A5071787968- IoT and Edge/Fog Computing
- Immune Cell Function and Interaction
- Network Security and Intrusion Detection
- Big Data and Business Intelligence
- Histone Deacetylase Inhibitors Research
- Artificial Intelligence in Healthcare
- Blockchain Technology Applications and Security
- Advanced Malware Detection Techniques
- Stock Market Forecasting Methods
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Anomaly Detection Techniques and Applications
- Context-Aware Activity Recognition Systems
- Adenosine and Purinergic Signaling
- Advanced Neural Network Applications
- Spam and Phishing Detection
- Cholesterol and Lipid Metabolism
- Internet of Things and AI
- Data Mining Algorithms and Applications
- Sentiment Analysis and Opinion Mining
- Forecasting Techniques and Applications
- Market Dynamics and Volatility
- Smart Agriculture and AI
- Machine Learning in Healthcare
- Distributed and Parallel Computing Systems
Barkatullah University
2020-2025
Madhya Pradesh Bhoj Open University
2021-2024
Jagran Lakecity University
2023-2024
Vellore Institute of Technology University
2020-2024
Biju Patnaik University of Technology
2024
National Institute of Technology Rourkela
2022
Indira Gandhi Institute of Technology
2022
Debre Berhan University
2017-2019
Fakir Mohan University
2018
Chang Gung University
2014-2017
Studies in human systemic lupus erythematosus (SLE) suggest a possible role for histone deacetylases (HDACs) skewed gene expression and disease pathogenesis. We used the MRL-lpr/lpr murine model of to demonstrate that HDACs play key heightened levels both Th1 Th2 cytokine contribute disease. The availability specific HDAC inhibitors (HDIs) such as trichostatin A (TSA) suberonylanilide hydroxamic acid (SAHA) permits study regulation. Our results indicate HDIs downregulate IL-12, IFN-gamma,...
Macrophage-specific Abca1 knock-out (Abca1(-)(M)(/-)(M)) mice were generated to determine the role of macrophage ABCA1 expression in plasma lipoprotein concentrations and innate immune response macrophages. Plasma lipid chow-fed Abca1(-)(M)(/-)(M) wild-type (WT) indistinguishable. Compared with WT macrophages, macrophages had a >95% reduction protein, failed efflux apoA-I, significant increase free cholesterol (FC) membrane rafts without induction endoplasmic reticulum stress....
Post-translational modifications (PTMs) of histones play an important role in many cellular processes, notably gene regulation. Using a combination mass spectrometric and immunobiochemical approaches, we show that the PTM profile histone H3 differs significantly among various model organisms examined. Unicellular eukaryotes, such as Saccharomyces cerevisiae (yeast) Tetrahymena thermophila (Tet), for example, contain more activation than silencing marks compared with mammalian cells (mouse...
Abstract Introduction This trial evaluated the safety, biologic activity, and pharmacokinetics of belimumab, a fully human monoclonal antibody that inhibits activity soluble form essential B-cell survival factor B-lymphocyte stimulator (BLyS) in patients with systemic lupus erythematosus (SLE). Methods Seventy mild-to-moderate SLE were enrolled phase I, double-blind, randomized study treated placebo ( n = 13) or belimumab 57) at four different doses (1.0, 4.0, 10, 20 mg/kg) as single...
Objective— Recent genome-wide association studies revealed that a genetic variant in the loci corresponding to histone deacetylase 9 (HDAC9) is associated with large vessel stroke. HDAC9 expression was upregulated human atherosclerotic plaques different arteries. The molecular mechanisms how might increase atherosclerosis not clear. Approach and Results— In this study, we show systemic bone marrow cell deletion of decreased LDLr −/− (low density lipoprotein receptor) mice minimal effect on...
Green finance can be referred to as financial investments made on sustainable projects and policies that focus a economy. The procedures include promoting renewable energy sources, efficiency, water sanitation, industrial pollution control, transportation reduction of deforestation, carbon emissions, etc. Mainly, these green initiatives are carried out by private public agents like business organizations, banks, international government provides solution create positive impact society leads...
