A5101417855- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Aging, Health, and Disability
- Social Sciences and Policies
- Public Health and Environmental Issues
- Trypanosoma species research and implications
- Nursing care and research
- Stress and Burnout Research
- Public Health and Social Inequalities
- Psychological Treatments and Disorders
- Ethics and bioethics in healthcare
- Child and Adolescent Psychosocial and Emotional Development
- Psychology Research and Bibliometrics
- Coccidia and coccidiosis research
- Health and Medical Education
- Suicide and Self-Harm Studies
- Cancer-related Molecular Pathways
- Virus-based gene therapy research
- Pancreatic and Hepatic Oncology Research
- Public Health Policies and Education
- Educational methodologies and cognitive development
- Medical Malpractice and Liability Issues
- Protein Tyrosine Phosphatases
- Philosophical and Cultural Analysis
- Sustainability in Higher Education
Centro Tecnológico Nacional de la Conserva y Alimentación
2024
Universidade de Vigo
2023
University of Chile
2000-2022
Universidade de Santiago de Compostela
2021
Hospital San Borja Arriarán
2021
Hospital Universitario Fundación Jiménez Díaz
2019
National University of Misiones
2019
Sanford Burnham Prebys Medical Discovery Institute
2011
University of California, San Diego
2008-2010
University of Michigan
2010
Recent breakthroughs in creating induced pluripotent stem cells (iPSCs) provide alternative means to obtain embryonic stem-like without destroying embryos by introducing four reprogramming factors (Oct3/4, Sox2, and Klf4/c-Myc or Nanog/Lin28) into somatic cells. iPSCs are versatile tools for investigating early developmental processes could become sources of tissues regenerative therapies. Here, the first time, we describe a strategy analyze genomics datasets mouse fibroblasts (MEFs)...
Abstract Background The molecular events and evolutionary forces underlying lethal mutagenesis of virus (or extinction through an excess mutations) are not well understood. Here we apply for the first time phylogenetic methods Partition Analysis Quasispecies (PAQ) to monitor genetic distances intra-population structures mutant spectra foot-and-mouth disease (FMDV) quasispecies subjected by base nucleoside analogues. Results Phylogenetic PAQ analyses have revealed a highly dynamic variation...
<h3>Importance</h3> Immigrants are at an increased risk for co-occurring mental health and substance misuse symptoms; however, effective treatments lacking. <h3>Objective</h3> To evaluate the effectiveness of Integrated Intervention Dual Problems Early Action (IIDEA) program compared with enhanced usual care. <h3>Design, Setting, Participants</h3> This randomized clinical trial was conducted from September 2, 2014, to February 2017, in 17 clinics or emergency departments 24 community sites...
The main objective of this study is to figure out the volume and evolution Spanish scientific production in Psychology based data provided by databases Web Science (Thomson Reuters) Scopus (Elsevier) during years 2000-2009. It proposed determine which are journals used most psychologists spread their research at an international level; compare coverage overlap documents that present both databases. Quantitative offered, as well possible correlation between studied analyzed, such increase...
It is generally accepted that longer microsatellites mutate more frequently in defective DNA mismatch repair (MMR) than shorter microsatellites. Indeed, we have previously observed the A10 microsatellite of transforming growth factor beta type II receptor (TGFBR2) frameshifts −1 bp at a faster rate A8 activin (ACVR2), although both genes become frameshift-mutated >80% MMR-defective colorectal cancers. To experimentally determine effect length upon frameshift mutation gene-specific sequence...
The characterization of the gene encoding Leishmania donovani phosphofructokinase (PFK) and biochemical properties expressed enzyme are reported. L. has a single PFK copy per haploid genome that encodes polypeptide with deduced molecular mass 53 988 pI 9.26. predicted amino acid sequence contains C‐terminal tripeptide conforms to an established signal for glycosome targeting. showed most similarity inorganic pyrophosphate (PP i )‐dependent PFKs, despite being ATP‐dependent. It thereby...
