A5069893080- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Blood Pressure and Hypertension Studies
- Viral Infections and Immunology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Cardiovascular Health and Disease Prevention
- Hormonal Regulation and Hypertension
- Transplantation: Methods and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Congenital Heart Disease Studies
- Heart Rate Variability and Autonomic Control
- Cardiomyopathy and Myosin Studies
- Sodium Intake and Health
- Pulmonary Hypertension Research and Treatments
- Cardiac Structural Anomalies and Repair
- Renal and Vascular Pathologies
- Inflammatory Myopathies and Dermatomyositis
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular and Diving-Related Complications
- Cardiovascular Issues in Pregnancy
- Whipple's Disease and Interleukins
- Vascular Anomalies and Treatments
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
Federal Almazov North-West Medical Research Centre
2013-2023
Ministry of Health of the Russian Federation
2015-2022
St. Vladimir Children's Moscow Clinical Hospital
2013
Objective. Renal sympathetic denervation (RDN) is one of the invasive treatment options for patients with hypertension (HTN) who are resistant to antihypertensive therapy (AHT). The short-term efficacy RDN has been proven in a number randomized clinical trials, but remains controversial, data on its long-term limited. aim our study was evaluate natural course HTN, assess major adverse cardiovascular events (MACE) and other outcomes, as well AHT features HTN after bilateral during extended...
Background . Congenital heart defects (CHDs) often have genetic background due to missense mutations in cardiomyocyte-specific genes. For example, cardiac actin was shown be involved pathogenesis of septum and smooth muscle aortic aneurysm combination with patent ductus arteriosus (PDA). In the present study, we further searched for human α -cardiac ( ACTC1 ) -actin ACTA2 genes as a possible cause atrial defect type II (ASDII) PDA. Findings Total genomic DNA extracted from peripheral blood...
In a cohort, observational prospective trial, we assessed the long-term dynamics of sleep-disordered breathing in patients with resistant hypertension after renal denervation and their association blood pressure change at remote follow-up.Twenty-eight stable who were recruited for endovascular radiofrequency 2012-2019 had valid both baseline follow-up sleep study, included analysis. All underwent physical examination, anthropometry, office ambulatory measurements, urine tests, kidney...
Aim. To evaluate diagnostic significance of non-invasive methods myocarditis diagnostics. Material and methods. the study, 141 patient included with suspected (104 males, 37 females; age 11-69, mean 42,7±13,7 y. o.). All patients, together clinical assessment, underwent standard echocardiography, magnete resonance tomography (MRI) heart contrast enhancement endomyocardial biopsy histological immunohistochemical analysis. Also, levels circulating cardiotropic autoantibodies, troponin I...
Objective. To investigate the dynamics of renal function in patients with resistant arterial hypertension after denervation depending on degree central and peripheral blood pressure (BP) reduction baseline state kidneys. Design methods. A total 22 (mean age 56,1 ± 10,2 years, 9 males) treated undergoing bilateral (RDN) (Symplicity RDN System, Medtronic, USA) were included. Office BP measuring, 24-hour ambulatory monitoring (ABPM) (SpaceLabs 90207, USA), applanation tonometry (SphygmoCor,...
One of the serious obstacles aortopathies research is a considerable shortage human aortic smooth muscle cells (SMCs), which can be used to model disease. SMC in most cases come from whole aorta transplant donors, are rather difficult access. In course coronary artery bypass graft (CABG) surgery, fragment tissue excised make root. this study, we show possibility use CABG leftover fragments thoracic as source for vitro research. We isolated tissues obtained during procedure and compared these...
Aim: to estimate early and long-term outcomes in recipients under 18 years old who have been heart transplanted Almazov National Medical Research Centre. Materials methods . From April 2011 September 2017 we performed 5 transplantations (HTx) (female) old) from adults donors. The median of age were 15 (range 10–16 years), LVEF prior HTx – 17% (10–33%). Causes failure dilated cardiomyopathy (n = 2), non-compacted myocardium 1), arrhythmogenic ventricular dysplasia 1) Ebstein’s anomaly 1)....
This review focuses on a rare complication of pulmonary arterial hypertension (PAH), extravasation compression the left coronary artery (LCA) dilated by artery. The described clinical manifestations and methods for diagnostics LCA compression, advantages endovascular correction this in patients with hypertension. Selection device to be implanted during intervention these was discussed due account concomitant treatment oral anticoagulants. As an illustration issue under discussion, case acute...
