A5086070010- Drug Transport and Resistance Mechanisms
- Bone Tissue Engineering Materials
- Smart Grid Energy Management
- Herpesvirus Infections and Treatments
- Economic Growth and Productivity
- Orthopedic Infections and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Infectious Diseases and Tuberculosis
- Capital Investment and Risk Analysis
- Liver Disease Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Pediatric Hepatobiliary Diseases and Treatments
- Electron and X-Ray Spectroscopy Techniques
- Advanced X-ray Imaging Techniques
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactivity Studies
- Nicotinic Acetylcholine Receptors Study
- Cancer Research and Treatments
- Education, Psychology, and Social Research
- Analytical Chemistry and Chromatography
- Cholinesterase and Neurodegenerative Diseases
- Fiscal Policy and Economic Growth
- Pesticide Exposure and Toxicity
- Electric Power System Optimization
- Pharmacological Effects and Toxicity Studies
Charles University
2020-2025
Masaryk University
2023-2024
Central European Institute of Technology
2023
Central European Institute of Technology – Masaryk University
2023
University Hospital Hradec Králové
2021
Cholestatic liver diseases are characterized by intrahepatic accumulation of bile acids (BAs), exacerbating inflammation, and fibrosis. Dimethyl fumarate (DMF) is a clinically approved antiinflammatory drug that demonstrated protective effects in several experimental models injury. Still, its effect on BA homeostasis fibrosis has not been thoroughly studied. Herein, we hypothesized DMF could improve mitigate the progression cholestasis-induced The was administered to mice with...
Materials used for orthopedic implants should not only have physical properties close to those of bones, durability and biocompatibility, but also exhibit a sufficient degree antibacterial functionality. Due its excellent properties, titanium is still widely material production implants, the unmodified exhibits poor activity. In this work, physicochemical characteristics, such as chemical composition, crystallinity, wettability, roughness, release Ti ions surface modified with nanotubular...
Multidrug resistance-associated protein 2 (Mrp2) mediates biliary secretion of anionic endobiotics and xenobiotics. Genetic alteration Mrp2 leads to conjugated hyperbilirubinemia predisposes the development intrahepatic cholestasis pregnancy (ICP), characterized by increased plasma bile acids (BAs) due mechanisms that are incompletely understood. Therefore, this study aimed characterize BA metabolomics during experimental deficiency ICP. ICP was modeled ethinylestradiol (EE) administration...
Abstract As the consumption of implants increases, so do requirements for individual types implants, example, improved biocompatibility or longevity. Therefore, nano‐modification titanium surface is often chosen. The aim was to characterize modified with a focus on medical applications. by anodic oxidation method form nanotubes. Subsequently, material characterized and analyzed applications—surface morphology, wettability, chemical composition, release ions into biological fluids. A human...
In this study, a new series of aliphatic, cyclic, and heterocyclic derivatives haemanthamine was designed synthesized to enhance its inhibitory effect on the proliferation viability cancer cells. A library subjected 10 μM single-dose cytotoxicity screening against panel human cell lines various histotypes. Initial evaluation parent (1) twenty-nine (2–30) semisynthetic analogues showed that for some newly formed derivatives, certain cytotoxic observed, in one case even higher than compound....