A5079035430- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Inflammatory Bowel Disease
- Gallbladder and Bile Duct Disorders
- Organ Transplantation Techniques and Outcomes
- Esophageal and GI Pathology
- Microscopic Colitis
- Celiac Disease Research and Management
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Diseases and Immunity
- Drug-Induced Hepatotoxicity and Protection
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Autoimmune and Inflammatory Disorders
- Magnesium Alloys: Properties and Applications
- Parasites and Host Interactions
- Cerebrospinal fluid and hydrocephalus
- Biosimilars and Bioanalytical Methods
- Chronic Lymphocytic Leukemia Research
- Parasitic infections in humans and animals
- Colorectal Cancer Screening and Detection
- Autoimmune Bullous Skin Diseases
- Gastrointestinal disorders and treatments
- Spinal Dysraphism and Malformations
- Cancer Diagnosis and Treatment
University of Coimbra
2017-2025
Administração Regional de Saúde de Lisboa e Vale do Tejo
2025
Hospitais da Universidade de Coimbra
2013-2023
University Gastroenterology
2017
Abstract Background The impact of coexistent IBD and PSC on disease progression prognosis is unclear. This study evaluates outcomes in patients with both conditions, using the novel Risk Estimate Tool (PREsTO) for prognosis. Methods A retrospective multicentric identified IBD-PSC through a national survey. PREsTO was calculated to predict PSC-related liver decompensation, tracked via composite outcome measures. Results Among 77 from six nationwide participating centres, 59 were included,...
Acute-on-chronic liver failure (ACLF) is defined by the development of acute deterioration function associated with other organs and high short-term mortality in patients chronic disease (CLD). There no consensus on diagnostic criteria, its independence from ordinary decompensation CLD has frequently been questioned. This study aimed to identify characterize this condition test CLIF-C OF score comparing it 2016-MELD (with sodium) Child-Pugh.
diarrhea and hematochezia.The patient had a history of chronic myelogenous leukemia (CML), depression, high blood pressure, obstructive sleep apnea.He was receiving dasatinib for the CML two half years, following previous imatinib therapy that failed due to drug resistance.Hematological remission been achieved with 2 months prior gastroenterological consultation.A control colonoscopy performed showed colonic loss normal submucosal vascular pattern multiple areas characterized by edema,...
Bacterial infections are frequent in cirrhosis and may induce other deleterious complications. Ultrasensitive C-reactive protein (US-CRP), like acute-phase proteins, is often considered useful predicting bacterial infection decompensated cirrhosis. However, US-CRP's reliability remains inconclusive, as inflammation causes US-CRP synthesis independently of infection. The aim this study was to clarify role an predictor cirrhosis.This a prospective single-center with systematic inclusion...
Although endoscopic retrograde cholangiopancreatography (ERCP) is an essential procedure used to treat conditions affecting the biliopancreatic system, it can lead several complications. Post-ERCP pancreatitis (PEP) most frequent one, with incidence ranging from 3 14%. Our aim was assess potential risk factors associated PEP occurrence in patients undergoing ERCP indomethacin prophylaxis.Prospective, single-center, real-world observational study (January December 2015) inclusion of submitted...
The authors report the case of a 41-year-old woman with colonic perforation due to ventriculoperitoneal shunt (VPS) catheter. Left-sided was diagnosed by abdominal computed tomography 28 years after placement, following acute meningitis caused <i>Escherichia coli</i>. proximal end VPS exteriorized and it decided remove distal colonoscopy. After pulling out catheter polypectomy snare, broke at site where entering colon, leaving small in wall which closed 2 endoclips. endoluminal...
A patient is admitted with complaints of recent onset nausea, discomfort, jaundice and blood tests that reveal severe hepatitis. At the time, she had been taking medication Hypericum perforatum (St John's wort) for 6 months, weeks before this event, took flupirtine maleate. few days after being admitted, developed encephalopathy progressing to acute liver failure (ALF) requiring unsuccessful transplantation. The was ultimately diagnosed drug-induced injury (DILI). In context, while H. could...
