A5070303965- 3D Printing in Biomedical Research
- Plasma Applications and Diagnostics
- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- Video Analysis and Summarization
- Speech and Audio Processing
- Music and Audio Processing
- Spaceflight effects on biology
- Photoreceptor and optogenetics research
- Pluripotent Stem Cells Research
- Electrohydrodynamics and Fluid Dynamics
- Cardiac Fibrosis and Remodeling
- Electrospun Nanofibers in Biomedical Applications
- Planarian Biology and Electrostimulation
- Micro and Nano Robotics
- Renal and related cancers
- Philosophical and Cultural Analysis
- Neuroscience and Neural Engineering
- Domain Adaptation and Few-Shot Learning
- Heme Oxygenase-1 and Carbon Monoxide
- Mercury impact and mitigation studies
- Congenital Heart Disease Studies
- Human Pose and Action Recognition
- Multimodal Machine Learning Applications
- Plasma Diagnostics and Applications
Artificial Intelligence in Medicine (Canada)
2023
Massachusetts Institute of Technology
2013-2022
Cardiovascular Institute of the South
2021-2022
Stanford University
2021-2022
Korea Advanced Institute of Science and Technology
2011-2014
When treated by atmospheric pressure plasma, human liver cancer cells (SK-HEP-1) and normal (THLE-2) exhibited distinctive cellular responses, especially in relation to their adhesion behavior. We discovered the critical threshold voltage of 950 V, biased at electrode micro-plasma jet source, above which SK-HEP-1 started detach from substrate while THLE-2 remained intact. Our mechanical biochemical analyses confirmed presence intrinsic differences properties between cells, provide a clue...
We demonstrate a novel technique to construct parallel assemblies of smaller muscle strips that maximize the volume active layers. In tandem with multiple strips, external control through use optogenetics can selectively recruit for gradation these forces.
Engineered skeletal muscles are inferior to natural in terms of contractile force, hampering their potential use practical applications. One major limitation is that the extracellular matrix (ECM) not only impedes contraction but also ineffectively transmits forces generated by myotubes load. In present study, ECM remodelling improves force a short time, and coordinated, combined electrical mechanical stimulation induces desired remodelling. Notably, application single stimulations...
Constructing engineered human skeletal muscle tissues that resemble the function and microstructure of muscles is key to utilizing them in a variety applications such as drug development, disease modeling, regenerative medicine, engineering biological machines. However, current vitro are far inferior native terms contractile lack essential cues for functions, particularly heterotypic cell-cell interactions between myoblasts, endothelial cells, fibroblasts. Here, we develop an tissue with...
Atmospheric pressure plasma (APP) has been recognized as a promising tool for cancer therapy based on its ability to remove cells by causing apoptosis and necrosis. However, the effect of APP neighboring tissues tumors remains unknown. Moreover, role vessels near could be very important, because once tumor becomes vascularized, potential metastasis can increase dramatically. We show in present study that induce cell cycle arrest endothelial further suppress angiogenesis process. These...
Abstract Creating a vasculature in engineered human skeletal muscle tissues (ehSMTs) enables us to create thick tissues, increase cell survival implantation, provide models of blood-organ barriers for drug testing, and enhance differentiation through paracrine signaling. Here, contractile ehSMTs with central perfusable vascular channel microvascular networks growing from this into the surrounding tissue were newly demonstrated. Because coculturing cells endothelial requires incompatible...
Generation of human cardiomyocytes (CMs), cardiac fibroblasts (CFs), and endothelial cells (ECs) from induced pluripotent stem (iPSCs) has provided a unique opportunity to study the complex interplay among different cardiovascular cell types that drives tissue development disease. In area models, several sophisticated three-dimensional (3D) approaches use cell-derived (iPSC-CMs) mimic physiological relevance native environment with combination extracellular matrices crosslinkers. However,...
Representing wild sounds as images is an important but challenging task due to the lack of paired datasets between sound and significant differences in characteristics these two modalities. Previous studies have focused on generating from limited categories or music. In this paper, we propose a novel approach generate in-the-wild sounds. First, convert into text using audio captioning. Second, attention sentence represent rich visualize sound. Lastly, direct optimization with CLIPscore...
Generation of human cardiomyocytes (CMs), cardiac fibroblasts (CFs), and endothelial cells (ECs) from induced pluripotent stem (iPSCs) has provided a unique opportunity to study the complex interplay among different cardiovascular cell types that drives tissue development disease. In area models, several sophisticated three-dimensional (3D) approaches use cell-derived (iPSC-CMs) mimic physiological relevance native environment with combination extracellular matrices crosslinkers. However,...
Summary form only given. Atmospheric pressure plasma (APP) has been studied over the years as an excellent biological and medical tool for its simplicity in application capability to induce various bio-chemical reactions. In this presentation, we show effect of APP on inactivation microorganisms (E. coli, Bacillus subtillis, Listeria monocytogenes, Salmonella Typhimurium) by showing several log reduction microbial population, mammalian cells especially focused how influences actual structure...
Engineered skeletal muscle tissue has the potential to be used as dual use actuator and stress-bearing material providing numerous degrees of freedom with significant active stress generation. To exploit features, however, technologies must established generate mature strips that can controlled high fidelity. Here, we present a method for creating 3-D tissues contract in response optical activation stimuli. The are fascicle-like, consisting several mm-long multi-nucleate cells bundled...
Representing wild sounds as images is an important but challenging task due to the lack of paired datasets between sound and significant differences in characteristics these two modalities. Previous studies have focused on generating from limited categories or music. In this paper, we propose a novel approach generate in-the-wild sounds. First, convert into text using audio captioning. Second, attention sentence represent rich visualize sound. Lastly, direct optimization with CLIPscore...
There has been a great deal of interests in application atmospheric pressure plasma (APP) for biomedical and clinical uses such as cancer therapy wound healing. However, most these studies have limited to adhesion apoptosis cells induced by APP epithelial cells. In this study, we investigated the effects moderate (970 V, 50 kHz, 20 min) on human aortic endothelial (HAECs). Some phenotypic changes were observed treated HAECs. Dramatic reduction cell population was which indicates cellular...
This technical report presents the 2nd winning model for AQTC, a task newly introduced in CVPR 2022 LOng-form VidEo Understanding (LOVEU) challenges. challenge faces difficulties with multi-step answers, multi-modal, and diverse changing button representations video. We address this problem by proposing new context ground module attention mechanism more effective feature mapping. In addition, we also perform analysis over number of buttons ablation study different step networks video...