A5012406728- Click Chemistry and Applications
- Natural product bioactivities and synthesis
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Essential Oils and Antimicrobial Activity
- Sphingolipid Metabolism and Signaling
- Lipid metabolism and biosynthesis
- Bee Products Chemical Analysis
- Hormonal and reproductive studies
- Inflammasome and immune disorders
- Bioactive Compounds and Antitumor Agents
- Pesticide Residue Analysis and Safety
- Plant biochemistry and biosynthesis
- Zebrafish Biomedical Research Applications
- Adipokines, Inflammation, and Metabolic Diseases
- RNA Interference and Gene Delivery
- Metabolomics and Mass Spectrometry Studies
- Insect and Pesticide Research
- Herbal Medicine Research Studies
- Extracellular vesicles in disease
- Systemic Lupus Erythematosus Research
- Retinoids in leukemia and cellular processes
- Rheumatoid Arthritis Research and Therapies
Université de Moncton
2009-2024
Alkyne and azide analogs of natural compounds that can be coupled to sensitive tags by click chemistry are powerful tools study biological processes. Arachidonic acid (AA) is a FA precursor biologically active compounds. 19-Alkyne-AA (AA-alk) clickable AA analog; however, its use as surrogate metabolism requires further evaluation. In this study, AA-alk was compared with in human cells. Jurkat cell uptake 2-fold greater than AA-alk, but significantly more AA-Alk elongated 22:4. incorporation...
Soxhlet (SE), microwave-assisted (MAE) and ultrasound-assisted (UAE) extraction were compared using ten solvents for their efficiency to extract phenolic flavonoid antioxidants from Eastern Canada propolis. Extracts total (TPC) (TFC) content, radical scavenging activities. Anti-inflammatory activity through inhibition of 5-lipoxygenase (5-LO) products biosynthesis in HEK293 cells was also evaluated. The results showed that SE extracts polar had the highest TPC TFC. obtained with ethanol,...
Abstract 5‐lipoxygenase (5‐LO) catalyzes the biosynthesis of leukotrienes, potent lipid mediators involved in inflammatory diseases, and both 5‐LO leukotrienes are validated therapeutic targets. Caffeic acid phenethyl ester (CAPE) is an effective inhibitor leukotriene but susceptible to hydrolysis by esterases. In this study a number CAPE analogues were synthesized with modifications caffeoyl moiety replacement linkage ketone. Several new molecules showed better inhibition than isolated...
The syntheses of twelve caffeoyl/cinnamoyl clusters and their anti-inflammatory anti-cancer effects are described. Synthesis the title compounds involved a multiple copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition. Azide or alkyne functionalized cinnamoyl caffeoyl moieties attached to selected core molecules allow variation introduced in order compare on 5-lipoxygenase (5-LO) inhibition cell proliferation cancerous (MCF7) non (MCF10A) human mammary epithelial lines. Caffeoyl dimer 13,...
Objective Mouse models are valuable in preclinical studies of inflammatory arthritis. However, current methods for measuring disease severity or responses to treatment not optimal. In this study a smart cage system using multiple sensors measure locomotor activity was evaluated the K/BxN serum transfer model Methods Arthritis induced C57BL/6 mice with injections serum. Clinical index and ankle thickness were measured 14 days. Locomotor cages 23 h periods on Days 0, 7, 13. The same...
The inflammatory response is an essential process for the host defence against pathogens. Lipid mediators are important in coordinating pro-inflammatory and pro-resolution phases of process. However, unregulated production these has been associated with chronic diseases such as arthritis, asthma, cardiovascular diseases, several types cancer. Therefore, it not surprising that enzymes implicated lipid have targeted potential therapeutic approaches. Amongst molecules,...