A5077038933- Parkinson's Disease Mechanisms and Treatments
- Molecular Biology Techniques and Applications
- RNA regulation and disease
- Prion Diseases and Protein Misfolding
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Animal Genetics and Reproduction
- RNA Interference and Gene Delivery
- Plant-Microbe Interactions and Immunity
- Hydrogels: synthesis, properties, applications
- Alzheimer's disease research and treatments
- Advanced Drug Delivery Systems
- Legume Nitrogen Fixing Symbiosis
- Transgenic Plants and Applications
- Nanoparticle-Based Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Plant Virus Research Studies
- biodegradable polymer synthesis and properties
- Virus-based gene therapy research
- Plant tissue culture and regeneration
- Enzyme Catalysis and Immobilization
- HIV Research and Treatment
- Advanced Glycation End Products research
- Ion Channels and Receptors
- Innovative Microfluidic and Catalytic Techniques Innovation
Lomonosov Moscow State University
2012-2024
Moscow State University
2012-2023
Vavilov Institute of General Genetics
2017
Russian Academy of Sciences
2012-2014
Many plants release airborne volatile compounds in response to wounding due pathogenic assault. These serve as plant defenses and are involved signaling. Here, we study the effects of pectin methylesterase (PME)-generated methanol from wounded ("emitters") on defensive reactions neighboring "receiver" plants. Plant leaf resulted synthesis PME a spike released into air. Gaseous or vapors PME-transgenic induced resistance bacterial pathogen Ralstonia solanacearum leaves non-wounded In...
The mechanical damage that often precedes the penetration of a leaf by pathogen promotes activation pectin methylesterase (PME); PME leads to emission methanol, resulting in "priming" effect on intact leaves, which is accompanied an increased sensitivity Tobacco mosaic virus (TMV) and resistance bacteria. In this study, we revealed mRNA levels methanol-inducible gene encoding Nicotiana benthamiana aldose 1-epimerase-like protein (NbAELP) leaves plants are very low compared with roots....
Parkinson’s disease (PD) is a widespread neuronal degenerative disorder with unexplored etiology. It associated various pathological events. In particular, the prefrontal cortex Brodmann area 9 (BA9) region affected in PD. This frontal lobe brain plays an important role cognitive, motor, and memory-related functions. BA9 develops Lewy bodies PD patients shows essential changes transcriptome proteome, connected mitochondria related pathways, protein folding metallothioneins. Recently, altered...
Plants are widely used for food and beverage preparation, most often in the form of complex mixtures dried ground parts, such as teas, spices or herbal medicines. Quality control products is important due to potential health risks from presence unlabelled components absence claimed ones. A promising approach analyse DNA metabarcoding its high resolution sensitivity. However, this method's application analysis requires several methodology optimizations extraction, amplification library...
Cellular dysfunction during Parkinson's disease leads to neuroinflammation in various brain regions, inducing neuronal death and contributing the progression of disease. Different ion channels may influence process neurodegeneration. The peptides Ms 9a-1 APHC3 can modulate function TRPA1 TRPV1 channels, we evaluated their cytoprotective effects differentiated dopaminergic neuron-like SH-SY5Y cells. We used stable neuroblastoma cell lines SH-SY5Y, producing wild-type alpha-synuclein its...
Sperm sexing is a technique for spermatozoa sorting into populations enriched with X- or Y-chromosome-bearing cells and widely used in the dairy industry. Investigation of characteristics sorted semen practical interest, because it could contribute to enhancement sexed fertility characteristics, which are currently lower than those conventional semen. Comparison population X-chromosome-bearing mixed also intriguing context potential differences that drive mechanisms primary sex-ratio...
This review presents information on the biochemical features of spermatozoa bearing an X or Y chromosome, enabling to obtain a sperm fraction with pre-defined sex chromosome. Almost only technology currently used for such separation (called sexing) is based fluorescence-activated cell sorting in regard DNA content. Besides its applications, this made it possible analyze properties isolated populations In recent years, number works have appeared proving existence differences between these at...
The chimeric protein TRIM5α-HRH is a promising antiviral factor for HIV-1 gene therapy. This able to protect cells from by blocking the virus in cytoplasm. We are developing protocol of therapy, which involves delivery into CD4^(+) T-lymphocytes lentiviral vectors (LVs). However, LVs containing have low infectious titer, prevents effective T cell modification. Here, we found that expression during pseudoviral particle production HEK293 cells, as well presence Eflα promoter our construction...
The controllable delivery of drugs is a key task pharmacology. For this purpose, series polymer composites was synthesized via the cross-linking hyaluronate and hyaluronate/polyacrylate mixture with Fe2O3 nanoparticles. imparts magnetic properties to composites, which are more pronounced for ternary hyaluronate/polyacrylate/γ-Fe2O3 compared binary hyaluronate/Fe2O3 composites. When dispersed in water, produce microsized hydrogel particles. Circulation microgels an aqueous solution at speed...