A5065161101- Mosquito-borne diseases and control
- Insect Pest Control Strategies
- Malaria Research and Control
- Dengue and Mosquito Control Research
- Insect and Pesticide Research
- Viral Infections and Vectors
- Insect Resistance and Genetics
- Insect symbiosis and bacterial influences
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Cholinesterase and Neurodegenerative Diseases
- Iron Metabolism and Disorders
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Insect behavior and control techniques
- Viral Infections and Outbreaks Research
- Trace Elements in Health
- Multiple Sclerosis Research Studies
- Immunotherapy and Immune Responses
- Neurological Disorders and Treatments
- Long-Term Effects of COVID-19
- Hepatocellular Carcinoma Treatment and Prognosis
Autonomous University of Yucatán
2018-2024
Secretaría de Investigación, Innovación y Educación Superior
2020-2021
Universidad Autónoma de Nuevo León
2014-2018
Center of Molecular Immunology (Cuba)
2002
The extensive reliance on insecticides to control Aedes aegypti mosquitoes and disrupt transmission of dengue, chikungunya Zika has fueled the emergence widespread resistance insecticides. Mismatch between frequency pyrethroid in occurrence pyrethroid-based insecticide applications for vector is often hypothesized be due household use commercial products. We experimentally quantified phenotypic genotypic responses four Ae. strains (three field, resistant, one laboratory, susceptible) after...
Background In the absence of vaccines or drugs, insecticides are mainstay Aedes -borne disease control. Their utility is challenged by slow deployment resources, poor community compliance and inadequate household coverage. Novel application methods required. Methodology principal findings A 10% w/w metofluthrin “emanator” that passively disseminates insecticide from an impregnated net was evaluated in a randomized trial 200 houses Mexico. The devices were introduced at rate 1 per room...
We conducted a baseline characterization of the abundance and seasonality Aedes aegypti (Linnaeus, 1762)-a vector dengue, chikungunya, Zika-in two suburban localities Yucatan, Mexico, as first step in implementation an integrated management (IVM) plan combining 'traditional control' (source reduction/truck-mounted ultra-low volume [ULV] spraying) incompatible insect technique/sterile technique for population suppression Mexico. Weekly entomological collections with ovitraps BG-sentinel traps...
Abstract Insecticide-based approaches remain a key pillar for Aedes -borne virus (ABV, dengue, chikungunya, Zika) control, yet they are challenged by the limited effect of traditional outdoor insecticide campaigns responding to reported arboviral cases and emergence resistance in mosquitoes. A three-arm Phase II unblinded entomological cluster randomized trial was conducted Merida, Yucatan State, Mexico, quantify impact targeted indoor residual spraying (TIRS, application insecticides Ae....
Resistance to the organophosphate insecticide chlorpyrifos was evaluated in females from six strains of Aedes aegypti (L.) that expressed high levels cross-resistance eight pyrethroid insecticides. Relative LC50 and LC90 at 24 h a susceptible New Orleans (NO) strain, three were highly resistant (Coatzacoalcos, resistance ratio [RRLC90] = 11.97; Pozarica, RRLC90 12.98; Cosoleacaque, RRLC50 13.94 17.57), one strain moderately (Veracruz, 5.92), two (Tantoyuca Martinez de la Torre, < 5) bottle...
Background There is an increased need to mitigate the emergence of insecticide resistance and incorporate new formulations modes application control urban vector Aedes aegypti . Most research development for Ae has focused on their peridomestic use as truck-mounted ULV-sprays or thermal fogs despite widespread knowledge that most resting are found indoors. A recent modification indoor residual spraying (IRS), termed targeted IRS (TIRS) works by restricting applications 1.5 m down floor key...
Iron and copper chelation restricts Plasmodium growth in vitro mammalian hosts. The parasite alters metal homeostasis red blood cells to its favor, for example metabolizing hemoglobin hemozoin. Metal interactions with the mosquito have not, however, been studied. Here, we describe metallomes of Anopheles albimanus Aedes aegypti throughout their life cycle following a meal. Consistent previous reports, found evidence maternal iron deposition embryos Ae. aegypti, but less so An. albimanus....
Vector control methods that mobilize and impact rapidly during dengue, Zika, chikungunya outbreaks are urgently needed in urban contexts. We investigated whether one person using a handheld aerosolized insecticide could achieve efficacy levels comparable to targeted indoor residual spraying (TIRS), pyrethroid-resistant
Introduction: The vector-borne diseases program in México has an established network of ovitraps for entomological surveillance Aedes spp. In response to reports albopictus the periphery Mérida, state capital Yucatán, Ministry Health increased specificity this surveillance. Objective: To describe presence and distribution Ae. Mérida its relative abundance compared aegypti vector control program. Materials methods: During October, 2019, 91 were randomly selected from 31 neighborhoods Mérida....
Abstract While residual insecticide applications have the potential to decrease pathogen transmission by reducing density of vectors and shifting age structure adult mosquito population towards younger stages development, this double entomological impact has not been documented for Aedes aegypti . collected from households enrolled in a cluster-randomized trial evaluating epidemiological targeted indoor spraying (TIRS) Merida, Mexico, were dissected their characterized Polovodova combined...
