A5068614870- Regulation of Appetite and Obesity
- Fatty Acid Research and Health
- Estrogen and related hormone effects
- EEG and Brain-Computer Interfaces
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Fungal and yeast genetics research
- Antibiotic Use and Resistance
- Biochemical Analysis and Sensing Techniques
- Cholesterol and Lipid Metabolism
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Antibiotic Resistance in Bacteria
- Vitamin D Research Studies
- Amino Acid Enzymes and Metabolism
- Biochemical effects in animals
- Phytoestrogen effects and research
- Liver physiology and pathology
- Diabetes Management and Education
- Bone health and osteoporosis research
- Inflammatory mediators and NSAID effects
- Diabetic Foot Ulcer Assessment and Management
- Listeria monocytogenes in Food Safety
- Enterobacteriaceae and Cronobacter Research
Sapienza University of Rome
1995-2022
Institute of Molecular Biology and Pathology
2019-2020
University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
2019
Grigore T. Popa University of Medicine and Pharmacy
2006-2013
University of Milan
2005-2008
University of Toronto
2007
Villa Melitta
2006
University of L'Aquila
2002-2006
Physiopathologie et Epidémiologie des Maladies Respiratoires
2006
Istituto Pasteur
1997-1998
Background and purpose: Ghrelin, a gut‐brain peptide, is considered gastroprotective factor in gastric mucosa. We investigated the role of prostaglandins (PG) possible interplay between PGs nitric oxide (NO) ghrelin gastroprotection against ethanol (EtOH)‐induced lesions. Experimental approach: examined effects (1) central (4 μg per rat) injection on PGE 2 accumulation normal or EtOH–lesioned mucosa, (2) pretreatment with indomethacin (10 mg kg −1 , p.o.), non‐selective cyclooxygenase (COX)...
Nephropathic cystinosis is a lysosomal disorder caused by functional defects of cystinosin, which mediates cystine efflux into the cytosol. The protein sequence contains at least two signals that target to compartment, one located carboxy terminal tail (GYDQL). We have isolated from human kidney cDNA library cystinosin isoform, generated an alternative splicing exon 12 removes GYDQL motif. Based on its last three amino acids, we termed this cystinosin-LKG. Contrary expression experiments...
Ghrelin, the endogenous ligand of GH secretagogue receptor (GHS-R) has been previously shown to inhibit gastric acid secretion in pylorus-ligated rats. Two isoforms GHS-R have identified: GHS-R(1a) and GHS-R(1b). The present study aimed: (i) characterise type involved central inhibitory activity ghrelin by using des-octanoyl ghrelin, synthetic agonist (EP1572) antagonist (D-Lys(3)-GHRP-6) (ii) investigate relationship between cortistatin (CST) control natural neuropeptide CST-14 octapeptide...
ABSTRACT In Saccharomyces cerevisiae the Lysine-acetyltransferase Gcn5 (KAT2) is part of SAGA complex and responsible for histone acetylation widely or at specific lysines. this paper we report that GCN5 deletion differently affects growth two strains. The defective mitochondrial phenotype related to a marked decrease in mtDNA content, which also involves regions molecule. We show wild-type mitochondria protein present mitoplasts, suggesting new function independent from possibly connecting...
In a retrospective study, 68 patients with Spinal Epidural Abscess (SEA) were reviewed. Of these, 66% had different predisposing factors such as staphylococcal skin infections, surgical procedures, rachicentesis, trauma, spondilodiscitis. lumbar region location in 53% of cases. Staphylococcus aureus was the most frequent etiological agent (81%). The overall rate mortality SEA 13.2%.
KAT Gcn5 and DUB Ubp8 are required for respiration mitochondria functions in budding yeast, this study we show that loss of respiratory activity is acquired over time. Interestingly, absence allows cells to grow hypoxic conditions with altered mitophagy. Comparatively, the aggressive glioblastoma (GBM) multiforme tumor shows survival mechanisms able overcome hypoxia brain. Starting from yeast our findings on role hypoxia, extended analysis human ortholog signature cancer gene Usp22...
"Computed Tomography and Ultrasonography of the Adrenal Glands in Paracoccidioidomycosis. Comparison with Cortisol Aldosterone Responses to ACTH Stimulation" published on Jan 1991 by The American Society Tropical Medicine Hygiene.
The human estrogen receptor α ( ER ) gene is driven by multiple promoters, of which the F promoter alone found to be active in primary osteoblasts. study was aimed at identifying new regulatory pathways affecting transcription this cell lineage. We generated osteoblast-like cells, Saos-2, stably transfected with a luciferase-reporter downstream ERα (Saos F-Luc), and assayed reporter response differentiation-related signals. Over-confluence, shown stimulate osteoblast differentiation, caused...
We propose a study showing novel role of Gcn5p and Ubp8p in the process ubiquitylation yeast proteome which includes main glycolytic enzymes. Interestingly, absence glucose consumption redox balance were altered yeast. believe that these results sugar metabolism might open new perspectives research leading to protocols for counteracting enhanced glycolysis tumors.
The fate of [ 3 H]cholesterol carried in chylomicrons prepared from rats given a meal palm oil (rich long‐chain saturated fatty acids), olive monounsaturated acids) or corn n –6 polyunsaturated was investigated vivo fed low‐fat diet supplemented with the corresponding (to provide 40% calories) for 21 days. In low‐fat‐fed groups, radioactivity removed blood and secreted into bile over 180 min more rapidly when were derived as compared to oil. After feeding high‐fat diets, however, both...
The experiment used a patented psycho-verbal stimulation interface to study the utility of cognitive visual N400 evoked potential in detecting reading process. acquisition was performed Oz, Pz, Cz, Fz leads, on group 50 normal persons, at three type list contained each 500 paragraphic modified words: unreadable non-words, readable non-words and pseudowords. Grand AVG function for average-group recordings task statistic SPSS software based ANOVA method identify differences amplitude per 17...