A5090198042- Breast Lesions and Carcinomas
- Cancer and Skin Lesions
- Breast Cancer Treatment Studies
- Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Soft tissue tumors and treatment
- Monoclonal and Polyclonal Antibodies Research
- Global Cancer Incidence and Screening
- AI in cancer detection
- Lung Cancer Treatments and Mutations
- Metastasis and carcinoma case studies
- Genetic and rare skin diseases.
- Salivary Gland Tumors Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Ear and Head Tumors
- Neonatal Respiratory Health Research
- Soft tissue tumor case studies
- Cancer Immunotherapy and Biomarkers
- Breast Implant and Reconstruction
- Sarcoma Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Systemic Sclerosis and Related Diseases
- Lung Cancer Research Studies
- Nonmelanoma Skin Cancer Studies
WinnMed
2023-2025
Mayo Clinic in Florida
2022-2025
Jacksonville College
2022-2024
Cleveland Clinic
2019-2022
Lincoln Memorial University
2022
Montefiore Medical Center
2019-2020
Albert Einstein College of Medicine
2020
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2019
Duke University
2019
Northwell Health
2016-2018
Aims Due to its rarity and non‐specific clinical pathological features, low‐grade adenosquamous carcinoma (LGASC) of the breast continues pose diagnostic challenges. Unlike other triple‐negative carcinomas, LGASC tends have an indolent behaviour. It is essential recognise this lesion for accurate diagnosis appropriate management. Methods results Twenty‐five cases were identified in our archives collaborating institutes. Cases with dominant coexisting type carcinomas excluded. We studied...
Among gynecologic cancers, uterine serous carcinoma (USC) has been shown to be human epidermal growth factor receptor 2 (HER2) amplified and trastuzumab included in the recent National Comprehensive Cancer Network (NCCN) guidelines for treatment of advanced stage or recurrent USC with HER2 overexpression/amplification. There is limited literature suggesting that a subset high-grade endometrioid carcinomas aberrant p53 expression may also these patients could benefit from addition targeted...
Although carcinoma in situ has been accepted as a well-established concept and diagnostic category, for reasons unknown sebaceous not recognized yet general pathology or dermatopathology. Such lesions have always misinterpreted either benign neoplasm carcinoma. In the present essay, we provide convincing account supporting valid entity via critical literature review histopathological assessment illustration. Recognizing will certainly help to avoid misinterpretation subsequently under over...
Background: Glomus tumor is a benign neoplasm of the glomus body, neuromyoarterial structure that regulates temperature and pressure in cutaneous vasculature. Approximately 1%–4.5% tumors present hands females; these, 65% are seen subungual region index long fingers. Pacinian hyperplasia lesion corpuscle, mechanoreceptor located subcutis feet. Methods: A 65-year-old woman with history hand trauma 1-year chief complaint tingling, pain, burning sensations her proximal thumb underwent...
Mammary amyloid is an uncommon and easily overlooked pathological diagnosis with ambivalent presentation. Herein, we delineate the clinicopathological radiographic characteristics of mammary amyloid.The Department Pathology database was searched from 1993 to 2019 for keywords 'breast' 'amyloid', yielding 32 cases 23 patients, including consultation cases. All patients were female, age range = 52-81 (mean 67.4 years). The left breast involved more than right (43 versus 33%, respectively);...
Tumour-infiltrating lymphocytes (TILs) are prognostic in invasive breast cancer; however, their significance ductal carcinoma situ (DCIS) has not been established. The Oncotype DX (ODX) Breast DCIS Score test is a genomic assay used to predict the local recurrence risk. aims of this study were quantify TILs by use three methodologies, and correlate them with ODX Score.We studied 97 cases, all an Score. Cases low considered as one group, those intermediate/high together. quantified on...
Abstract: Lupus mastitis is a rare complication of systemic or discoid lupus erythematosus with an uncommon initial presentation when limited to the breast. In this article, we report 42-year-old woman who presented constant pain and tenderness in her breasts. Ultrasound imaging left breast revealed 14-mm oval mass, suspicious for malignancy; needle core biopsy was performed. Sections showed necrosis fat lobules associated mixed nodular lymphoplasmacytic aggregates. Karyorrhectic debris,...
Introduction. Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. Methods. A retrospective search our Pathology database from 2000 to 2021 identified 6 PST, all evaluated according Armed Forces Institute (AFIP) criteria. Immunohistochemistry for CD10, CD34, KIT, GATA3, p63, SOX10, ER, PR, HER2, smooth muscle actin (SMA), beta-catenin, and myogenin was performed as well. Results. All patients were female age ranged 29 55 years (mean...
Dermatofibromas (DFs) are common, benign, fibrohistiocytic tumors of the skin. Clinically, if they present in a rapid succession, termed multiple eruptive DFs. When arise localized distribution, clustered dermatofibromas (MCDFs). These DF variants rare, and subtype DFs has been associated with autoimmune diseases, hypertriglyceridemia, pregnancy, HIV, primary pulmonary hypertension. Conversely, there is paucity published clinical associations MCDF.A 23-year-old white woman arterial...
Cutaneous leiomyomata, which are benign smooth muscle neoplasms, commonly present as dermal-based nodules or papules with borders and firm consistency. Digital, particularly subungual leiomyomata quite rare. A 16-year-old female presented to nail clinic complaining of discoloration the lunula left thumbnail for 2.5 months. On initial examination, a pink longitudinal band was in center plate, yellow distal onycholysis. The patient had only mild tenderness palpation, did not recall trauma...
Recent trials demonstrated clinically significant benefits in HER2-nonamplified breast cancer with HER2-low expression using novel anti-HER2 antibody-drug conjugates. Thus, was proposed as a separate diagnostic entity. Herein, we reclassify HER2-negative cancers according to the new category modified system and further investigate HER2-very-low expression.114 HER2 immunohistochemistry (IHC)-negative invasive tumors were identified from pathology database of Mayo Clinic, Jacksonville, FL,...
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), set of national standards teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, Diagnostic Medicine Therapeutic Pathology. For additional information, full list objectives all competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.1.
Collision tumors are rare neoplasms that consist of at least two different cell lineages the same site. Given many possible combinations can occur, collision tumors, while rare, have been reported in multiple locations such as stomach, bladder, and thyroid. rarely found breast tissue, with only a few cases literature. We herein report unique case 79-year-old woman history melanoma who presented left mass was subsequently to invasive ductal carcinoma (IDC) metastatic tissue. This is one first...
Papillary carcinoma of the breast is a rare histologic subtype invasive cancer. In contrast, ductal in situ (DCIS) noninvasive, nonobligate precursor to mammary carcinoma, confined within terminal duct lobular unit and surrounded by an intact myoepithelial cell layer at stromal/epithelial interface. We present unusual case which patient with only DCIS exhibited papillary sentinel lymph node, leading questions about origin node lesion-whether it represents true metastasis or iatrogenic...
NGS used to diagnose and treat NSCLC patient with initial concern for metaplastic breast cancer.