen, that reproducibly inhibited α-Syn fibrillation. Dose-response studies showed sulfamerazine lathosterol are relatively more potent than...
The TOX protein (thymocyte selection-associated high mobility group box) is a critical transcription factor implicated in both T acute lymphoblastic leukemia (T-ALL) and CD8+ cell exhaustion. Gene perturbation studies suggest that inhibiting may have therapeutic implications for However, due to its complex molecular mechanisms intrinsically disordered structure, has not been effectively targeted by small molecules date. In this study, we used molecule microarray (SMM) screening biochemical...
Background: Transtibial prosthetic sockets are critical components in the complete assembly of a prosthetic, as they form major load-bearing parts by housing residual limb prosthesis user. Conventional procedures for manufacturing these require repeated iterations and manual casting, baking, drying, which often lead to longer processing waiting times. Additive Manufacturing (AM) enables creation bespoke designs with meticulous control over socket’s shape, thickness, material composition....
This study was aimed to determine antimicrobial and antiviral activity of a novel lanthipeptide from Brevibacillus sp. for disinfectant application.The peptide (AMP) produced by bacterial strain AF8 identified as member the genus representing species. Whole genome sequence analysis using BAGEL putative complete biosynthetic gene cluster involved in synthesis. The deduced amino acid named brevicillin, showed >30% similarity with epidermin. Mass determined MALDI-MS Q-TOF suggested...
ABSTRACT In this study we utilized the concept of rational drug design to identify novel compounds with optimal selectivity, efficacy and safety, which would bind target enzyme pteridine reductase 1 (PTR1) in Leishmania parasites. Twelve afforded from Baylis-Hillman chemistry were docked by using QUANTUM program into active site donovani PTR1 homology model. The biological activity for these was estimated green fluorescent protein-transfected L. promastigotes, most potential analogue further...
The mechanism underlying the role of Hsp70s in toxicity associated with intracellular accumulation toxic protein inclusions is under intense investigation. In current study, we examined roles all different isoforms yeast cytosolic Ssa Hsp70 on α-synuclein mediated cellular toxicity. study showed that cells expressing stress-inducible Ssa3 or Ssa4 as sole isoforms, reduced better than those a constitutive counterpart. protective effect was not α-syn specific, but more general to other...
Abstract Heat-shock protein (Hsp) 90 assists in the folding of diverse sets client proteins including kinases and growth hormone receptors. Hsp70 plays a major role many Hsp90 functions by interacting modulating conformation its substrates before being transferred to Hsp90s for final maturation. Each eukaryote contains multiple members family. However, different isoforms chaperoning actions remains unknown. Using v-Src as an substrate, we examined each four yeast cytosolic Ssa Hsp70s...
Prokaryotes encode a large number of GntR family transcription factors that are involved in various fundamental biological processes, including stress adaptation and pathogenesis. Here, we investigated the structural functional role Rv0792c, HutC homolog from M. tuberculosis .
Introduction: Chlorhexidine gluconate mouthwash has earned eponym of gold standard to treat and/or prevent periodontal disease. The present study was carried out with an aim evaluate the efficacy CHX as a supplement regular toothbrushing. Materials and Methods: in 40 patients mouth rinses i.e (Vyrex Mouthwash (0.2% w/v), tooth brushing on plaque accumulation gingival inflammation chronic generalized gingivitis inflammation, taste alteration & score were at 14, 21 28 day. Results: No...
Enterprises grapple with the significant challenge of managing proprietary unstructured data, hindering efficient information retrieval. This has led to emergence AI-driven retrieval solutions, designed adeptly extract relevant insights address employee inquiries. These solutions often leverage pre-trained embedding models and generative as foundational components. While embeddings may exhibit proximity or disparity based on their original training objectives, they might not fully align...