A5100458093- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Atomic and Subatomic Physics Research
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Electrospun Nanofibers in Biomedical Applications
- Advanced NMR Techniques and Applications
- Medical Imaging Techniques and Applications
- Electron Spin Resonance Studies
- NMR spectroscopy and applications
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging and Analysis
- Speech Recognition and Synthesis
- Fetal and Pediatric Neurological Disorders
- Magnetism in coordination complexes
- Speech and Audio Processing
- Phonetics and Phonology Research
- Spine and Intervertebral Disc Pathology
- Plasma Applications and Diagnostics
- Advanced Radiotherapy Techniques
- Neural dynamics and brain function
- Muscle Physiology and Disorders
- Silicone and Siloxane Chemistry
- Fiber-reinforced polymer composites
University College London
2018-2024
Samsung Medical Center
2021-2024
Imaging Center
2024
Children's Hospital of Philadelphia
2024
University of Pennsylvania
2024
Samsung (South Korea)
2019-2022
Sungkyunkwan University
2021-2022
National Hospital for Neurology and Neurosurgery
2019-2022
Korea Advanced Institute of Science and Technology
2011-2021
University of Hong Kong
2010-2021
Abstract Chemical exchange saturation transfer (CEST) is a contrast mechanism that exploits exchange‐based magnetization (MT) between solute and water protons. CEST effects compete with direct conventional MT processes, generally can only be quantified through an asymmetry analysis of the spectrum ( Z ‐spectrum) respect to frequency, process exquisitely sensitive magnetic field inhomogeneities. Here it shown imaging allows measurement absolute frequency in each voxel, allowing proper...
Abstract Amide proton transfer (APT) imaging is a type of chemical exchange–dependent saturation (CEST) magnetic resonance (MRI) in which amide protons endogenous mobile proteins and peptides tissue are detected. Initial studies have shown promising results for distinguishing tumor from surrounding brain patients, but these data were hampered by field inhomogeneity low signal‐to‐noise ratio (SNR). Here practical six‐offset APT acquisition scheme presented that, together with separately...
We compare fMRI-BOLD responses in anesthetized cats with local field potentials (LFPs), aggregate high-frequency (analog-Mua) and spiking activity recorded primary higher visual cortex of alert animals. The similarity the activations these electrophysiological signals to those BOLD is quantified by counting recording sites where different stimuli elicit same relative activation as imaging experiments. Using artificial stimuli, a comparison LFP strongly depends on frequency range used....
When treated by atmospheric pressure plasma, human liver cancer cells (SK-HEP-1) and normal (THLE-2) exhibited distinctive cellular responses, especially in relation to their adhesion behavior. We discovered the critical threshold voltage of 950 V, biased at electrode micro-plasma jet source, above which SK-HEP-1 started detach from substrate while THLE-2 remained intact. Our mechanical biochemical analyses confirmed presence intrinsic differences properties between cells, provide a clue...
Abstract Recent studies have proposed that glycosaminoglycan chemical exchange saturation transfer (gagCEST) is associated with a loss of glycosaminoglycans (GAGs), which may be an initiating factor in intervertebral disc (IVD) degeneration. Despite its promising potential, this application has not been reported human vivo IVD because the challenges B 0 magnetic field inhomogeneity gagCEST. This study aimed to evaluate feasibility quantifying CEST values IVDs healthy volunteers using...
Dynamic CEST studies such as dynamic glucose enhanced imaging, have gained a lot of attention recently. The expected effects after injection are rather small in tissue especially at clinical field strengths (0.5-2%). Small movements during the measurement together with subtraction-based evaluation can lead to pseudo same order magnitude. These artifacts studied herein.A brain tumor patient 3D-CEST baseline scan without performed 3 T is used generate virtual introducing different kinds...
