The purpose of this study was to evaluate the efficacy and toxicity an intensified dose protocol with no maintenance phase for treatment canine lymphoma. Forty-nine dogs all weighing more than 15 kg were entered. Dogs staged treated a modified version University Wisconsin (UW)-Madison Modifications included increased dosages cyclophosphamide (250 mg/m2 compared 200 mg/m2) doxorubicin (37.5 30 mg/m2), crossover chlorambucil or methotrexate. After 25 weeks on (17 treatments), therapy...

The purpose of this study was to compare a maintenance‐free chemotherapy protocol based on CHOP (H from hydroxydaunorubicin = doxorubicin, O Oncovin®= vincristine) similar with maintenance phase for the treatment canine lymphoma. Fifty‐three dogs multicentric lymphoma were treated 6‐month modified version University Wisconsin (UW)‐Madison (UW‐25). Disease‐free interval (DFI) and survival compared historical control group 55 prolonged phase. Remission rate 94.2% (complete remission 92.3%,...

All companion animal practices will be presented with oncology cases on a regular basis, making diagnosis and treatment of cancer an essential part comprehensive primary care. Because each case is medically unique, these guidelines recommend patient-specific approach consisting the following components: diagnosis, staging, therapeutic intervention, provisions for patient personnel safety in handling chemotherapy agents, referral to specialty practice when appropriate, strong emphasis client...

To compare the detection of pulmonary nodules by use 3-view thoracic radiography and CT in dogs with confirmed neoplasia.Prospective case series.33 various breeds.3 interpreters independently evaluated images. The location size were recorded. Computed tomographic scans thorax obtained a single interpreter. location, size, margin, internal architecture, density Sensitivity, specificity, positive predictive value, negative value calculated for (with as gold standard).21 33 (64%) had or masses...

CHOP-based (cyclophosphamide, doxorubicin, vinca alkaloid, prednisolone) chemotherapy protocols are often recommended for treatment of feline lymphoma. While maintenance-free have been published and readily used in dogs, there is limited literature regarding similar cats. The purpose this study was to describe the outcome cats with intermediate- high-grade lymphoma that were prescribed a modified 25-week University Wisconsin-Madison (UW-25) protocol. A secondary objective examination...

To describe clinical outcome of dogs with mast cell tumors (MCTs) arising from the oral mucosa, mucocutaneous junction, or perioral region muzzle and evaluate potential role chemokine receptor type 7 (CCR7) in biological behavior these tumors.Retrospective case series.44 MCTs mucosa (n=14), junction (19), (11).Medical records were reviewed for information on signalment, regional metastasis, treatments, cause death, survival time. Twenty 44 cases had stored histologic samples available...

Abstract Melanoma is the most common oral malignancy in dogs. This retrospective study evaluated adjuvant carboplatin chemotherapy (with or without radiation therapy) 17 dogs with malignant melanoma following surgical resection. The median dosage and number of doses administered to was 300 mg m −2 (range, 150–300 ) 4 2–11), respectively. overall progression‐free survival for all 259 days [95% confidence interval ( CI 95 ), 119–399 days]. first event local recurrence seven (41%) metastases...

The purpose of this study was to evaluate the efficacy and toxicity an intensified dose protocol with no maintenance phase for treatment canine lymphoma. Forty‐nine dogs all weighing more than 15 kg were entered. Dogs staged treated a modified version University Wisconsin (UW)‐Madison Modifications included increased dosages cyclophosphamide (250 mg/m 2 compared 200 ) doxorubicin (37.5 30 ), crossover chlorambucil or methotrexate. After 25 weeks on (17 treatments), therapy discontinued...

Canine osteosarcoma (OSA) causes focal malignant osteolysis leading to severe pain. Despite the documented efficacy of radiotherapy or IV aminobisphosphonates for managing cancer bone pain, their potential combined therapeutic value has not been reported in OSA-bearing dogs.Pamidronate with standardized palliative therapy will improve pain control and biologic effects dogs.Fifty dogs appendicular OSA treated either pamidronate sterile saline.Randomized, prospective, double-blinded,...

