A5089725663- Boron and Carbon Nanomaterials Research
- Graphene research and applications
- Advanced biosensing and bioanalysis techniques
- Fullerene Chemistry and Applications
- RNA Interference and Gene Delivery
- bioluminescence and chemiluminescence research
- Carbon Nanotubes in Composites
- MXene and MAX Phase Materials
- Photochemistry and Electron Transfer Studies
- 2D Materials and Applications
- DNA and Nucleic Acid Chemistry
- Semiconductor materials and interfaces
- Photoreceptor and optogenetics research
- Advancements in Battery Materials
- Magnetic and transport properties of perovskites and related materials
- Nanoparticle-Based Drug Delivery
- Molecular Junctions and Nanostructures
- Free Radicals and Antioxidants
- Organic Electronics and Photovoltaics
- ZnO doping and properties
- Insect Pheromone Research and Control
- Diamond and Carbon-based Materials Research
- Insect and Pesticide Research
- Topological Materials and Phenomena
- Electrocatalysts for Energy Conversion
Institute of Physics
2015-2024
Siberian Federal University
2014-2024
Krasnoyarsk Scientific Center
2001-2024
Russian Academy of Sciences
2001-2022
Siberian Branch of the Russian Academy of Sciences
2012-2022
Institute of Chemistry and Chemical Technology
2001-2021
National Research Tomsk State University
2020-2021
Institute of Physics of the Slovak Academy of Sciences
2020
Czech Academy of Sciences, Institute of Physics
2016
The spread of COVID-19 has affected billions people across the globe, and diagnosis viral infection still needs improvement. Because high immunogenicity abundant expression during infection, SARS-CoV-2 nucleocapsid (N) protein could be an important diagnostic marker. This study aimed to develop a label-free optical aptasensor fabricated with novel single-stranded DNA aptamer detect N protein. N-binding aptamers selected using asymmetric-emulsion PCR-SELEX their binding affinity...
Half-metallic ferromagnetic materials with planar forms are promising for spintronics applications. A wide range of 2D lattices like graphene, h-BN, transition metal dichalcogenides, etc. non-magnetic or weakly magnetic. Using first principles calculations, the existence graphene-like hexagonal chromium nitride (h-CrN) an almost flat atomically thin structure is predicted. We find that freestanding h-CrN has a 100% spin-polarized half-metallic nature possible ordering and high rate optical...
Aptamer selection against novel infections is a complicated and time-consuming approach. Synergy can be achieved by using computational methods together with experimental procedures. This study aims to develop reliable methodology for rational aptamer in silico et vitro design. The new approach combines multiple steps: (1) Molecular design, based on screening DNA library directed mutagenesis fit the protein tertiary structure; (2) 3D molecular modeling of target; (3) docking an protein; (4)...
Here, we present DNA aptamers capable of specific binding to glial tumor cells in vitro, ex vivo, and vivo for visualization diagnostics central nervous system tumors. We selected the specifically postoperative human primary tumors not healthy brain meningioma, using a modified process systematic evolution ligands by exponential enrichment cells; sequenced analyzed ssDNA pools bioinformatic tools identified best their abilities; determined three-dimensional structures lead (Gli-55 Gli-233)...
Nanotechnologies involving physical methods of tumor destruction using functional oligonucleotides are promising for targeted cancer therapy. Our study presents magnetodynamic therapy selective elimination cells in vivo DNA aptamer-functionalized magnetic nanoparticles exposed to a low frequency alternating field. We developed an enhanced targeting approach with aptamers and arabinogalactan. Aptamers fibronectin (AS-14) heat shock cognate 71 kDa protein (AS-42) facilitated the delivery...
Gadolinium (Gd)-containing fullerenols are perspective agents for magnetic resonance imaging and cancer research. They combine the unique paramagnetic properties of Gd with solubility in water, low toxicity antiradical activity fullerenols. We compared bioeffects two Gd-containing a different number oxygen groups—20 42: Gd@C82O20H14 Gd@C82O42H32. The bioluminescent bacteria-based assay was applied to monitor fullerenols, bioluminescence as signal physiological parameter, bacterial...
The absorption energy and diffusion rates of lithium atoms inside graphitelike boron carbide (BC${}_{3}$) crystal are investigated by the ab initio pseudopotential density-functional method using generalized gradient approximation. It is shown that may effectively intercalate this structure with maximum concentration corresponding to Li${}_{2}$BC${}_{3}$ stoichiometry, which threefold in comparison graphite. potential barrier values for both at low about 0.19 eV, so BC${}_{3}$ can move...