Introduction: Several studies have highlighted the potential benefits of early prophylactic transjugular intrahepatic portosystemic shunt (preemptive TIPS) placement in reducing morbidity and mortality following variceal bleeding (VB). Baveno VII recommends its less than 72 h after VB (Child-Pugh class C &lt;14 or B &gt;7 plus active bleeding). This study aimed to evaluate effectiveness preemptive TIPS compared a control group referral center. Methods: The included cirrhotic patients...
Intramural duodenal haematoma (IDH) is an uncommon occurrence following endoscopic intervention, specifically retrograde cholangiopancreatography (ERCP), and typically attributed to blunt trauma caused by the endoscope.[1 2][1] IDH generally resolves spontaneously with supportive care
Acute liver failure is an uncommon condition associated with a high mortality. Most patients do not survive without transplantation. In the last decades, auxiliary transplantation has emerged as therapeutic option.The authors present two cases of acute that required Given patients' young age and preserved macroscopic pattern evaluated in surgery, was executed using different surgical approaches. Afterwards, following confirmed full native regeneration, were submitted to hepatectomy, which...
Cholangitis is a common clinical entity. from hydatid disease far less common. We present case of acute cholangitis caused by cystobiliary communications in patient with disseminated hydatidosis. Treatment such cases usually combined endoscopic and surgical approach. In this case, surgery was contraindicated cholangiopancreatography provided the last source for adequate biliary drainage.
According to the guideline published by ESGE/UEG, a high-quality esophagogastroduodenoscopy (EGD) implies application of some criteria that enable better healthcare outcomes. Although intra-procedural performance measures are dependent on patient factors, there is no reference sedation practices in mentioned above.
Background: Recent developments concerning the quantification of anti-TNF-α therapies and auto-induced antibodies screening are crucial in inflammatory bowel disease (IBD) treatment. The formation anti-infliximab (AIA) associated with poor control. We aimed to assess if higher infliximab trough levels correlate long term remission status. wanted test hypothesis different cut-offs early chronic therapy. Our objective also concerned relevance AIA preponderance factors (such as use...
Immunogenicity directed to infliximab (IFX) administration can lead secondary loss of response with the formation anti-infliximab antibodies (AIA). Immunomodulators may play a role in reducing immunogenicity inflammatory bowel disease (IBD). We aimed identify differences IFX between Crohn’s (CD) and ulcerative colitis (UC). also evaluate immunomodulators - combined therapy (CT) clarify both diseases. Single-centre retrospective cohort study based on patients IBD treated infliximab. Remission...
Monitoring of infliximab therapy in inflammatory bowel disease (IBD) is well established. As for adalimumab, there less consolidated data. This study aimed to evaluate the usefulness adalimumab trough levels (ATL) and serum anti-adalimumab antibodies (AAA) control Crohn's (CD). a retrospective assessing patients with CD treated followed tertiary hospital. Remission was defined as absence symptoms C-reactive protein (CRP) value ≤ 0.5 mg/dl. All were on treatment at least eight weeks. Drug...
Parastomal variceal bleeding (PVB) is a recognized complication of ostomized patients in the presence portal hypertension. However, since there are few reported cases, therapeutic algorithm has not yet been established.A 63-year-old man, who had undergone definitive colostomy, recurrently presented to emergency department hemorrhage bright red blood from his colostomy bag, initially assumed be caused by stoma trauma. Accordingly, temporary success on local approaches such as direct...
Aims Post-polypectomy syndrome (PPS) is an uncommon complication of colonoscopic polypectomy using eletrocoagulation. It defined as persistent abdominal pain post-intervention without free intestinal perforation. Little known about risk factors. The aim this study was to characterize the in a Portuguese tertiary referral center.
Aims Acute cholangitis with organ failure has a mortality rate of around 100 % if rapid decompression the bile duct does not occur. The aim present study was to evaluate role endoscopic retrograde cholangiopancreatography (ERCP) in emergent drainage at tertiary referral center.