A5044793178- Atmospheric aerosols and clouds
- Dementia and Cognitive Impairment Research
- Optical Polarization and Ellipsometry
- RNA Interference and Gene Delivery
- Optical and Acousto-Optic Technologies
- Medical Imaging Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Frailty in Older Adults
- Marine and coastal ecosystems
- Alzheimer's disease research and treatments
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Treatments and Mutations
- Nanoplatforms for cancer theranostics
- Diatoms and Algae Research
- RNA and protein synthesis mechanisms
- Radioactive Decay and Measurement Techniques
- Water Quality Monitoring and Analysis
- Machine Learning in Bioinformatics
- Aeolian processes and effects
- Quantum Mechanics and Non-Hermitian Physics
- Ovarian cancer diagnosis and treatment
- Remote Sensing and LiDAR Applications
- Water Resources and Management
- Oil Spill Detection and Mitigation
- Numerical methods in inverse problems
Federal Medical-Biological Agency
2017-2023
Institute of Computational Modeling
1999-2005
Russian Academy of Sciences
1999-2000
Institute of Biophysics
1999
Here, we present DNA aptamers capable of specific binding to glial tumor cells in vitro, ex vivo, and vivo for visualization diagnostics central nervous system tumors. We selected the specifically postoperative human primary tumors not healthy brain meningioma, using a modified process systematic evolution ligands by exponential enrichment cells; sequenced analyzed ssDNA pools bioinformatic tools identified best their abilities; determined three-dimensional structures lead (Gli-55 Gli-233)...
Aptamers acting as the basis for radiopharmaceutical drugs based on carbon-11 have proven themselves to be highly sensitive and specific agents imaging tumors metastases. However, lack of knowledge about patterns their metabolism in body radiation exposure organs significantly hinders clinical use. To fill this gap, a study biodistribution radiolabeled aptamer LC-18, well an assessment tissues vivo were carried out. Purpose: evaluate doses organs, whole during intravenous administration...
Novel nanoscale bioconjugates combining unique plasmonic photothermal properties of gold nanoparticles (AuNPs) with targeted delivery using cell-specific DNA aptamers have a tremendous potential for medical diagnostics and therapy many cell-based diseases. In this study, we demonstrate the high anti-cancer activity aptamer-conjugated, 37-nm spherical toward Ehrlich carcinoma in tumor-bearing mice after treatment. The synthetic anti-tumor bring precisely to desired cells selectively eliminate...
Identification of primary tumors and metastasis sites is an essential step in cancer diagnostics the following treatment. Positron emission tomography-computed tomography (PET/CT) one most reliable methods for scanning whole organism malignancies. In this work, we synthesized 11C-labeled oligonucleotide primer hybridized it to anti-cancer DNA aptamer. The 11C-aptamer was applied vivo imaging Ehrlich ascites carcinoma its metastases mice using PET/CT. experiments with determined very small...
ДИАГНОСТИКА БОЛЕЗНИ АЛЬЦГЕЙМЕРА С ИСПОЛЬЗОВАНИЕМ ПЭТ/КТ: КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕС
The article describes a clinical case of female Alzheimer disease patient at an early stage the neurodegenerative process. did not have any complaints. She was taken to neuropsychologists by her husband that concerned because patient's family history (his mother-in-law suffered Alzheimer's disease) and emergence some memory problems in his wife. diagnosis suspected based on results neuropsychological evaluation cognitive functions which corresponded mild impairment. To confirm presence brain...
Characteristics of organic–mineral complexes have been theoretically and experimentally studied in the paper, based on method integral light scattering indicatrix. Modelling optical properties was realized using models coated spherical particles with a shell which is constant changeable refractive index profile. General regularities revealed generalized parameters for indicatrix suggested.
ФГБОУ ВО Красноярский государственный медицинский университет имени проф.В. Ф
5© ЧАНЧИКОВА Н. Г
The article describes a clinical case of female Alzheimer disease patient at an early stage the neurodegenerative process. did not have any complaints. She was taken to neuropsychologists by her husband that concerned because patient's family history (his mother-in-law suffered Alzheimer's disease) and emergence some memory problems in his wife. diagnosis suspected based on results neuropsychological evaluation cognitive functions which corresponded mild impairment. To confirm presence brain...
In summer periods 1989−1994, a complex of hydrobiological investigations in the middle reaches Yenisei river (Krasnoyarsk region) and its main tributaries were performed. Spatial distribution, quantitative, taxonomic characteristics phytoplankton, bacterio- phytoperiphyton, saprobicity indications, production-destruction intensity under study. Proceeding from these data, waters basin are classified as mesotrophic, corresponding to quality class 3 ('satisfactory pure').