A5071040960- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Adipose Tissue and Metabolism
- Surgical site infection prevention
- Neurogenesis and neuroplasticity mechanisms
- Biochemical effects in animals
- S100 Proteins and Annexins
- Neuroscience and Neuropharmacology Research
- Neurosurgical Procedures and Complications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Hemodynamic Monitoring and Therapy
- Plant-based Medicinal Research
- Central Venous Catheters and Hemodialysis
- Alzheimer's disease research and treatments
- Advanced Glycation End Products research
University Medical Center of the Johannes Gutenberg University Mainz
2013-2024
Johannes Gutenberg University Mainz
2013-2024
Tissue sampling for gene expression analysis is usually performed under general anesthesia. Anesthetics are known to modulate hemodynamics, receptor-mediated signaling cascades, and outcome parameters. The present study determined the influence of anesthetic paradigms typically used euthanization tissue on cerebral mRNA in mice. Naïve mice animals with acute traumatic brain injury induced by controlled cortical impact (CCI) were randomized following euthanasia protocols (n=10-11/group): no...
Limited data are available on the influence of sedation for critical care therapy with widely used anesthetic propofol recovery from acute traumatic brain injury. To establish endogenous neurogenesis and functional after injury, rats were sedated either during or 2 hours experimental injury.Randomized controlled animal study.University research laboratory.One hundred sixteen male Sprague Dawley rats.Mechanical lesion by cortical impact.This study investigated dose-dependent (36 72 mg/kg/hr)...
Oxidative stress is thought to be one of the main mediators neuronal damage in human neurodegenerative disease. Still, dissection causal relationships has turned out remarkably difficult. Here, we have analyzed global protein oxidation terms carbonylation membrane proteins and cytoplasmic three different mammalian species: aged cortex cerebellum from patients with or without Alzheimer's disease, mouse young old animals, adult rat hippocampus subjected not cerebral ischemia. Most tissues...
In animal research, authorities require a classification of anticipated pain levels and perioperative analgesia protocol prior to approval the experiments. However, data on this topic is rare so reported use analgesics. We determined surrogate parameters general well-being after subarachnoid hemorrhage (SAH), as well potential for improvement by different systemic paradigms. Brain injury was induced filament perforation mimic SAH. Sham-operated mice were included surgical control groups with...
Traumatic brain injury (TBI) is characterized by complex secondary processes involving the p75 neurotrophin receptor (p75NTR), which has been proposed as a possible therapeutic target. However, pathogenic role of p75NTR co-receptor sortilin in TBI not investigated. In this study, we examined whether contributes to acute and early using murine controlled cortical impact (CCI) model TBI. Initial expression analysis showed down-regulation mRNA levels 1 5 day post (dpi) reduced protein dpi....