A5073346002- Photochemistry and Electron Transfer Studies
- Protein Structure and Dynamics
- Music and Audio Processing
- RNA and protein synthesis mechanisms
- Molecular spectroscopy and chirality
- Free Radicals and Antioxidants
- Crystallization and Solubility Studies
- Radical Photochemical Reactions
- Neuroscience and Music Perception
- Origins and Evolution of Life
- Music Technology and Sound Studies
- Enzyme Structure and Function
- Diverse Musicological Studies
- Crystallography and molecular interactions
- History and advancements in chemistry
- Chemistry and Stereochemistry Studies
- Spectroscopy and Quantum Chemical Studies
- Various Chemistry Research Topics
- Photochromic and Fluorescence Chemistry
- Photoreceptor and optogenetics research
- Porphyrin and Phthalocyanine Chemistry
- Inorganic and Organometallic Chemistry
- Electron Spin Resonance Studies
- Advanced Chemical Physics Studies
- Organic Chemistry Cycloaddition Reactions
Institute for Basic Science
2019-2025
University of Manchester
2017-2018
Yale University
2000-2017
University of New Haven
2016
Roskilde University
1999
Met Office
1999
University of Leeds
1999
University of Copenhagen
1999
University of Reading
1999
National Oceanography Centre
1999
AlphaFold2 (AF) is a promising tool, but it accurate enough to predict single mutation effects? Here, we report that the localized structural deformation between protein pairs differing by only 1-3 mutations-as measured effective strain-is correlated across 3901 experimental and AF-predicted structures. Furthermore, analysis of ∼11 000 proteins shows local change correlates with various phenotypic changes. These findings suggest AF can range magnitude single-mutation effects on average,...
Both music and language are found in all known human societies, yet no studies have compared similarities differences between song, speech, instrumental on a global scale. In this Registered Report, we analyzed two datasets: (i) 300 annotated audio recordings representing matched sets of traditional songs, recited lyrics, conversational melodies from our 75 coauthors speaking 55 languages; (ii) 418 previously published adult-directed song speech 209 individuals 16 languages. Of six...
New insights into the mechanism of crystal nucleation emerge from a study by Kondepudi et al., on crystallization NaClO 3 stirred solution. Rectangular prisms chiral space group P 2 1 precipitate aqueous solutions achiral ions. If solution is not stirred, crystals both enantiomorphic forms in equal amounts—exactly as was reported almost one hundred years ago. However, when then exclusively only right‐handed or left‐handed are formed. There simple explanation for this extremely surprising and...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUnsubstituted cyclopentadienyl cation, a ground-state tripletM. Saunders, R. Berger, A. Jaffe, J. M. McBride, O'Neill, Breslow, Hoffmann, C. Perchonock, E. Wasserman, and . et al.Cite this: Am. Chem. Soc. 1973, 95, 9, 3017–3018Publication Date (Print):May 1, 1973Publication History Published online1 May 2002Published inissue 1 1973https://pubs.acs.org/doi/10.1021/ja00790a049https://doi.org/10.1021/ja00790a049research-articleACS PublicationsRequest...
Change of heart: A solution-phase enantiomeric excess that has the handedness minor population solid phase is observed during grinding a slurry racemic conglomerate crystals. This driving force for net flux molecules from crystals to major handedness, thus explaining complete deracemization (see picture: blue: S form, red: R form).
ADVERTISEMENT RETURN TO ISSUEPREVArticleThe role of local stress in solid-state radical reactionsJ. Michael McBrideCite this: Acc. Chem. Res. 1983, 16, 8, 304–312Publication Date (Print):August 1, 1983Publication History Published online1 May 2002Published inissue 1 August 1983https://pubs.acs.org/doi/10.1021/ar00092a007https://doi.org/10.1021/ar00092a007research-articleACS PublicationsRequest reuse permissionsArticle Views284Altmetric-Citations106LEARN ABOUT THESE METRICSArticle Views are...
Beim Mahlen einer Aufschlämmung eines kristallinen racemischen Konglomerats beobachtet man einen Enantiomerenüberschuss in der Lösungsphase, die Händigkeit Minderpopulation den Festkörpern aufweist. Dieser Überschuss ist treibende Kraft für Netto-Molekülfluss von Kristallen hin zu denen Hauptpopulation, was vollständige Deracemisierung Festphase erklärt (siehe Bild; blau: S-Form, rot: R-Form). Detailed facts of importance to specialist readers are published as "Supporting Information". Such...
Organic single crystals provide an ideal model for studying the factors that influence chemical processes in structured media. Reaction trajectories are well defined and reveal of spontaneous mechanical stresses equivalent to tens thousands atmospheres. Analysis molecular crystal structures helps explain both local properties, which reactions, bulk properties such as melting point, compressibility, surface energy.
