Purpose Blood pressure telemonitoring and remote counselling (BPTM) improves blood (BP) control in patients with hypertension (HTN). Studies assessing the efficacy of BPTM from a value-based perspective are lacking. We investigated whether fits all principles approach (clinical economic effectiveness, improvement patient-reported outcome/experience measures (PROM/PREM)).Materials methods Two hundred forty ambulatory uncontrolled HTN were randomised 2: 1 manner to (n = 160, mean age 47 y.o.)...

Objective. To evaluate patient-oriented endpoints and antihypertensive effectiveness of blood pressure (BP) monitoring distant counseling (TMDC) among outpatients with uncontrolled hypertension (HTN). Design methods . Programs TMDC different duration follow-up (1, 3, 6, 12 months) were developed (with obligatory initial final clinic visits). The demand in was assessed by a preliminary survey cardiologists (n = 73) hypertensive patients 540) referred to Almazov National Medical Research...

Objective. Renal sympathetic denervation (RDN) is one of the invasive treatment options for patients with hypertension (HTN) who are resistant to antihypertensive therapy (AHT). The short-term efficacy RDN has been proven in a number randomized clinical trials, but remains controversial, data on its long-term limited. aim our study was evaluate natural course HTN, assess major adverse cardiovascular events (MACE) and other outcomes, as well AHT features HTN after bilateral during extended...

XXI century emphasized humanity to embrace the digital era after a reality of Third and Fourth Industrial Revolutions, nowadays dictating new terms social networking. It is expected that information communication technologies integrated with value-based medicine will significantly impact healthcare delivery tremendous number patients socially important noncommunicable diseases. Cardiovascular illnesses comprise greatest part such pathologies. Hypertension (HTN) being most prevalent...

Aim. To investigate the baseline characteristics of patients with resistant hypertension (HTN) undergoing radiofrequency renal sympathetic denervation (RD) and to determine immediate procedural effects. Material methods . During 2018-2019, two series RD procedures were performed in true HTN using balloon-type (bipolar ablation) or spiral-type (unipolar multielectorde catheters. The basic demographic, clinical laboratory included assessed. A comparative analysis groups was carried out...

Aim. To compare the relationships between conventional and new potentially more early investigational biomarkers (urine ultrasound) of kidney injury central aortic blood pressure, vascular stiffness reactivity, endothelial dysfunction in patients with different severity hypertension. Material methods. Urine levels NGAL, KIM-1, L-FABP, albuminuria serum сystatin C creatinine were measured 92 hypertensive mild severe hypertension, 46 male (mean age 50,7±12,2 years). Glomerular filtration rate...

Objective . To describe the technical issues and safety of renal denervation (RD) when using a multielectrode radiofrequency (RF) bipolar balloon catheter, unipolar RF spiral an electrophysiological (EP) 3,5-mm ablation catheter. Design methods Between 2016 2019, 54 patients undergoing artery (RA) were included into prospective observational study: 27 procedures performed technology, 21 — spiral; 6 steerable irrigated EP catheter under three-dimensional electroanatomical guidance. In 50 RD...

In a cohort, observational prospective trial, we assessed the long-term dynamics of sleep-disordered breathing in patients with resistant hypertension after renal denervation and their association blood pressure change at remote follow-up.Twenty-eight stable who were recruited for endovascular radiofrequency 2012-2019 had valid both baseline follow-up sleep study, included analysis. All underwent physical examination, anthropometry, office ambulatory measurements, urine tests, kidney...

Objective. The aim of the present study was to compare conventional and novel, potentially earlier biomarkers kidney injury in patients with different severity duration arterial hypertension (HTN) healthy controls. Design methods. Urine levels neutrophil gelatinase-associated lipocalin (NGAL), molecule‑1 (KIM‑1), liver fatty-acid binding protein (L‑FABP), albuminuria serum cystatin C creatinine were measured 92 hypertensive (46 male, mean age 50,7 ± 12,2 years) 34 control subjects (16 49,9...

Objective. To investigate the dynamics of renal function in patients with resistant arterial hypertension after denervation depending on degree central and peripheral blood pressure (BP) reduction baseline state kidneys. Design methods. A total 22 (mean age 56,1 ± 10,2 years, 9 males) treated undergoing bilateral (RDN) (Symplicity RDN System, Medtronic, USA) were included. Office BP measuring, 24-hour ambulatory monitoring (ABPM) (SpaceLabs 90207, USA), applanation tonometry (SphygmoCor,...

