A5093010583- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Multiple Sclerosis Research Studies
- 3D Printing in Biomedical Research
- Neurogenesis and neuroplasticity mechanisms
- Functional Brain Connectivity Studies
Tampere University
2023-2025
Background: Microglia and astrocytes have been implicated as central mediators of neuroinflammatory processes in several neurodegenerative diseases. However, their intricate crosstalk contributions to pathogenesis remain elusive, highlighting the need for innovative vitro approaches investigating glial interactions neuroinflammation. The aim this study was develop advanced human-based coculture models explore inflammatory roles microglia . Methods: We utilized human induced pluripotent stem...
Abstract Previous studies have shown that aggregated alpha-synuclein (α-s) protein, a key pathological marker of Parkinson’s disease (PD), can propagate between cells, thus participating in progression. This prion-like propagation has been widely studied using vivo and vitro models, including rodent human cell cultures. In this study, our focus was on temporal assessment functional changes during α-s aggregation induced pluripotent stem (hiPSC)-derived neuronal cultures engineered networks....
Abstract Aberrant and sustained activation of microglia is implicated in the progression severity multiple sclerosis (MS). However, whether intrinsic alterations microglial function impact pathogenesis this disease remains unclear. We conducted transcriptomic functional analyses microglia-like cells (iMGLs) differentiated from induced pluripotent stem (iPSCs) patients with MS (pwMS) to answer question. generated iPSCs six pwMS showing increased activity via translocator protein (TSPO)-PET...
<title>Abstract</title> Previously, several in vitro and vivo studies have shown that the pathological hallmark of Parkinson’s disease (PD), malicious strains alpha-synuclein (α-s) protein, are transferred between cells via different routes, thus participating progression. The amplification α-s propagation its aggregated forms described as prion-like widely supported by rodent human cell studies. In this study, our focus was on temporal assessment functional changes during aggregation...