A5047792385- Cancer-related molecular mechanisms research
- Asthma and respiratory diseases
- Chemokine receptors and signaling
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- 14-3-3 protein interactions
- Cell death mechanisms and regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Viral-associated cancers and disorders
- Inflammatory mediators and NSAID effects
- Chronic Lymphocytic Leukemia Research
- Renal Diseases and Glomerulopathies
- Circular RNAs in diseases
Taizhou Central Hospital
2017-2022
Taizhou University
2020-2022
Papillary thyroid carcinoma (PTC) is the most common endocrine system malignant cancer, and patients with lymph node metastasis typically exhibit poor prognosis. MicroRNAs (miRNAs) can act as either oncogenes or tumor suppressors in PTC. This study was aimed at using PTC transcriptome data obtained from The Cancer Genome Atlas (TCGA) to identify differentially expressed, survival-related miRNAs target genes.We analyzed TCGA datasets expressed mRNAs/miRNAs 493 stage I_II group (stages I II)...
Essential thrombocythaemia (ET) and Waldenström macroglobulinaemia (WM) are two distinct disorders. Studies have reported several cases of myeloproliferative neoplasms (MPNs) with concomitant plasma cell dyscrasia. However, there were no ET WM to date. Here, we present a 55-year-old Chinese man thrombocytosis raised immunoglobulin level. Further investigations led diagnosis coexistent WM. Next-generation sequencing (NGS) his bone marrow identified 3 mutated genes: JAK2 V617F, MYD88 L265P,...
Objective To investigate the potential roles of tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)signaling system in pathogenesis colorectal cancer. Methods Immunohistochemistry techniques were used,the TRAIL and its receptor(TRAILR3,TRAILR4)protein analyzed both 41 cancer samples(colorectal group)and normal samples beside tissue(normal group). Results The levels TRAILR3 protein expression group significantly lower than those...
Objective To investigate the potential roles of nucleotide-binding oligomerization domain(NOD)-like receptor in pathogenesis asthma. Methods Through rat asthma model, 24 rats were randomly divided into three groups on average, named group, control group and dexamethasone group.Expression levels NOD1 NOD2 mRNA detected by Real-time PCR lung tissues. Results The expression (0.62±0.34)RQ value, (1.00±0.00)RQ (0.65±0.33)RQ value respectively.The was significantly lower than that...
Objective To investigate the potential roles of 14-3-3 in pathogenesis cervical cancer. Methods Tissues from 107 patients with cancer(cervical cancer group), 50 cases intraepithelial neoplasia (cervical group) and chronic cervicitis (chronic were obtained.Immunohistochemistry was performed to determine expression protein tissues three groups. Results The positive rate group(75.70%) significantly higher than that group group(42.00%, 30.00%, respectively)(χ2=17.00, 29.96, all P...
Abstract Background Lymphoepithelioma-like carcinoma(LELCC) is a rare variant of intrahepatic cholangiocarcinoma (ICC), LELCC composed prominently reactive lymphoid infiltration and scattered malignant epithelial cells, which may lead to misdiagnosis pathologist, especially on rapid freezing during operation. Recognizing the tumor important avoid misdiagnosis. Case presentation We report case in 53-year-old Chinese female patient with EBV infection, who was found have nodules junction left...