A5088093750- Hydrogels: synthesis, properties, applications
- Radiopharmaceutical Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Peptidase Inhibition and Analysis
- Antimicrobial agents and applications
- Medical Imaging Techniques and Applications
- Polymer Surface Interaction Studies
- Nanoplatforms for cancer theranostics
- Supramolecular Self-Assembly in Materials
- Photodynamic Therapy Research Studies
- Proteoglycans and glycosaminoglycans research
- Lung Cancer Treatments and Mutations
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Advanced Drug Delivery Systems
- Advanced Polymer Synthesis and Characterization
- Porphyrin and Phthalocyanine Chemistry
- Click Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- HER2/EGFR in Cancer Research
- Electrochemical sensors and biosensors
- Marine Biology and Environmental Chemistry
- Semiconductor materials and devices
- Graphene and Nanomaterials Applications
Weifang University of Science and Technology
2025
Ocean University of China
2025
China Academy of Engineering Physics
2016-2024
National Health and Family Planning Commission
2024
Mianyang Central Hospital
2024
Affiliated Hospital of Southwest Medical University
2018-2022
Uppsala University
2010-2020
First Affiliated Hospital of Sichuan Medical University
2018
Wuhan University of Technology
2004-2017
Science for Life Laboratory
2014
Abstract Nanoclays have generated interest in biomaterial design for their ability to enhance the mechanics of polymeric materials and impart biological function. As well as utility physical cross-linkers, clays been explored sustained localization biomolecules promote vivo tissue regeneration. To date, both biomolecule-clay polymer-clay nanocomposite strategies utilised negatively charged clay particle surface. such, interactions are set competition, potentially limiting functional...
Functionalization of hyaluronic acid (HA) with orthogonally reactive aldehyde and thiol groups permitted simultaneous bioconjugation networking/nanostructuring the HA chains for potential use as local systemic delivery vehicles medical therapies. In one experiment, thiol–disulfide exchange reaction carbazone chemistry were employed to construct a disulfide hydrogel matrix macromolecules carbazone-linked poly(vinyl alcohol) prodrug doxorubicin (PVA–DOX). another orthogonal chemoselective...
The development of multimodal in situ cross-linkable hyaluronic acid nanogels hybridized with iron oxide nanoparticles is reported. Utilizing a chemoselective hydrazone coupling reaction, the are converted to macroscopic hybrid hydrogel without any additional reagent. Hydrophobic cargos remain encapsulated hydrophobic domains leakage. However, degradation hyaluronidase liberates nanoparticles. This allows utilization imaging agents as tracers degradation. UV-vis spectrometry and MRI studies...
We demonstrated that attenuated total reflectance terahertz time-domain spectroscopy (ATR THz-TDS) is able to monitor oxidative stress response of living human cells, which proven in this work it an efficient non-invasive, label-free, real-time and situ monitoring cell death. Furthermore, the dielectric constant loss cultured breast epithelial along with their evolution under induced by high concentration H2O2, were quantitatively determined work. Our observation results finally confirmed...
A modular approach for the synthesis of hyaluronic acid hydrogels using orthogonal chemoselective reactions subsequent enzymatic decomposition to nanoparticles is described.
The objective of this study was to develop an efficient and stable drug delivery nanocarrier based on a dually functionalized hyaluronic acid (HA) derivative which could be used as long circulating vehicle. Self-assembled HA nanoparticles (HA NPs) were prepared by attaching pyrene the backbone obtained physical NPs stabilized chemical cross-linking chains form hydrophobic core–hydrophilic shell NPs. Orthogonal chemoselective reactions applied for conversion into its amphiphilic subsequent...
We have developed a nanoprodrug that enables the uptake by cancer cells and subsequent intracellular activation. The is composed of cell-targeting biopolymer, hyaluronic acid (HA), an anti-cancer drug, camptothecin (CPT). chemical linkage between polymer drug stable outside cells, thus maintaining in "off" state. specific should then lead to environmental change results cleavage linkage, liberating entering "on" natural cancer-targeting biopolymer HA was modified with aldehyde "click"...
PMSA (prostate-specific membrane antigen) is currently the most significant target for diagnosing and treating PCa (prostate cancer). Herein, we reported a series 68Ga/177Lu-labeled multimer PSMA tracer conjugating with PEG chain, including [68Ga]Ga-DOTA-(1P-PEG4), [68Ga]Ga-DOTA-(2P-PEG0), [68Ga]Ga-DOTA-(2P-PEG4), [68Ga]Ga/[177Lu]Lu-DOTA-(2P-PEG4)2, which showed an advantage of multivalent effect PEGylation to achieve higher tumor accumulation faster kidney clearance. To figure out how...
beta-Cyclodextrin (beta-CD) hydrogel was prepared in a strong alkali condition using epichlorohydrin (EPI) as cross-linker, where the molar ratios of EPI to beta-CD were 8:1, 10:1, and 15:1. In order endow pH sensitivity hydrogel, naphthaleneacetic acid (NAA) loaded by taking advantage its hydrophobic interaction with cavities beta-CD. The releases blue dextran (a water-soluble dye) from hydrogels promoted, pHs media increased. When ratio lower, degrees release higher, dependency became more...
A number of oligo-p-phenylene-ethynylenes (OPEs) have exhibited excellent biocidal activity against both Gram-negative and Gram-positive bacteria. Although cell death may occur in the dark, these compounds are far more effective light as a result their abilities to generate cell-damaging reactive oxygen species. In this study, interactions four OPEs with Escherichia coli Staphylococcus aureus been investigated. Compared quaternary ammonium salts (Q-OPE), tertiary (T-OPE) effectively kill...
This study demonstrates, for the first time, that synthetic PEG‐based hydrogels can be cross‐linked reversibly by calcium upon functionalization of polymer backbone with bisphosphonate groups (BPs) allow formation strong coordination bonds divalent metal ions such as Mg 2+ and Ca . More specifically, it is shown BP‐functionalized shaped providing reversible physical cross‐linkers.
In order to develop ideal photosensitizers for photodynamic therapy (PDT), a thiazolium group was introduced in cyanine dyes possess the advantages of intense absorption visible region and anti-microbial activity. We evaluated anti-bacterial activity three against Staphylococcus aureus (Gram-positive bacteria) Escherichia coli (Gram-negative vitro. This is first time that such kinds are applied antibiotic area. Cyanines display excellent S. E. exposed white light irradiation, corresponding...