A5034031384- Mathematical and Theoretical Epidemiology and Ecology Models
- HIV Research and Treatment
- COVID-19 epidemiological studies
- HIV/AIDS Research and Interventions
- Evolution and Genetic Dynamics
- Hepatitis C virus research
- Immune Cell Function and Interaction
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Neural Networks Stability and Synchronization
- COVID-19 Pandemic Impacts
- Influenza Virus Research Studies
- Evolutionary Game Theory and Cooperation
- Cervical Cancer and HPV Research
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Advanced Memory and Neural Computing
- Nonlinear Dynamics and Pattern Formation
- Mathematical Biology Tumor Growth
- Neural Networks and Applications
- stochastic dynamics and bifurcation
- Animal Virus Infections Studies
- Infection Control and Ventilation
- Animal Disease Management and Epidemiology
University of Florida
2017-2024
Shanghai Maritime University
2022
Hangzhou Normal University
2022
Shaanxi Normal University
2020-2021
Florida State University
2021
Florida College
2021
Xinyang Normal University
2019
Oakland University
2010-2017
Henan University
2017
York University
2017
Computational modeling suggests that the rapid emergence of resistance to drugs against hepatitis C virus is a result preexisting resistant and potent suppression wild-type virus.
The nonstructural 5A (NS5A) protein is a target for drug development against hepatitis C virus (HCV). Interestingly, the NS5A inhibitor daclatasvir (BMS-790052) caused decrease in serum HCV RNA levels by about two orders of magnitude within 6 h administration. However, has no known enzymatic functions, making it difficult to understand daclatasvir's mode action (MOA) and estimate its antiviral effectiveness. Modeling viral kinetics during therapy provided important insights into MOA...
Influenza virus infection remains a public health problem worldwide. The mechanisms underlying viral control during an uncomplicated influenza are not fully understood. Here, we developed mathematical model including both innate and adaptive immune responses to study the within-host dynamics of equine in horses. By comparing modeling predictions with interferon kinetic data, examined relative roles target cell availability, controlling virus. Our results show that rapid substantial decline...
<abstract> <p>The novel Coronavirus (COVID-19) is spreading and has caused a large-scale infection in China since December 2019. This led to significant impact on the lives economy other countries. Here we develop discrete-time stochastic epidemic model with binomial distributions study transmission of disease. Model parameters are estimated basis fitting newly reported data from January 11 February 13, 2020 China. The estimates contact rate effective reproductive number support...
Although potent combination therapy is usually able to suppress plasma viral loads in HIV-1 patients below the detection limit of conventional clinical assays, a low level viremia frequently can be detected by more sensitive assays. Additionally, many experience transient episodes above limit, termed blips, even after being on highly suppressive for years. An obstacle eradication persistence latent reservoir resting memory CD4(+) T cells. The mechanisms underlying load persistence, slow...
Various classes of antiretroviral drugs are used to treat HIV infection, and they target different stages the viral life cycle. Age‐structured models can be employed study impact these on dynamics. We consider two with age‐of‐infection combination therapies involving reverse transcriptase, protease, entry/fusion inhibitors. The reproductive number ${\cal R}$ is obtained, a detailed stability analysis provided for each model. Interestingly, we find in age‐structured model functional...
Hubei province in China has completed cycle of quarantine-resumption 23rd Janauary and 8th April 2020, providing a unique opportunity as for now to assess its intervention impact the pattern SARS-COV-2 transmission during quarantine period. In this study, we evaluate metropolitan-wide on trend route COVID-19 epidemic Hubei, China. The reduces more than 70% new infections both households public space, well deaths caused by pneumonia. Household is dominant disease spread regardless quarantine....
Multiple candidates of COVID-19 vaccines have entered Phase III clinical trials in the United States (US). There is growing optimism that social distancing restrictions and face mask requirements could be eased with widespread vaccine adoption soon.We developed a dynamic compartmental model transmission for four most severely affected states (New York, Texas, Florida, California). We evaluated effectiveness coverage required to suppress epidemic scenarios when contact was return pre-pandemic...
HIV can infect cells via virus-to-cell infection or cell-to-cell viral transmission. These two modes may occur in a synergistic way and facilitate spread within an infected individual. In this paper, we developed latent model including both of transmission time delays between entry integration production. We analysed the by defining basic reproductive number, showing existence, positivity boundedness solution, proving local global stability infection-free steady states. Numerical simulations...
The current paradigm for studying hepatitis C virus (HCV) dynamics in patients utilizes a standard viral dynamic model that keeps track of uninfected (target) cells, infected and virus. does not account the intracellular replication, which is major target direct-acting antiviral agents (DAAs). Here we describe study recently developed multiscale age-structured explicitly considers potential effects DAAs on RNA production, degradation, secretion as into circulation. We show when therapy...
Emergence of resistance is a major concern in influenza antiviral treatment and prophylaxis. Combination therapy might overcome this problem. Here, we estimate that all possible single mutants sizeable fraction double are generated during an uncomplicated infection. While most them may sustain fitness cost, some variants confer drug be selected therapy. We argue triple combination regimen would markedly reduce the risk emergence seasonal pandemic viruses, especially seriously ill or...