Introduction: Breast cancer (BC) diagnostics lack noninvasive methods and procedures for screening monitoring disease dynamics. Admitted CellSearch® is used fluid biopsy capture of circulating tumor cells only epithelial origin. Here we describe an RNA aptamer (MDA231) detecting BC in clinical samples, including blood. The MDA231 was originally selected against triple-negative breast cell line MDA-MB-231 using cell-SELEX. Methods: structure solution predicted mFold program molecular dynamic...
Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as synthetic analogs of antibodies and bind to a target molecule with high specificity.Aptamer affinity entirely depends on its tertiary structure charge distribution.Therefore, length optimization essential for increasing aptamer specificity affinity.Here, we present general procedure finding the most populated atomistic structures aptamers.Based existed LC-18 lung adenocarcinoma, new truncated (LC-18t)...
Identification of primary tumors and metastasis sites is an essential step in cancer diagnostics the following treatment. Positron emission tomography-computed tomography (PET/CT) one most reliable methods for scanning whole organism malignancies. In this work, we synthesized 11C-labeled oligonucleotide primer hybridized it to anti-cancer DNA aptamer. The 11C-aptamer was applied vivo imaging Ehrlich ascites carcinoma its metastases mice using PET/CT. experiments with determined very small...
Gd endohedral complexes of C82 fullerenols were synthesized and mass spectrometry analysis their composition was carried out. It established that the synthesis yields a series Gd@C82Ox(OH)y (x = 0, 3; y 8, 16, 24, 36, 44). The atomic electronic structure properties investigated using density functional theory calculations. shown presence gadolinium increases reactivity fullerenols. is proposed high-spin are promising candidates for application in magnetic resonance imaging.
Ca2+-triggered coelenterazine-binding protein (CBP) is a natural form of the luciferase substrate involved in Renilla bioluminescence reaction. It stable complex coelenterazine and apoprotein that, unlike coelenterazine, soluble an aquatic environment yields significantly higher bioluminescent signal. This makes CBP convenient for luciferase-based vitro assay. In search similar NanoLuc, furimazine-apoCBP was prepared verified against furimazine, CBP. Furimazine-apoCBP relatively solution...
Using palladium-catalyzed Suzuki polycondensation, we synthesized new light-emitting fluorene copolymers containing the dicyano derivatives of stilbene and phenanthrene characterized them by gel permeation chromatography, UV-vis absorption spectroscopy, spectrofluorimetry, cyclic voltammetry. The photoluminescence spectra polymers show significant energy transfer from segments to dicyanostilbene 9,10-dicyanophenanthrene units, which is in agreement with data theoretical calculations. OLEDs...
The atomic and electronic structures of a set proposed pentagonal thin ($1.6\phantom{\rule{0.3em}{0ex}}\mathrm{nm}$ in diameter) silicon/silica quantum nanodots (QDs) nanowires (NWs) with narrow interface, as well parent metastable silicon ($1.2\phantom{\rule{0.3em}{0ex}}\mathrm{nm}$ diameter), were studied using cluster $\mathrm{B}3\mathrm{LYP}∕6\text{\ensuremath{-}}31{\mathrm{G}}^{*}$ periodic boundary condition (PBC) plane-wave (PW) pseudopotential (PP) local-density approximation...
We analyze a new type of plasmon system arising from small metal nanoparticles linked by narrow conductive molecular bridges. In contrast to the well-known charge-transfer plasmons, bridge in these systems consists only molecule or polymer which electrons move ballistic mode, showing quantum effects. The plasmonic is studied an original hybrid quantum-classical model accounting for effects, with main parameters obtained first-principles density functional theory simulations. have derived...
C-Met protein is a glycosylated receptor tyrosine kinase of the hepatocyte growth factor (HGF), composed an α and β chain. Upon ligand binding, transmits intracellular signals by unique multi-substrate docking site. can be aberrantly activated leading to tumorigenesis other diseases, has been recognized as biomarker in cancer diagnosis. aptamers have recently considered useful tool for detection biomarkers. Herein we report molecular interaction study human expressed kidney cells with two...
Aptamers are currently being investigated for their potential to improve virotherapy. They offer several advantages, including the ability prevent aggregation of viral particles, enhance target specificity, and protect against neutralizing effects antibodies. The purpose this study was comprehensively investigate an aptamer capable enhancing This involved characterizing previously selected vaccinia virus (VACV), evaluating molecular interaction optimized aptamers with recombinant oncolytic...