Abstract Purpose: To investigate whether quantitative MRI measures of cervical spinal cord white matter (WM) using diffusion tensor imaging (DTI) in neuromyelitis optica (NMO) differed from controls and correlated with clinical disability. Materials Methods: Ten referred patients 12 healthy volunteers were imaged on a 3 Tesla scanner clinically assessed the Expanded Disability Status Scale (EDSS). Two raters quantified DTI‐derived indices all participants, including fractional anisotropy...
The purpose of this study was to report the feasibility ultrashort time-to-echo (UTE) MRI technique assess cartilaginous endplate (CEP) defects in humans vivo and their relationship with intervertebral disc (IVD) degeneration.Nine volunteer subjects (mean age = 43.9 years; range 22-61 years) were recruited, representing 54 IVDs 108 CEPs. underwent T2-weighted UTE for presence severity IVD degeneration, CEP defects, respectively, from T12 S1. degeneration graded according Schneiderman et al....
Hypoxia is a feature of most solid tumors and key determinant cancer growth propagation. Sensing hypoxia effectively could lead to more favorable clinical outcomes. Here, we report molecular antenna-based bimodal probe designed exploit the complementary advantages magnetic resonance (MR)- optical-based imaging. Specifically, describe synthesis evaluation dual-action (NO2-Eu) that permits hypoxia-activated chemical exchange saturation transfer (CEST) MR optical In CT26 cells, this NO2-Eu not...
In this paper, we propose and implement an efficient robot name registration recognition system in order to provide a call-and-come service for home robots. The is designed enable come user when its called correctly by the user. Therefore, techniques such as voice detection, robust speech detection of location use are required. For voice, proposed method first restricts search space using monophone-based acoustic models. Then, names completed triphone-based models restricted space. reliable...
In order to achieve continuous biocatalytic hydration of CO(2), carbonic anhydrase (CA) derived from Rhodobacter sphaeroides was immobilized on electrospun polystyrene/poly(styrene-co-maleic anhydride) (PS/PSMA) nanofibers as cross-linked enzyme aggregates (CLEA). The CA-CLEA maintained more than 94.7% its initial activity during 60 days storage period at 4 °C and also retained 45.0% after reuses. capability hydrolyze CO(2) verified in terms CaCO(3) precipitation. CA induced enhanced cell...
Background: The aim of this study was to translate dynamic glucose enhancement (DGE) body magnetic resonance imaging (MRI) based on the chemical exchange saturation transfer (glucoCEST) signal a 3 T clinical field strength. Methods: An infusion protocol for intravenous (i.v.) optimised using hyperglycaemic clamp maximise chances detecting exchange-sensitive MRI signal. Numerical simulations were performed define optimum parameters glucoCEST measurements with consideration physiological...
We developed an immuno-PET technique that monitors modulation of tumor CD133 expression, which is required for the success CD133-targeted therapies. Methods. Anti-CD133 antibodies were subjected to sulfhydryl moiety-specific 89 Zr conjugation. Zr-CD133 IgG was evaluated specific activity and radiolabel stability. Colon cancer cells underwent binding assays Western blotting. Biodistribution PET studies performed in mice. Results. showed excellent target specificity with [Formula: see text]...
A major challenge in muscle tissue engineering is mimicking the ordered nanostructure of native collagen fibrils muscles. Electrospun nanofiber constructs have been proposed as promising candidate alternatives to natural extracellular matrix. Here, we introduce a novel method fabricate two-dimension (2D) sheet-type and three-dimensionally integrated nanofibrous scaffolds by combining electrospinning rapid prototyping. The aligned 2D mats can be processed into different configurations...
Atmospheric pressure plasma (APP) has been recognized as a promising tool for cancer therapy based on its ability to remove cells by causing apoptosis and necrosis. However, the effect of APP neighboring tissues tumors remains unknown. Moreover, role vessels near could be very important, because once tumor becomes vascularized, potential metastasis can increase dramatically. We show in present study that induce cell cycle arrest endothelial further suppress angiogenesis process. These...