A5087899166- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Autophagy in Disease and Therapy
- Respiratory viral infections research
- Atomic and Subatomic Physics Research
- Lung Cancer Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Cancer-related Molecular Pathways
- Sarcoidosis and Beryllium Toxicity Research
- Gestational Trophoblastic Disease Studies
- Kruppel-like factors research
- Cellular transport and secretion
- Ubiquitin and proteasome pathways
- Pleural and Pulmonary Diseases
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Ultrasound in Clinical Applications
- Advanced MRI Techniques and Applications
- Ectopic Pregnancy Diagnosis and Management
- Abdominal Trauma and Injuries
- Genetics and Neurodevelopmental Disorders
- Pancreatic and Hepatic Oncology Research
- Advanced X-ray and CT Imaging
Duke University
2024
Duke Medical Center
2022-2024
Duke University Health System
2023
Duke University Hospital
2022-2023
University of Massachusetts Chan Medical School
2008-2019
Dartmouth College
2004
The cytoplasmic polyadenylation element binding protein CPEB1 (CPEB) regulates germ cell development, synaptic plasticity, and cellular senescence. A microarray analysis of mRNAs regulated by CPEB unexpectedly showed that several encoded proteins are involved in insulin signaling. An investigation Cpeb1 knockout mice revealed the expression two particular negative regulators action, PTEN Stat3, were aberrantly increased. Insulin signaling to Akt was attenuated livers CPEB–deficient mice,...
Ultrasonography (renamed from the Journal of Korean Society Ultrasound in Medicine January 2014), official English-language journal (KSUM), is an international peer-reviewed academic dedicated to practice, research, technology, and education dealing with medical ultrasound, Aims Scope:Ultrasonography ultrasound.It published four times per year: 1, April July October 1. Original articles, topical reviews, pictorial essays, notable case reports are covering state-of-the-art content. also...
Abstract Purpose: There is a need to identify cancer chemoprevention mechanisms. We reported previously that all-trans-retinoic acid (RA) prevented carcinogenic transformation of BEAS-2B immortalized human bronchial epithelial cells by causing G1 arrest, permitting repair genomic DNA damage. arrest was triggered cyclin D1 proteolysis via ubiquitin-dependent degradation. This study investigated which chemopreventive agents activated this degradation program and whether E also degraded....
Gimap5 (GTPase of the immunity-associated protein 5) has been linked to regulation T cell survival, and polymorphisms in human GIMAP5 gene associate with autoimmune disorders. The BioBreeding diabetes-prone (BBDP) rat a mutation that leads spontaneous apoptosis peripheral cells by an unknown mechanism. Because localizes endoplasmic reticulum (ER), we hypothesized absence functional initiates death through disruptions ER homeostasis. We observed increases stress-associated chaperones but not...
Obesity places major demands on the protein folding capacity of endoplasmic reticulum (ER), resulting in ER stress, a condition that promotes hepatic insulin resistance and steatosis. Here we identify transcription factor, Kruppel-like factor 15 (KLF15), as an essential mediator stress-induced liver. Mice with targeted deletion KLF15 exhibit increased inflammation, JNK activation compared to WT mice; however, KLF15-/- mice are protected against fatty liver under high-fat feeding conditions...
T cell receptor (TCR) ligation (signal one) in the presence of co-stimulation two) results downstream signals that increase protein production enabling naïve cells to fully activate and gain effector function. Enhanced proteins by a requires an endoplasmic reticulum (ER) chaperone expression, which is accomplished through activation cellular mechanism known as ER stress response. The response initiated during cascade events occur for many cells; however, this process has not been...
The centrosome is important for microtubule organization and cell cycle progression in animal cells. Recently, mutations the centrosomal protein, pericentrin, have been linked to human microcephalic osteodysplastic primordial dwarfism (MOPD II), a rare genetic disease characterized by severe growth retardation early onset of type 2 diabetes among other clinical manifestations. While link between defects may account deficiencies, mechanism linking pericentrin with dysregulated glucose...
Background The diagnosis of pulmonary hypertension (PH) remains challenging. Pre- and post-capillary PH have different signatures on noninvasive 129 Xe gas-exchange magnetic resonance imaging (MRI) dynamic MR spectroscopy (MRS). We tested the accuracy MRI/MRS to diagnose status compared right heart catheterisation (RHC). Methods from 93 subjects was used develop a diagnostic algorithm, which in 32 patients undergoing RHC same day (n=20) or within 5 months (42±40 days) (n=12). Three expert...
Pulmonary emphysema is a progressive lung disease that requires accurate evaluation for optimal management. This task, possible using quantitative CT, particularly challenging as scanner and patient attributes change over time, negatively impacting the CT-derived measures. Efforts to minimize such variations have been limited by absence of ground truth in clinical data, thus necessitating reliance on surrogates, which may not one-to-one correspondence CT-based findings. study aimed develop...