A5093927368- Virus-based gene therapy research
- Cancer Research and Treatments
- Cytomegalovirus and herpesvirus research
- Bacteriophages and microbial interactions
- Viral Infectious Diseases and Gene Expression in Insects
- CAR-T cell therapy research
Institute of Chemical Biology and Fundamental Medicine
2024
Siberian Branch of the Russian Academy of Sciences
2024
Novosibirsk State University
2024
Virotherapy is one of the perspective technologies in treatment malignant neoplasms. Previously, we have developed oncolytic vaccinia virus VV-GMCSF-Lact and its high cytotoxic activity antitumor efficacy against glioma was shown. In this work, using immortalized patient-derived cells with different sensitivity to VV-GMCSF-Lact, evaluated effect chemotherapy agents. Additionally, studied combination temozolomide which most preferred drug for treatment. Experimental results indicate that...
Aptamers are currently being investigated for their potential to improve virotherapy. They offer several advantages, including the ability prevent aggregation of viral particles, enhance target specificity, and protect against neutralizing effects antibodies. The purpose this study was comprehensively investigate an aptamer capable enhancing This involved characterizing previously selected vaccinia virus (VACV), evaluating molecular interaction optimized aptamers with recombinant oncolytic...
When studying the action of oncolytic virus VV-GMCSF-Lact, including contribution GMCSF to oncotoxic effect drug, a pronounced immune response due both and influence was observed on model subcutaneously transplanted GL-261 murine glioma. Immune cell populations animals treated with rhGMCSF rmGMCSF were characterized in comparison from control groups.