Spenic hemangiosarcoma (HSA) in dogs treated with surgery alone is associated short survival times, and the addition of doxorubicin (DOX) chemotherapy only modestly improves outcome. The purpose this study was to evaluate impact toceranib administration on progression free stage I or II HSA following splenectomy single agent DOX chemotherapy. We hypothesized that splenic adjuvant followed by would have prolonged disease-free interval (DFI) overall time (OS) when compared historical DOX-based...

Thirty-five dogs with appendicular osteosarcoma underwent amputation and chemotherapy cisplatin doxorubicin every 21 days for up to four cycles. Sixteen completed all Two had therapy discontinued because of metastases. The remaining 17 experienced toxicities necessitating protocol alteration or discontinuation. median survival time 300 was not improved over previously reported single-agent protocols, but the 10 that survived a year lived 510 days.

Malignant osteolysis is a process whereby cancer cells in concert with osteoclasts erode bone matrix. Aminobisphosphonates (NBPs) such as zoledronate induce osteoclast apoptosis and thereby decrease malignant skeletal destruction, severity of pain, frequency pathologic fracture.IV-administered will reduce homeostatic turnover healthy dogs resorption diagnosed primary secondary tumors.Six 20 naturally occurring or metastatic tumors were administered IV.Prospective study: In all dogs, (n = 6)...

Abstract Objective —To evaluate the veterinary version of bladder tumor antigen (V-BTA) test as a screening for transitional cell carcinoma (TCC) lower urinary tract dogs. Animals —229 client-owned Procedure —Urine samples from dogs were shipped overnight to single laboratory facilitate testing within 48 hours collection by use V-BTA rapid latex agglutination urine dipstick test. Groups included following: 1) with TCC tract, 2) healthy control dogs, 3) unhealthy non-TCC disease, and 4)...

The purpose of this study was to compare a maintenance-free chemotherapy protocol based on CHOP (H from hydroxydaunorubicin = doxorubicin, O Oncovin vincristine) similar with maintenance phase for the treatment canine lymphoma. Fifty-three dogs multicentric lymphoma were treated 6-month modified version University Wisconsin (UW)-Madison (UW-25). Disease-free interval (DFI) and survival compared historical control group 55 prolonged phase. Remission rate 94.2% (complete remission 92.3%,...

The purpose of this retrospective study was to describe the biological behaviour canine mandibular osteosarcoma (OSA) and examine factors for their impact on metastasis-free interval (MFI) survival time (ST). Records from dogs treated with mandibulectomy OSA (1999-2007) were reviewed. Archived tumour samples evaluated mitotic index (MI) grade. Fifty included, 21 received chemotherapy. Twenty-nine (58%) developed metastatic disease. median MFI 627 days, ST 525 days. In univariate analysis MI...

Objective To report demographic characteristics of a contemporary population dogs with appendicular osteosarcoma and assess the relationship between characteristics, site distribution, phylogenetic breed clusters. Design Retrospective case series. Methods A search Veterinary Medical Database was performed for as new diagnosis. Entries were reviewed sex, neuter status, age at diagnosis, breed, affected limb, tumor location. The reported purebred used to categorize each dog into one five...

The objective of this retrospective study was to evaluate hyperthyroid cats for pretreatment factors that would predict response radioiodine therapy. Hyperthyroidism diagnosed in 193 based on elevated serum thyroxine levels and/or thyroid salivary gland ratios scintigraphy. All were treated with an intravenous bolus 4 mCi and follow-up evaluated at 1 week 1, 3, 6, 12 months post-therapy. There a significant relationship between values post-treatment all the time points (p < 0.001). also...

To evaluate factors associated with second remission in dogs lymphoma retreated a cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) protocol after relapse following initial treatment first-line 6-month CHOP protocol.Retrospective case series.95 lymphoma.Medical records were reviewed. Remission duration was estimated by use of the Kaplan-Meier method. Factors potentially prognosis examined.Median 289 days (range, 150 to 1,457 days). Overall, 78% (95% confidence interval [CI],...

In dogs with appendicular osteosarcoma (OSA), increased pretreatment serum bone-specific alkaline phosphatase (BALP) activity is a negative prognostic factor, associated shorter disease-free intervals and survival times, but biologic basis for observed differential BALP activities in canine OSA patients remains incompletely defined.Serum will correlate absolute tumor burden OSA.This study included 96 client-owned OSA.In cell lines, the expression membranous release of was evaluated vitro....