Let's get together: Racemic samples of d- and l-enantiomorphous NaBrO3 (or NaClO3) crystals aggregate with nearly complete enantioselection. Centimeter-sized enantiopure megacrystals are often produced, these can be sorted easily.
Abstract The optical symmetry of many crystals is lower than would be expected from their external form and X‐ray diffraction data. Recently such anomalies have been attributed to nonequilibrium structures resulting kinetically controlled crystal growth. Impurities are incorporated different extents at various surface sites that otherwise become symmetry‐related within the bulk crystal. After discovery by Brewster in 1815, optically anomalous were subject lively debate throughout 19th...
Standardized cross-cultural databases of the arts are critical to a balanced scientific understanding performing arts, and their role in other domains human society. This paper introduces Global Jukebox as resource for comparative study culture. The adds an extensive detailed global database that enlarges our cultural diversity. Initially prototyped by Alan Lomax 1980s, its core is Cantometrics dataset, encompassing standardized codings on 37 aspects musical style 5,776 traditional songs...
Abstract Proteins are intricate molecular machines whose complexity arises from the heterogeneity of amino acid building blocks and their dynamic network many-body interactions. These nanomachines gain function when put in context a whole organism through interaction with other inhabitants biological realm. And this functionality shapes evolutionary histories intertwined paths selection adaptation. Recent advances machine learning have solved decades-old problem how protein sequence...
AI algorithms have proven to be excellent predictors of protein structure, but whether and how much these can capture the underlying physics remains an open question. Here, we aim test this question using Alphafold2 (AF) algorithm: We use AF predict subtle structural deformation induced by single mutations, quantified strain, compare with experimental datasets corresponding perturbations in folding free energy $\mathrm{\ensuremath{\Delta}}\mathrm{\ensuremath{\Delta}}G$. Unexpectedly, find...
The theory of Jesse Berezovsky (2019) is a rare foray physicist into the territory music science. In their follow-up article in Empirical Musicology Review, Ryan Buechele, Alex Cooke, and (2024) show how evolution Western tuning systems compositions can be rationalized by theoretical model that describes trade-off between minimizing sensory dissonance maximizing compositional variety. From Renaissance period onwards there was trend towards more dissonance, variety both compositions. While...
The evolution of music, speech, and sociality have been debated since before Darwin. social bonding hypothesis proposes that these phenomena may be interlinked: musicality facilitated the beyond possibilities spoken language. Although dozens experimental studies argued synchronised rhythms can promote bonding, methodological issues including publication bias, sample experimenter effects, appropriateness controls make it unclear whether synchronous singing reliably generally enhances relative...
The evolution of music, speech, and sociality have been debated since before Darwin. social bonding hypothesis proposes that these phenomena may be interlinked: musicality facilitated the beyond possibilities spoken language. Although dozens experimental studies argued synchronised rhythms can promote bonding, methodological issues including publication bias, sample experimenter effects, appropriateness controls make it unclear whether synchronous singing reliably generally enhances relative...
ABSTRACT The many seepage meter designs presented to date are generally fragile and require direct installation by divers. On large surface‐water bodies, such as the Great Lakes, storm wave size, water depth, temperature, turbidity make these previous meters ineffective. A design is in this paper which heavy sturdy enough withstand Lakes storms can be remotely installed from surface. These UWM stabilization on bottom of 15 25 minutes before activation must corrected for slow settling...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTX-ray and electron paramagnetic resonance structural investigation of oxygen discrimination during the collapse methyl-benzoyloxy radical pairs in crystalline acetyl benzoyl peroxideNathan J. Karch, Edward T. Koh, Bonnie L. Whitsel, Michael McBrideCite this: Am. Chem. Soc. 1975, 97, 23, 6729–6743Publication Date (Print):November 1, 1975Publication History Published online1 May 2002Published inissue 1 November...
This way or that: Analysis of the chiral composition crystal mixture obtained from samples boiling solutions NaClO3 (see picture) indicates that symmetry breaking towards homochiral compositions may begin in metastable stage preceding crystallization, is, at level subcritical clusters.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2-Isopropylidenecyclopentane-1,3-diyl. Preparation, properties, and reactions of a distorted trimethylenemethane. Direct evidence for triplet reactionJerome A. Berson, Richard J. Bushby, Michael McBride, TremellingCite this: Am. Chem. Soc. 1971, 93, 6, 1544–1546Publication Date (Print):March 1, 1971Publication History Published online1 May 2002Published inissue 1 March...
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Further Study of the exo- and endo-2-Carbo-t-butylperoxynorbornanesPaul D. Bartlett J. Michael McBrideCite this: Am. Chem. Soc. 1965, 87, 8, 1727–1733Publication Date (Print):April 1, 1965Publication History Published online1 May 2002Published inissue 1 April 1965https://pubs.acs.org/doi/10.1021/ja01086a020https://doi.org/10.1021/ja01086a020research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations41LEARN ABOUT...