Objective. To assess the etiology of drug-resistant hypertension in patients with combination therapy. Design and methods. Out-patient subjects (n = 336, 94 males 242 females, mean age — 54 ± 3 years) were followed up for one year (every 2-4 weeks during first three months, then every 3-6 months till follow-up). Examination included assessment cortisol aldosterone levels, renin activity, duplex scan renal arteries, sleep study. Results. Secondary was verified 29 (8,6 %) patients: primary...

Subject. This article discusses the issues of managing complex systems and feedback quality. Objectives. The aims to develop a process model for functioning regional public administration system. Methods. For study, we used analysis. Results. presents design single control loop based on goal-oriented system an automatic offers complete lists elements projects Conclusions. Further development implementation proposed project management can help improve effectiveness targeted activities.

Subject. This article discusses the issues of legal groundwork for reforms in energy area. Objectives. The aims to analyze statutory standards and regulations governing use renewable sources. Methods. For study, we used general scientific research methods. Results. Using wind development case, shows that management system field sources is characterized by internal contradictions. Conclusions. To develop new areas sector, it necessary design an integral regulation related strategic planning documents.

Objective: To assess the dynamics of arterial stiffness and central blood pressure (CBP) investigate factors affecting them in thoracic abdominal aortic aneurysms patients with hypertension one year after [thoracic] endovascular aneurysm repair ([T]EVAR). Design method: Patients older 18 y.o. without clinically significant arrhythmias were included. Before [T]EVAR a later, following examination was performed: measurement peripheral CBP, heart rate (HR), augmentation index (AIx), pulse height...

Objective: To determine the frequency and severity of orthostatic responses central peripheral blood pressure (BP) during Active Stand Test (AST) in patients with arterial hypertension (HTN) hemodynamically significant stenosis internal carotid artery (ICA). Design method: The intervention group included aged 18 years older HTN ICA >50% (NASCET) atherosclerotic origin. Patients without lesions were considered as controls. In all AST was performed measurement BP sitting standing positions...

Objective: To assess the pulse wave velocity (PWV) and orthostatic changes of peripheral (brachial) central blood pressure (P/CBP) in patients with ascending aortic aneurysm (AAA) thoracoabdominal AA (TAAA). Design method: A total 79 AAA (n =41, 28 males; 54±13 y.o.) TAAA =38; 33 68±8 were examined prior to surgical treatment. Brachial BP, CBP PWV measured supine position after 10 min rest then 5 active standing using OMRON M3 EXPERT (Japan) SphygmoCor (Australia). Ambulatory BP monitoring...

Aim . To analyze perioperative characteristics, including central hemodynamic parameters, of patients with hypertension (HTN) and descending thoracic aortic aneurysm (TAA) or abdominal (AAA) who were referred for endovascular repair ([T]EVAR). Material methods Local registry data used. The study included 126 (103 men, 67±9 years). In addition to the basic examination, noninvasive measurement blood pressure (BP) carotid-femoral pulse wave velocity (cfPWV) was performed. Quality life (QOL)...

In 2018, at the annual congresses of European Society Hypertension and Cardiology, updated guidelines on diagnostics, management prevention arterial hypertension were announced, followed by their publication in Heart Journal. The present a comprehensive overview definition classification hypertension, approaches to blood pressure measurement, assessment target organ damage, special patient subgroups other issues. Despite detailed analysis various issues diagnostics treatment some statements...

Aortic aneurysm (AA) is one of the most formidable cardiovascular diseases, characterized by subtle clinical manifestations and a high risk complications. Predisposing factors in development AA are age, arterial hypertension (HTN), atherosclerosis, inflammatory aortic diseases. Those associated with changes vascular stiffness. HTN causes increased tension wall when pulse wave blood pressure (BP) rises patients AA. Indicators central BP stiffness particular interest. They present as...

Aim . To assess the changes of arterial stiffness, central blood pressure (CBP), and determine factors potentially influencing them in patients with descending thoracic abdominal aortic aneurysm, combination hypertension, one year after endovascular aneurysm repair ((T)EVAR). Material methods Patients ≥18 years age without clinically significant cardiac arrhythmias were included. Before surgery a later, we determined peripheral pressure, heart rate (HR), CBP, augmentation index (AIx), at...

Background : Arterial hypertension (HTN) remains a key risk factor for cardiovascular disease burden and mortality. Efficacy of treatment differs across regions, depending on various medical facilities. Assessment specific features antihypertensive (AHT) provided in cardiology outpatient care setting is special interest. Objective To investigate comorbidity factors to determine the patients with HTN referred federal center. Design methods Retrospective analysis was conducted using 100...

The review discusses the new data about primary aldosteronism and connection between increase of aldosterone level resistance to antihypertensive treatment, including patients with obstructive sleep apnea. Also main pathophysiological mechanisms underlying progression end organ damage leading treatment in high are presented.