A5030837429- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Biochemical Acid Research Studies
- ATP Synthase and ATPases Research
- Phytochemicals and Medicinal Plants
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Medicinal Plants and Neuroprotection
- Medicinal Plants and Bioactive Compounds
- COVID-19 and healthcare impacts
- Oral health in cancer treatment
- Migration, Health and Trauma
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Bioactivity Studies
- Systemic Sclerosis and Related Diseases
- Muscle Physiology and Disorders
- Oral microbiology and periodontitis research
- Dermatological and Skeletal Disorders
- Bioactive Natural Diterpenoids Research
- Adipose Tissue and Metabolism
- Saffron Plant Research Studies
- Telemedicine and Telehealth Implementation
- Photosynthetic Processes and Mechanisms
- Salivary Gland Disorders and Functions
Institute of Microbial Technology
2022-2025
Council of Scientific and Industrial Research
2022-2025
Chitkara University
2024
Panjab University
2010-2024
University of Padua
2016-2017
The mitochondrial contact site and cristae organizing system (MICOS) Optic atrophy 1 (OPA1) control shape, thus affecting function apoptosis. Whether how they physically functionally interact is unclear. Here, we provide evidence that OPA1 epistatic to MICOS in the regulation of shape. Proteomic analysis identifies multiple components native OPA1-containing high molecular weight complexes disrupted during remodeling. MIC60, a core protein, interacts with OPA1, together, junction number...
Mitochondrial dysfunction is a major event involved in the pathogenesis of Huntington’s disease (HD). The present study evaluates role <i>N</i>-acetyl-<i>L</i>-cysteine (NAC) preventing mitochondrial dysfunctions 3-nitropropionic acid (3-NP)-induced model HD. Administration 3-NP to rats (Wistar strain) resulted significant inhibition complexes II, IV and V striatum. However, no effect on complex I was observed. Increased generation reactive oxygen species lipid...
In recent times, there have been notable advancements in comprehending the potential anti-cancer effects of chrysin (CH), a naturally occurring flavonoid compound found abundantly various plant sources like honey, propolis, and certain fruits vegetables. This active has garnered significant attention due to its promising therapeutic qualities minimal toxicity. CH’s ability combat cancer arises from multifaceted mechanisms action, including initiation apoptosis inhibition proliferation,...
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. The presence of Lewy bodies, primarily consisting amyloid aggregates protein α-synuclein (α-Syn), a common feature seen in dopaminergic neurons patients. In present study, we screened 2320 FDA-approved drugs and found 3 lead molecules, sulfamerazine, lathosterol, tamoxifen, that reproducibly inhibited α-Syn fibrillation. Dose-response studies showed sulfamerazine lathosterol are relatively more potent than...
The essential roles and responsibilities of healthcare professionals commissioned on the frontlines active war zone/s are indispensible, wherein they explicitly exposed to detrimental conditions due conflicting situations. With compromised infrastructure in zones, role workers becomes fundamental delivering urgent medical care while facing significant risks. Beyond instantaneous availability medication, manoeuvre through psychological trauma war, addressing prevalent ordeal inadequate mental...
Mitochondrial dysfunctions have been implicated in the progression of Huntington's disease (HD). To date, several free radical scavengers tested experimental HD, but only a few shown promise. Although most antioxidants rapidly reduce ROS process they are oxidized, which limits their ability to protect. Therefore, present study we employed potent recycling antioxidant, 4-hydroxy tempo (4-HT), because it can reinstate its reduced state even after oxidation during scavenging ROS. Female Wistar...
Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disease. The presence of lewy bodies, primarily consisting α-synuclein (α-syn) aggregates one features seen in substantia nigra region brain PD patients. remains incurable and only symptomatic relief available. We screened various cell-penetrating peptides reveal that penetratin a potent inhibitor α-syn aggregation in-vitro , significantly improved locomotor coordination mice models in-vivo . peptide inhibits vitro...
Background/Aim: Mitochondria are one of the most dynamic organelles essential for maintaining cellular energy demands, including execution several vital processes. This feature is attributed to rapid adaptation in morphological features which dictates their functionality. Depending on status, mitochondria can be rod shaped, branched, spherical , interconnected or exist as a network. Aim this study was analyse mitochondrial appearance under normal vs stress condition mitochondria. Methods:...