We evaluated the efficacy of aerial ultra-low-volume (ULV) insecticide spraying in field bioassays with caged Aedes aegypti May 2017 Puerto Vallarta, Jalisco, Mexico. The insecticides tested included an organophosphate (Mosquitocida UNO ULV) and a neonicotinoid-pyrethroid combination (Cielo). Two Ae. populations were evaluated: pyrethroid-resistant local strain (Puerto Vallarta) insecticide-susceptible laboratory (New Orleans). Knockdown after 1 h by both products was ≥97.0%, mortality 24...
We evaluated the efficacy of bendiocarb (Ficam W® 80%) and pirimiphos-methyl (Actellic 300CS® 28.16%), applied to different surfaces potentially sprayable within houses during application a targeted indoor residual spraying (TIRS) against field pyrethroid-resistant strain Aedes aegypti. Bioassays with cones were performed on cement (walls), wood (doors), textile (cloth) typical in Mexican city Merida (n = 10). Optimal (>80% mean mortality) ranged from 3 months (cement) 2 (wood textiles)....
Background With the recent occurrence of locally transmitted Aedes -borne viruses in continental United States and Europe, a lack effective vaccines, new approaches to control aegypti albopictus are needed. In sub-tropical urban settings US, Ae . is dominant nuisance arbovirus vector species. Unfortunately, toolbox against not as well developed for Here, we evaluate efficacy, longevity, range protectiveness novel passive metofluthrin emanator (10% active ingredient polyethylene mesh) indoors...
ABSTRACT We report results of susceptibility tests for Aedes taeniorhynchus from 2 localities Yucatan State, Mexico, to different insecticides. The Centers Disease Control and Prevention bottle bioassays were performed using the active ingredients 3 pyrethroids, organophosphates, 1 carbamate: permethrin (15 μg/ml), deltamethrin (10 alpha-cypermethrin malathion (50 chlorpyrifos (85 bendiocarb (12.5 μg/ml). mortality recorded at diagnostic time exposure (30 min) was 100% with all insecticides...
Here we report the residual efficacy of neonicotinoid insecticide clothianidin against pyrethroid-resistant Aedes aegypti. We first conducted a range-finding evaluation on three different substrates (wall, wood, cloth) using doses (100, 300 and 600 mg a.i. m
Abstract Background Mexico has experienced a significant reduction in malaria cases over the past two decades. Certification of localities as malaria-free areas (MFAs) been proposed steppingstone before elimination is achieved throughout country. The Mexican state Quintana Roo candidate for MFA certification. Monitoring status insecticide susceptibility major vectors crucial This study describes Anopheles albimanus, main vector, from historically important foci Roo, using both phenotypic and...
Wolbachia pipientis (Hertig, 1936), also referred as Wolbachia, is a bacterium present across insect taxa, certain strains of which have been demonstrated to impact the fitness and capacity transmit viruses in mosquitoes, particularly Aedes aegypti (Linnaeus, 1762). Most studies examine these impacts limited sets environmental regimes. Here we seek understand environmentally relevant conditions such larval density, temperature, their interaction on wAlbB-infected A. aegypti. Using factorial...
Aedes mosquito-borne viruses (ABVs) place a substantial strain on public health resources in the Americas. Vector control of mosquitoes is an important strategy to decrease or prevent spread ABVs. The ongoing Targeted Indoor Residual Spraying (TIRS) trial NIH-sponsored clinical study efficacy novel, proactive vector technique dengue virus (DENV), Zika (ZIKV), and chikungunya (CHIKV) infections endemic city Merida, Yucatan, Mexico. primary outcome laboratory-confirmed ABV neighborhood...
There is a pressing need for innovative strategies to control arboviruses transmitted by Aedes aegypti. The modification of indoor residual spraying target Ae. aegypti one such strategy. A clinical trial quantifying the epidemiologic impact targeted used product with pirimiphos-methyl as active ingredient in city Mérida, Mexico. To monitor susceptibility local populations over course trial, we calculated diagnostic dose using Centers Disease Control and Prevention bottle assay. Two...
Commercial aerosolized insecticides can be implemented as a community-based approach to targeted indoor residual spraying against Aedes aegypti, but their efficacy on pyrethroid-resistant mosquitoes has not yet been evaluated. Two commercial products (H24 Poder Fulminante Ultra Eficaz®, carbamate, and Baygon Verde®, pyrethroid) were sprayed common surfaces e.g., cement, plywood, cloth, tested for susceptible field-derived Ae. aegypti strains using the WHO cone bioassays. Overall, ≥80% 24-h...
ABSTRACT In recent years, Aedes albopictus has become the most important invasive mosquito species worldwide. 2018, Ae. was found in a suburban area of Merida, one cities with highest number arbovirus cases Mexico last 10 years. As continues its range expansion, there is need to monitor susceptibility existing insecticide classes, since countries like currently do not consider management programs. order determine insecticides usually applied by vector control program Mexico, Centers for...