A5076777692- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- CAR-T cell therapy research
- Iron Metabolism and Disorders
- Pancreatic and Hepatic Oncology Research
- Cardiovascular Function and Risk Factors
- Epigenetics and DNA Methylation
- Soft tissue tumors and treatment
- Cardiovascular Health and Disease Prevention
- Colorectal Cancer Treatments and Studies
- Celiac Disease Research and Management
- Palliative Care and End-of-Life Issues
- RNA regulation and disease
- Cancer survivorship and care
- Chronic Lymphocytic Leukemia Research
- Blood donation and transfusion practices
- Neutropenia and Cancer Infections
- Nutrition and Health in Aging
- Colorectal and Anal Carcinomas
- Complement system in diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Urinary and Genital Oncology Studies
- COVID-19 and healthcare impacts
- Ureteral procedures and complications
Allegheny General Hospital
2024
Allegheny Health Network
2021-2023
University of Michigan
2014-2021
Tel Aviv University
2015-2018
Rabin Medical Center
2018
Ann Arbor Center for Independent Living
2015-2017
Michigan Medicine
2016
Brigham and Women's Hospital
2014-2015
Sheba Medical Center
2015
Harvard University Press
2011
To determine the relationship between long-term prostate cancer survivors' symptom burden and information needs.We used population-based data from Michigan Prostate Cancer Survivor Study (2499 men). We examined unadjusted differences in needs according to performed multivariable logistic regression examine adjusting for patient characteristics.High was reported across all domains (sexual 44.4%, urinary 14.4%, vitality 12.7%, bowel 8.4%, emotional 7.6%) with over half of respondents (56%)...
Hospital readmissions after radical cystectomy vary with respect to intensity in terms of impact on patients and health care systems. Therefore, we conducted a population based study examine factors associated increasing readmission for bladder cancer.Using SEER (Surveillance, Epidemiology, End Results)-Medicare data identified 1,782 who underwent from 2003 2009. We defined length stay (days) divided into quartiles less than 3 (lowest), 4, 5 7 more (highest). used logistic regression...
Radical cystectomy has one of the highest readmission rates across all surgical procedures at approximately 25%. We developed a mathematical model to optimize outpatient followup regimens for radical cystectomy.We used delay-time analysis, systems engineering approach, maximize probability detecting patients susceptible through office visits and telephone calls. Our data source includes readmitted after from Healthcare Cost Utilization Project State Inpatient Databases in 2009 2010 as well...
Immune checkpoint inhibitors (ICIs) in the recent times have transformed landscape of management many solid tumors. Unfortunately, immune-related adverse effects are associated with ICIs, which lead to a negative outcome cancer treatment. We present case 63-year-old female metastatic adenocarcinoma unknown origin, who developed celiac disease during course treatment pembrolizumab. Association this form immunotherapy has never been documented before.
293 Background: We conducted a phase II trial to evaluate combination therapy with intravesical BCG + sunitinib for prevention of recurrence and progression NMIBC. Methods: Patients high-grade clinical ≤ T1N0M0 NMIBC without in the past year were eligible received induction followed 2 weeks later by 28 days (50mg). The primary endpoint was 3 month complete response (CR) biopsy cytology. incomplete second cycle sunitinib. Secondary endpoints included 2-year progression-free survival (RFS,...
Background Soluble endoglin, a TGF-β receptor, plays key role in cardiovascular physiology. Whether circulating concentrations of soluble endoglin are elevated CKD or underlie the high risk death associated with chronic kidney disease (CKD) is unknown. Methods Individuals and without were recruited at single center. Estimated glomerular filtration rate (eGFR) was estimated using modified MDRD study equation serum creatinine time recruitment, patients assigned to specific stage according...
