A5102752993- Cellular transport and secretion
- Adipose Tissue and Metabolism
- Sirtuins and Resveratrol in Medicine
- Microstructure and mechanical properties
- Ubiquitin and proteasome pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Endoplasmic Reticulum Stress and Disease
- Calcium signaling and nucleotide metabolism
- Advanced materials and composites
- Clinical practice guidelines implementation
- Powder Metallurgy Techniques and Materials
- Scoliosis diagnosis and treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sulfur Compounds in Biology
- Cardiac tumors and thrombi
- Diet and metabolism studies
- Phagocytosis and Immune Regulation
- Pharmaceutical industry and healthcare
- Congenital heart defects research
- Pressure Ulcer Prevention and Management
- Ion channel regulation and function
- Lung Cancer Diagnosis and Treatment
- Silk-based biomaterials and applications
- Histone Deacetylase Inhibitors Research
- Polyoxometalates: Synthesis and Applications
Tohoku University
2022-2024
State Key Laboratory of Respiratory Disease
2022
Third Affiliated Hospital of Guangzhou Medical University
2022
Guangzhou Medical University
2022
First Affiliated Hospital of Guangzhou Medical University
2022
Tongji University
2010-2020
Xiamen University
2013-2015
Guangzhou University of Chinese Medicine
2014
Shanghai Chest Hospital
1995
The HOPS complex serves as a tethering with GEF activity for Ypt7p in yeast to regulate late endosomal membrane maturation. While the role of is well established cells, its functional and mechanistic aspects mammalian cells are less defined. In this study, we report that RILP, downstream effector Rab7, interacts recruits subunits compartment. Structurally, amino-terminal portion RILP complex. Unexpectedly, interaction independent Rab7. VPS41 subunit was defined be major partner interacting...
Rab29 (also referred as Rab7L1) is a novel Rab protein, and recently demonstrated to regulate phagocytosis traffic from the Golgi lysosome. However, its roles in membrane trafficking have not been investigated extensively. Our results this study revealed that associated with trans-Golgi network (TGN), essential for maintaining integrity of TGN, because inhibition activity or depletion resulted fragmentation TGN marked by TGN46. Expression dominant negative form Rab29T21N shRNA-Rab29 also...
Abstract: Folic acid antioxidants were successfully intercalated into layered double hydroxides (LDH) nanoparticles according to a previous method with minor modification. The resultant folic acid-LDH constructs then characterized by X-ray powder diffraction and transmission electron microscopy. in vitro antioxidant activities, cytotoxicity effect, vivo antifatigue examined series of assays. results showed that system can scavenge 1,1-diphenyl-2-picrylhydrazyl hydroxyl free radicals chelate...
The subcellular location and cell biological function of small GTPase Rab40c in mammalian cells have not been investigated detail. In this study, we demonstrated that the exogenously expressed GFP-Rab40c associates with lipid droplets marked by neutral specific dye Oil red or Nile red, but Golgi endosomal markers. Further examination is also associated ERGIC-53 containing structures, especially under serum starvation condition. increasingly recruited to surface during formation maturation...
The influence of various Fe contents (5, 10, 20, and 40 wt.%) on the microstructure properties powder metallurgy Cu–Fe alloy by spark plasma sintering, subjected to cold rolling aging treatments, was explored. results showed that, with increasing content from 5 wt.% wt.%, distribution phase evolved discrete spheroid continuous stagger, accompanying its size 0.29 1.20 μm. Accordingly, yield strength aged increased 411.5 788.8 MPa, whilst electrical conductivity decreased 62.5% (IACS) 42.0%...
Several studies have associated reduced expression of synaptosomal-associated protein 25 kDa (SNAP-25) with schizophrenia, yet little is known about its role in the illness. In this paper, a forebrain glutamatergic neuron-specific SNAP-25 knockout mouse model was constructed and studied to explore possible pathogenetic schizophrenia. We showed that conditional (cKO) mice exhibited typical schizophrenia-like phenotype. A significantly elevated extracellular glutamate level detected cerebral...
