A5059955514- Forensic and Genetic Research
- Digestive system and related health
- Yersinia bacterium, plague, ectoparasites research
- Isotope Analysis in Ecology
- T-cell and B-cell Immunology
- Pacific and Southeast Asian Studies
- Rabies epidemiology and control
- Archaeology and ancient environmental studies
- Inflammatory Bowel Disease
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Water management and technologies
- Marine Bivalve and Aquaculture Studies
- Dermatology and Skin Diseases
- Genetics, Aging, and Longevity in Model Organisms
- History of Medicine Studies
- Mycobacterium research and diagnosis
- Leprosy Research and Treatment
- Microbial infections and disease research
- Pleistocene-Era Hominins and Archaeology
- Race, Genetics, and Society
- Coral and Marine Ecosystems Studies
Kiel University
2022-2025
University Hospital Schleswig-Holstein
2023
University of Lübeck
2023
Abstract Background The northern European Neolithic is characterized by two major demographic events: immigration of early farmers from Anatolia at 7500 years before present, and their admixture with local western hunter-gatherers forming late farmers, around 6200 present. influence this event on variation in the immune-relevant human leukocyte antigen (HLA) region understudied. Results We analyzed genome-wide data 125 individuals seven archeological farmer sites located present-day Germany....
We present a robust radiocarbon (
Variation in apolipoprotein E (APOE) has been shown to have the strongest genetic effect on human longevity. The aim of this study was unravel evolutionary history three major APOE alleles Europe by analysing ancient samples up 12,000 years old. We detected significant allele frequency shifts between populations and over time. Our analyses indicated that selection led large differences earliest European (i.e., hunter-gatherers vs. first farmers), possibly due changes diet/lifestyle. In...
Abstract Understanding the factors that predispose species and populations to decline extinction is a major challenge of biodiversity research. In present study, we investigated historical population genomics an extinct oyster from Wadden Sea collected between 1868 1888, compared it French British sampled at same time. The unique habitat on northern edge European distribution. Our museomic results indicate now-extinct was genetically isolated had lower nuclear genomic diversity than examined...
ABSTRACT The northern European Neolithic is characterized by two major demographic events: immigration of early farmers (EF) from Anatolia (5500 BCE) and their admixture (from ∼4200 with western hunter-gatherers (WHG) forming late (LF). influence this event on variation in the immune-relevant human leukocyte antigen (HLA) region understudied. Here, we conducted population immunogenetic analyses 83 individuals six EF LF sites located present-day Germany. We observed significant shifts HLA...
Abstract Background Leprosy is a chronic infectious disease caused by Mycobacterium leprae ( M. ) that reached an epidemic scale in the Middle Ages. Nowadays, absent Europe and host genetic influences have been considered as contributing factor to leprosy disappearance. In this study, case-control association analysis between multiple human leukocyte antigen (HLA) alleles was performed medieval European population for first time. The sample comprised 293 individuals from 18 archaeological...
Summary Background The hypomorphic variant rs11209026-A in the IL23R gene provides significant protection against immune-related diseases Europeans, notably inflammatory bowel disease (IBD). Today, A-allele occurs with an average frequency of 5% Europe. Methods This study comprised 251 ancient genomes from Europe spanning over 14,000 years. In these samples, investigation focused on admixture informed analyses and selection scans its haplotypes. Findings was found at high frequencies...
Yersinia pestis has been infecting humans since the Late Neolithic (LN). Whether those early infections were isolated zoonoses or initiators of a pandemic remains unclear. We report Y. in two individuals (of 133) from LN necropolis at Warburg (Germany, 5300-4900 cal BP). Our analyses show that genomes belong to distinct strains and reflect independent infection events. All known today (n = 4) are basal phylogeny represent separate lineages probably originated different animal hosts. In LN,...
<title>Abstract</title> <italic>Yersinia pestis</italic> (<italic>Y. pestis</italic>) has been infecting humans since the Late Neolithic (LN). Whether those early infections were isolated zoonoses or initiators of a prehistoric Eurasia-wide pandemic remains unclear. We report results pathogen screening on 133 LN human from necropolis at Warburg (Germany, 5300 − 4900 cal BP). identify two new <italic>Y. genomes individuals buried in different gallery graves. Our analyses show that belong to...
Abstract We present the first robust radiocarbon ( 14 C) chronology for prehistoric burial activity at Sakhtysh, in European Russia, where nearly 180 inhumations attributed to Lyalovo and Volosovo pottery‐using hunter‐gatherer‐fishers represent largest known mortuary populations of these groups. Past attempts C dating were restricted by poor preservation limited understanding diet dietary reservoir effects (DREs). obtained 32 new AMS (Accelerator Mass Spectrometry) dates on human petrous...
Abstract Inflammatory bowel disease (IBD) is often described as a model for modern civilization diseases in which environmental factors trigger manifestation genetically compromised individuals. Little known about the evolutionary history of variants associated with IBD Europeans. Here, we analysed 610 IBD-variants 2445 ancient datasets from human remains spanning last 12,000 years, including genotypes generated 172 newly collected individuals European Neolithic. We found statistically...