Proactive healthcare management has made personal health tracking and analysis commonplace. Raspberry Pi-enabled wearable sensors assess in this study. Wearable with the inexpensive Pi give a flexible platform for real-time physiological environmental data collection analysis. Pi's computing, connectivity, expandability enable tracking. The readily integrates like heart rate monitor, accelerometer, temperature sensor, GPS module to detect physical activity, variables, vital signs. Machine...
This research study proposes a novel system that integrates Wireless Sensor Networks (WSNs) with cloud-based platforms to efficiently generate renewable energy and produce clean fuel. By enhancing the safety, efficiency, reliability of solar power hydrogen generation, optimization strategies, data analysis, real-time monitoring. Critical parameters such as temperature, sun irradiance, electrolysis purity are monitored using WSNs, transmitted processed via cloud techniques identify patterns,...
In systemic lupus erythematosus (SLE), T helper cells exhibit increased and prolonged expression of cell-surface CD40 ligand (CD154), spontaneously overproduce interleukin-10 (IL-10), but underproduce interferon-gamma (IFN-γ). We tested the hypothesis that imbalance these gene products reflects skewed CD154 , IL-10 IFN- γ genes. Here, we demonstrate histone deacetylase inhibitor, trichostatin A, significantly down-regulated up-regulated in SLE cells. This reversal corrected aberrant...
Abstract Epigenetic regulation of gene expression is involved in the development many diseases. Histone acetylation a posttranslational modification nucleosomal histone tails that regulated by balance deacetylases and acetyltransferases. Alterations have been shown to cause aberrant genes are hallmark diseases, including systemic lupus erythematosus. In this study, we determined whether suberoylanilide hydroxamic acid (SAHA), deacetylase inhibitor: 1) inhibits inflammatory mediator...
The baseline level of gene expression varies between healthy controls and systemic lupus erythematosus (SLE) patients, among SLE patients themselves. These variations may explain the different clinical manifestations severity disease observed in SLE. Epigenetic mechanisms, which involve DNA histone modifications, are predictably associated with distinct transcriptional states. To understand interplay various including acetylation methylation, disease, we performed differential modification...
Co-repressor histone deacetylase 9 (HDAC9) plays a key role in the development and differentiation of many types cells, including regulatory T cells. However, biological function HDAC9 effector cells is unknown. Systemic autoimmune diseases like lupus, diabetes, rheumatoid arthritis have dysfunctional To determine systemic autoimmunity, we created MRL/lpr mice with deficiency that aberrant cell function. led to decreased lympho-proliferation, inflammation, autoantibody production, increased...
In future IoT big-data management and knowledge discovery for large scale industrial automation application, the importance of internet is increasing day by day. Several diversified technologies such as (Internet Things), computational intelligence, machine type communication, big-data, sensor technology can be incorporated together to improve data efficiency applications. So in this work, we need propose a Cognitive Oriented Big-data Framework (COIB-framework) along with implementation...
Artificial intelligence has rapidly grown and made the scenario that no field can function without it. Like every field, it also plays a vital role in sports nowadays. In certain sports, injuries happen very often due to heavy training sudden speedy actions, especially athletics football. Here arises need analyze effect of physical sportsperson by collecting data from their daily training. With help artificial intelligence, recurrent neural model is developed treatment concerning injury. A...
Dynamic changes in chromatin structure through ATP-dependent remodeling and covalent modifications on histones play important roles transcription regulation. Among the many modifiers identified, NuRD (nucleosome histone deacetylase) complex is unique because it possesses both nucleosome deacetylase activities. To understand biological function of complex, we generated a knock-out mouse model Mta2 (metastasis-associated protein 2) gene, which encodes NuRD-specific component. null mice...
This research addresses the challenge of automating skin disease diagnosis using dermatoscopic images. The primary issue lies in accurately classifying pigmented lesions, which traditionally rely on manual assessment by dermatologists and are prone to subjectivity time consumption. By integrating a hybrid CNN-DenseNet model, this study aimed overcome complexities differentiating various diseases diagnostic process effectively. Our methodology involved rigorous data preprocessing, exploratory...