Abstract RILP (Rab7-interacting lysosomal protein) is a key regulator for late endosomal/lysosomal trafficking, and probably tumor suppressor in prostate cancer. However, the role of other cancers underlying mechanism regulating invasion cancer cells remain to be investigated. In this study, we showed that overexpression breast inhibits migration invasion, whereas depletion by RNAi-mediated knockdown promotes invasion. We identified RalGDS (Ral guanine nucleotide dissociation stimulator) as...
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Resveratrol (RSV) has various pharmacological effects; however, few studies have directly addressed the possible antifatigue effects of long-term endurance exercise. The clinical use RSV is limited by its poor water solubility and extremely short plasma half-life. Solid lipid nanoparticles (SLNs) are considered as reasonable drug delivery systems to overcome some these drawbacks expand applications. In this study, RSV-SLNs were successfully prepared through emulsification low-temperature...
Successful wound healing depends on the reconstruction of proper tissue homeostasis, particularly in posttraumatic inflammatory microenvironment. Diabetes jeopardizes tissues' immune homeostasis cutaneous wounds, causing persistent chronic inflammation and cytokine dysfunction. Previously, we developed an autologous regeneration factor (ARF) technology to extract composite from restore promote healing. However, treatment efficacy was significantly compromised diabetic conditions. Therefore,...
The mechanism for different susceptibilities to obesity after short-term high-fat diet (HFD) feeding is largely unknown. Given the close association between occurrence and mitochondrial dysfunction, early events in skeletal muscle adaptations HFD-induced (DIO) resistant (DIO-R) lean phenotype under excess nutritional environment were explored.ICR/JCL male mice randomly divided into 2 groups, as follows: low-fat (LFD) HFD groups. After 6 weeks on HFD, HFD-fed classified DIO or DIO-R according...
Neuron-restrictive silencer factor (NRSF) is a zinc finger protein that acts as negative transcriptional regulator by recruiting histone deacetylases and other co-factors. It plays crucial role in nervous system development recently reported to be involved tumorigenesis tumor type-dependent manner; however, the of NRSF hepatocellular carcinoma (HCC) remains unclear. Here, we found expression was up-regulated 27 49 human HCC tissue samples examined. Additionally, mice with conditional...
RILP (Rab-interacting lysosomal protein) is a key regulator of transport and potential tumor suppressor. However, the role in prostate cancer underlying mechanism regulating proliferation, migration, invasion cells remain to be studied. In this study, we confirmed RalGDS (Ral guanine nucleotide dissociation stimulator) as interaction partner PC3 cells. Immunofluorescence microscopy showed that recruits compartment. We found inhibits activation RalA downstream effector RalBP1, negatively...
Abstract Myocardial damage due to dysfunctional myocardium has been increasing, and the prognosis of pharmacological device-based therapies remain poor. Isl1-expressing cells were thought be progenitor for cardiomyocyte proliferation after specific stimuli. However, true origin proliferating myocardiac role Isl1 in adult mammals unresolved. In this study, Isl1-CreERT2 knock-in mouse model was constructed using CRISPR/Cas9 technology. Using tamoxifen-inducible Isl1-CreERT/Rosa26R-LacZ system,...
Adolescent idiopathic scoliosis(AIS) is present in 2 to 4 percent of children between 10 and 16 years age, which seriously affects the mental physical health young people while defined as a lateral curvature spine greater than degrees accompanied by vertebral rotation. The main risk factors for curve progression are large magnitude, skeletal immaturity female gender. Previous studies have suggested possible direct relationship calmodulin progression, expression Calmodulin articular process...
The international trend of rehabilitation medicine is leaning towards the prevention metabolic disease these years. Especially in insulin resistance, exercise therapy has become an effective means rehabilitation. In view close association fatty acid metabolism with potential role Fatty Acids Translocase/CD36 (FAT/CD36) treatment aging-induced resistance been attracted more attentions. However, regulative FAT/CD36 improving sensitivity remains unclear. PURPOSE: To determine muscle resistance....
Objective: To investigate the effect of pelvic packing on control intractable postpartum hemorrhage after emergency perinatal hysterectomy (EPH). Methods: Eleven cases with complete clinical data due to failure hemostasis EPH were collected evaluate outcome, complications, hospital stay pregnant women, and analyze factors affecting packing. The included patients who admitted Third Affiliated Hospital Guangzhou Medical University treatment in other continuous bleeding or referred our for from...