You have accessJournal of UrologyProstate Cancer: Detection & Screening II1 Apr 2017PD07-03 MICHIGAN PROSTATE SCORE (MIPS): AN ANALYSIS OF A NOVEL URINARY BIOMARKER PANEL FOR THE PREDICTION CANCER AND ITS IMPACT ON BIOPSY RATES Amir H. Lebastchi, Christopher M. Russell, Alexander Helfand, Takahiro Osawa, Javed Siddiqui, Rabia Arul Chinnaiyan, Priya Kunju, Rohit Mehra, Debbie Snyder, Scott A. Tomlins, Jont T. Wei, and Todd Morgan LebastchiAmir Lebastchi More articles by this author ,...
Segmental neurofibromatosis (SNF) is a rare type of (NF-1) resulting from post-zygotic somatic mutations in the neurofibromin gene that leads to mosaicism. Reported manifestations SNF include neurofibromas, freckling, or café-au-lait spots limited single body region limb. We present 5-month-old male referred our clinic for evaluation congenital excessive skin folds on back. A mildly erythematous, poorly demarcated soft plaque was noted, consisting folds. cluster light brown hyperpigmented...
You have accessJournal of UrologyBladder Oncology/Testis/Transplantation/Trauma1 Apr 2015V8-09 ROBOTIC-ASSISTED INGUINAL LYMPHADENECTOMY: EARLY OUTCOMES AND TECHNICAL MODIFICATIONS Alexander M. Helfand, Jeffrey S. Montgomery, Alon Z. Weizer, and Todd Morgan HelfandAlexander Helfand More articles by this author , MontgomeryJeffrey Montgomery WeizerAlon Weizer MorganTodd View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2133AboutPDF ToolsAdd to favoritesDownload CitationsTrack...
You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History III1 Apr 2015MP14-07 WHAT ARE WE MISSING? THE PERSISTENCE OF VITALITY SYMPTOM BURDEN IN LONG-TERM PROSTATE CANCER SURVIVORS WITHOUT RECURRENT DISEASE Alexander M. Helfand, Naveen Krishnan, Daniela A. Wittmann, Sarah T. Hawley, Chang He, May Darwish-Yassine, and Ted Skolarus HelfandAlexander Helfand More articles by this author , KrishnanNaveen Krishnan WittmannDaniela Wittmann HawleySarah Hawley HeChang He...
This case report describes a man in his 60s with no cancer history who presented 2 weeks of dysphagia, dysphonia, and left neck mass.
e18683 Background: Cancer-directed therapy, including cytotoxic chemotherapy and immunotherapy, is a known risk factor for decreased SARS-CoV-2 seroconversion after vaccination, as result of impaired viral immunity. Outcomes COVID-19 infection are worse in patients on active treatment, especially those with hematologic malignancies or undergoing stem cell transplantation. The association between cancer subtypes rates not well established. goal this study was to investigate predictive factors...
e19021 Background: Blinatumomab, a bispecific (CD3/CD19) T-cell engager, is indicated for the treatment of acute lymphoblastic leukemia (ALL). The initial portion each cycle administered in inpatient setting close monitoring cytokine release syndrome and neurotoxicity. Real world data are lacking on cost hospitalization, length stay (LOS), mortality inpatients treated with blinatumomab. goal this study was to analyze clinical outcomes blinatumomab administration utilizing national database....
e19501 Background: Chimeric antigen receptor T-cell therapies (CAR-T) improve relapse free survival and durable remission rates in patients with relapsed/refractory large B-cell lymphoma (LBCL) received US FDA approval 2017. The cytokine release syndrome (CRS) immune-effector cell associated neurotoxicity (ICANS) due to CAR-T therapy require close inpatient monitoring. Real world data are lacking regarding the cost of hospitalization, length stay (LOS), toxicity, mortality CAR-T. goal this...
e21053 Background: Treatment with immune checkpoint inhibitors (CPI) targeting PD-1 or PD-L1 significantly improves progression free survival and overall in patients non-small cell lung cancer (NSCLC). Emerging literature suggests that the proinflammatory state of CPIs may increase risk thromboembolism, both venous (VTE) arterial (ATE), which is great concern as thromboembolism remains a major cause mortality NSCLC. We performed retrospective cohort study to evaluate thromboembolic outcomes...