Clinical demonstration of the development acute non-coronarogenic myocardial lesion in a patient with intraoperative rupture arterial aneurysm basilar artery. Neurogenic cardiomyopathy should be considered differential diagnostics heart failure patients cerebral lesion.
to assess clinical and prognostic value of circulating cardiospecific autoantibodies (AAB) CD4+ T-regulatory cells in patients with myocarditis.We included into this study 47 lymphocytic myocarditis verified by analysis histological immunohistochemical data. Comparison group consisted 30 practically healthy persons. Content marker cardiotropic AAT were measured the help standardized immune enzyme test-systems. Number CD4+CD25+ CD4+CD25+FoxP3+ T-lymphocytes evaluated flow cytometry.Among...
Hemoptysis is a rare complication of idiopathic pulmonary arterial hypertension (PAH). A clinical case PAH manifested with recurrent hemoptysis during pregnancy has been described in the paper. Diagnostic approach and optimal management such patients were also discussed. Pulmonary hemorrhage requires active therapeutic interventions including surgical treatment. Endovascular embolization bronchial arteries firstline treatment but this initial detection area interest, intervention volume...
Aim . To estimate the results of 6-year experience heart transplantation (HT) in Federal Almazov North-West Medical Research Centre. Methods. From 2010 to 2015 we have performed 65 HT. Mean age was 44.3 ± 14 years old (from 10 64 old). We used biventricular assist device (BIVAD, Berlin Heart Excor) support 7 transplant candidates before 19 patients (29%) received thymoglobulin, whereas 46 (71%) had basiliximab induce immunosuppression. Results. Extracorporeal membrane oxygenation machines...
During the last two decades, endovascular technology has revolutionized management of patients with abdominal aortic aneurysm (AAA). Today, repair (EVAR) is treatment choice for majority an AAA. Randomized controlled trials provide robust evidence indication AAA and rationale use EVAR in selected patients. However, despite that, practice varies several areas need further elucidation. Important future challenges research include role medical therapy AAA, whether should be any different women...
ТРАНСКАТЕТЕРНАЯ КОРРЕКЦИЯ АНЕВРИЗМЫ И ДВОЙНОГО ВТОРИЧНОГО ДЕФЕКТА МЕЖПРЕДСЕРДНОЙ ПЕРЕГОРОДКИ У ПОЖИЛОГО ПАЦИЕНТА В. Гурьев, Д. А. Зверев Национальный Медицинский Исследовательский Центр им
Objective: Renal denervation (RDN) seems to be safe in patients with true resistant hypertension (RHTN). However long-term effect of significant decrease blood pressure (BP) level on renal function is lacking. We aimed investigate safety the procedure depending degree BP reduction. Design and method: A total 22 (age 56,1 ± 10.2 years, 9 males) RHTN underwent bilateral RDN (Symplicity System, Medtronic, USA). Office BP, ambulatory monitoring, applanation tonometry calculation systolic...
Abstract Background The presence of aortic aneurysm can alters pulse wave propagation and reflection, causing changes in central pressure amplification (PPA) between the aorta brachial artery that might be associated with unfavorable hemodynamic effects for arteries heart. However, impact location increase diameter on blood (CBP) is not fully understood. Objective To investigate PPA regarding to association arterial stiffness patients ascending (AA), descending thoracic abdominal (TAA AAA)....
Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): Grant Russian Foundation for Basic Research Introduction Long existing pressure overload results in left ventricular (LV) hypertrophy severe aortic stenosis (AS). Post-TAVI remodeling after relief the high-pressure could lead to manifestation postprocedural midventricular obstruction caused mostly by marked LV wall with interposition hypertrophic papillary muscle small chamber. Our aim was evaluate...
Objective: Renal denervation results in reduction of local and overall noradrenaline spillover, which may lead to alteration different parameters associated with excess sympathetic activity. Obesity is closely linked increased tone we assessed the change circulating adipokines levels their relation vascular reactivity stiffness after renal patients true resistant hypertension (RHTN) during one year follow-up. Design method: (Ardian, Medtronic) was performed according standard protocol 20 (8...