A5013140057- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Dementia and Cognitive Impairment Research
- Radiomics and Machine Learning in Medical Imaging
- Frailty in Older Adults
- RNA Interference and Gene Delivery
- Lung Cancer Treatments and Mutations
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Human Health and Disease
- Advanced biosensing and bioanalysis techniques
- Neurological disorders and treatments
- Machine Learning in Bioinformatics
- Kidney Stones and Urolithiasis Treatments
- Scientific Research and Studies
- Lymphoma Diagnosis and Treatment
- Paleopathology and ancient diseases
- Effects and risks of endocrine disrupting chemicals
- Heavy Metal Exposure and Toxicity
- Breast Cancer Treatment Studies
- Chemical Reactions and Isotopes
- Recycling and Waste Management Techniques
- Genetic Neurodegenerative Diseases
- Advanced X-ray and CT Imaging
- Nanoplatforms for cancer theranostics
Krasnoyarsk State Medical University
2017-2022
Federal Medical-Biological Agency
2017-2021
Nuclear and Radiation Safety Center
2020
Krasnoyarsk Regional Clinical Hospital
2019
Bogomolets National Medical University
2015
Novel nanoscale bioconjugates combining unique plasmonic photothermal properties of gold nanoparticles (AuNPs) with targeted delivery using cell-specific DNA aptamers have a tremendous potential for medical diagnostics and therapy many cell-based diseases. In this study, we demonstrate the high anti-cancer activity aptamer-conjugated, 37-nm spherical toward Ehrlich carcinoma in tumor-bearing mice after treatment. The synthetic anti-tumor bring precisely to desired cells selectively eliminate...
Identification of primary tumors and metastasis sites is an essential step in cancer diagnostics the following treatment. Positron emission tomography-computed tomography (PET/CT) one most reliable methods for scanning whole organism malignancies. In this work, we synthesized 11C-labeled oligonucleotide primer hybridized it to anti-cancer DNA aptamer. The 11C-aptamer was applied vivo imaging Ehrlich ascites carcinoma its metastases mice using PET/CT. experiments with determined very small...
ДИАГНОСТИКА БОЛЕЗНИ АЛЬЦГЕЙМЕРА С ИСПОЛЬЗОВАНИЕМ ПЭТ/КТ: КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕС
Study Objective: To determine, based on data from examination of apparently healthy subjects, parameter reference values for 18F-DOPA positron emission tomography (PET) the brain. Design: This was a prospective study. Materials and Methods: Apparently subjects (n = 33) underwent PET brain using Discovery PET/CT 600 scanner. Data were processed standard statistical methods. The Shapiro-Wilk test used to distribution normality, Pearson Spearman covariance correlation matrices calculated. key...
The article describes a clinical case of female Alzheimer disease patient at an early stage the neurodegenerative process. did not have any complaints. She was taken to neuropsychologists by her husband that concerned because patient's family history (his mother-in-law suffered Alzheimer's disease) and emergence some memory problems in his wife. diagnosis suspected based on results neuropsychological evaluation cognitive functions which corresponded mild impairment. To confirm presence brain...
Aim . To determine the diagnostic value of positron emission tomography (PET)/computed (CT) with F-18 fluorodeoxyglucose ( 18 F-FDG) for monitoring effectiveness and prognosis lymphoma therapy. Materials methods. Retrospective data F-FDG PET/CT (before treatment (PET1), after two cycles (PET2), completion chemotherapy (PET3)) in 30 people lymphomas were analyzed. Results. A complete metabolic response PET2 (PET2–) was observed 21 patients (70%). In 9 PET2–, a partial (6 people), lack (2 or...
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ФГБОУ ВО Красноярский государственный медицинский университет имени проф.В. Ф
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The article describes a clinical case of female Alzheimer disease patient at an early stage the neurodegenerative process. did not have any complaints. She was taken to neuropsychologists by her husband that concerned because patient's family history (his mother-in-law suffered Alzheimer's disease) and emergence some memory problems in his wife. diagnosis suspected based on results neuropsychological evaluation cognitive functions which corresponded mild impairment. To confirm presence brain...
Timely and accurate diagnosis of focal lesions the liver, despite existing arsenal radiation examination modalities, still remains a challenge. Particular difficulty is caused by foci small diameter, an atypical character contrasting; combination multiple formations different genesis; focus against background diffuse liver damage; damage, mimicking tumors. DECT method givesnew analysis algorithms that are from traditional CT. The article presents review literature on use qualitative...
Background . Standard imaging techniques, including chest x-ray, ultrasonography, magnetic resonance and computed tomography have some limitations in terms of their ability to detect distant metastases. The purpose the study was search for additional diagnostic techniques breast cancer detection. M aterial methods. Results 18 F-FDG PET/scans were retrospectively analyzed 50 patients. R esults. Traditional showed suspicion metastases 29 Of them, metastatic disease histologically confirmed 16...
Abstract PET investigation of human brain for the purposes effective diagnostics some neurodegenerative diseases requires definition normal indices. Here we present figures to be used as reference values necessary indices in medical investigations.
Positron-emission tomography is powerful but costly tool for various medical investigations. In particular, it used in Parkinson's disease and essential tremor diagnostics. However, yet there no standardized figures of the references, it. We examined PET analysis carried out healthy people those with disease. The obtained data allowed to identify informative retrieved from observations define norm people. Also, high efficiency as approved.
Background . Neoadjuvant chemotherapy (NACT) is an important stage in the treatment of patients with breast cancer. Positron emission tomography/computed tomography (PET/СT) fluorodeoxyglucose labeled 18 F ( F-FDG) widely used as effective method metabolic tumor imaging at stages treatment. The aim this study was to evaluate possibility using PET/CT F-FDG determine early response NACT. Materials and methods results 27 cancer were retrospectively analyzed. performed before start NACT, after 2...