A5078833825- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Regulation of Appetite and Obesity
- Olfactory and Sensory Function Studies
- Immune Response and Inflammation
- Prenatal Substance Exposure Effects
- Exercise and Physiological Responses
- Hormonal Regulation and Hypertension
- Fatty Acid Research and Health
- Neuropeptides and Animal Physiology
- Adenosine and Purinergic Signaling
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Parkinson's Disease Mechanisms and Treatments
- Adrenal Hormones and Disorders
- Evolutionary Psychology and Human Behavior
- Marine animal studies overview
- Dermatology and Skin Diseases
- Alcohol Consumption and Health Effects
Binghamton University
2016-2025
Alcohol Research Group
2017-2020
Janssen (United States)
2014
Janssen (Belgium)
2014
State University of New York
2011
University of Colorado Boulder
1995-2002
Wright-Patterson Air Force Base
2001
Naval Health Research Center
2001
Florida College
1997
University of Florida
1997
Peripheral immune stimulation such as that provided by lipopolysaccharide (LPS) has been reported to increase brain levels of IL-1beta mRNA, immunoreactivity, and bioactivity. Stressors produce many the same neural endocrine responses those follow LPS, but impact stressors on interleukin-1beta (IL-1beta) not systematically explored. An ELISA designed detect was used measure protein in rat brain. Brain explored after exposure inescapable shock (IS; 100 1.6 mA tail shocks for 5 sec each) LPS...
Exercise training produces a vast array of physiological adaptations, ranging from changes in metabolism to muscle mitochondrial biogenesis. Researchers studying the effects exercise often use animal models that employ forced regimens include aversive motivation, which could activate stress response. This study examined effect treadmill running (8 wk) on several systems are sensitive and stress. Forced produced both positive negative adaptations. Indicative exercised male Sprague-Dawley rats...
The nonpeptide CRH antagonist antalarmin has been shown to block both behavioral and endocrine responses CRH. However, it's potential activity in blunting sequelae of stressor exposure not assessed. Because antagonism central by α-helical attenuates conditioned fear responses, we sought test this regard. In addition, it remains unclear as whether is a result receptor blockade during conditioning or testing. Thus, explored mediates the induction expression (freezing context previously...
Adrenal glucocorticoids play an important role in mediating many of the behavioral and physiological effects exposure to stressors. Focus has been primarily on acute stress-induced rise [corticosterone (CORT) rat]. There are reports, however, that chronic stressors can produce increase basal CORT a decrease corticotropin-binding globulin (CBG). These changes occur subsequent CORT. The following experiments examined whether stressor (100 5-sec inescapable tail shocks; IS) could also long term...
This paper could not have been written without the financial and organizational support from Dieter Paulmann Jo Hastie respectively. Thanks are also due to two anonymous reviewers, whose comments on an earlier version of manuscript greatly improved paper. The views expressed in this those authors alone do represent Stellwagen Bank National Marine Sanctuary, U.S. Sanctuary Program, Southwest Fisheries Science Center, Service, NOAA and/or any other institution or agency. Correspondence...
This paper could not have been written without the financial and organizational support from Dieter Paulmann Jo Hastie respectively. Thanks are also due to 2 anonymous reviewers, whose comments on an earlier version of manuscript greatly improved paper. The views expressed in this those authors alone do represent Stellwagen Bank National Marine Sanctuary, U.S. Sanctuary Program, Southwest Fisheries Science Center, Service, NOAA and/or any other institution or agency. Correspondence...
Background Evidence has emerged demonstrating that ethanol ( E t OH ) influences cytokine expression within the central nervous system, although most studies have examined long‐term exposure. Thus, response to an acute challenge was investigated, in order characterize profiles of changes following Methods Rats pups were injected intraperitoneally (i.p.) with 2‐g/kg , and IL‐1 m RNA protein assessed 0, 60, 120, 180, 240 minutes post injection (Experiment 1). In Experiments 2 5, several...
In the central nervous system, ATP-gated Purinergic receptor P2X ligand-gated ion channel 7 (P2X7) is expressed in glial cells and modulates neurophysiology via release of gliotransmitters, including proinflammatory cytokine interleukin (IL)-1<i>β</i>. this study, we characterized JNJ-42253432 [2-methyl-<i>N</i>-([1-(4-phenylpiperazin-1-yl)cyclohexyl]methyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide] as a centrally permeable (brain-to-plasma ratio 1), high-affinity P2X7 antagonist with...
Exposing rats to a single session of inescapable tail shock (IS) reduces corticosteroid binding globulin (CBG) 24 h later (Fleshner et al., Endocrinology 136: 5336-5342, 1995). The present experiments examined whether reductions in CBG are differentially affected by controllable vs. identical uncontrollable shock, mediated IS-induced glucocorticoid elevation, or reflect activation the acute phase response and IS produces fever. results demonstrate that 1) equivalent observed escapable yoked...