Microsatellite instability promotes colonic tumorigenesis through generating frameshift mutations at coding microsatellites of tumor suppressor genes, such as TGFBR2 and ACVR2. As a consequence, signaling these TGFbeta family receptors is abrogated in DNA Mismatch repair (MMR)-deficient tumors. How occur real time mutational rates human sequences have not previously been studied. We utilized cell lines with different MMR deficiencies (hMLH1-/-, hMSH6-/-, hMSH3-/-, MMR-proficient) to...
Several studies indicate that the DNA mismatch repair (MMR) system may trigger cytotoxicity upon 5-fluorouracil (5-FU) recognition, but signaling pathways regulated by MMR in response to 5-FU are unknown. We hypothesize recognition of proteins specific cascades results slowing cell cycle and death. Whole human genome cDNA microarrays were used examine relative responses induced MMR-proficient cells after (5μM) treatment for 24 hours. Analysis revealed 43 differentially affected compared...
Introduccion: La Psiquiatría Infantil es una especialidad relativamente reciente. Es un área importante de trabajo ya que los datos reflejan la tasa prevalencia trastornos mentales en niños y adolescentes se sitúa entre el 15 20 % población infanto-juvenil a nivel mundial, o 80 adultos tuvieron comienzo antes 18 años. En toda España puede ofrecer asistencia adolescentes, aunque ésta no encuentra homogeneizada todas las Comunidades Autónomas (CCAA). Adicionalmente, uno dos únicos países Unión...
Resulta indiscutido que el daño es elemento central de la responsabilidad civil. Así, este artículo muestra forma en legislación ha optado por no definirlo mientras doctrina chilena pasado alto su problematización, prefiriendo abordar ámbito práctico, clasificándolo, caracterizándolo y luego reflexionando torno a sus formas cuantificarlo dinero. Pero desde óptica filosofía del derecho justicia correctiva, resulta relevante evidenciar esta paradoja principal civil sea infraproblematizado y,...
Antecedentes: La asociación entre el parkinsonismo y lupus eritematoso sistémico está insuficientemente descrita y, hasta la fecha, los mecanismos fisiopatológicos subyacentes no están completamente establecidos, abarcando desde alteraciones vasculares fenómenos inmunomediados. El análisis de literatura identificó solo 28 casos en pacientes con sistémico, destacando limitada atención a estas asociaciones sus respectivos enfoques terapéuticos. Reporte Caso: Presentamos caso un paciente una...
El presente documento expone los resultados de un análisis preferencias profesionales realizado a estudiantes sexto semestre bachillerato en las instituciones dentro del área influencia Tecnológico Superior Jalisco “Mario Molina” Unidad Académica Cocula. estudio, desarrollado con enfoque cualitativo e interpretativo, incluyó entrevistas 151 jóvenes. Se lograron identificar tendencias cuanto la preferencia profesional, universidad elección, carrera primera opción, el horario preferencia,...
Las experiencias y aprendizaje de la comunidad universitaria son esenciales para aspirar al cambio que Agenda 2030 pretende, transitar hacia cultura del desarrollo sostenible. Entre los currículos universitarios, explorar presencia Objetivos Desarrollo Sostenible (ODS) en formación futuros profesionales sanitarios es fundamental. Un hilo transversal todos ODS salud. Su importancia explícita el 3 “Salud bienestar”, pero una cuestión consustancial todo proyecto. La Enfermería, por su impacto...
Intellectual disability (ID) is a neurodevelopmental disorder characterized by limitations in intellec tual and adaptive functioning, of various etiologies, including genetic causes.to describe studies carried out series children adolescents with ID previously undetermined etiology, considering their phenotypic characteristics.Descriptive study patients aged 6 to 18 years. Clinical records, cognitive assessment results (Wechsler -TADI), performed were reviewed. They classified according...
la equidad en salud es un valor ligado al concepto de derechos humanos y justicia social. Busca que las personas puedan desarrollar su máximo potencial independientemente posición Para articular estrategias específicas orientadas a los profesionales sanitarios, se impone una reforma metodología docente, explorar innovaciones promuevan el aprendizaje, exponiendo estos retos sanitarios comunitarios globales, fomentando concienciación con equidad, desigualdades determinantes sociales salud. El...
El currículum en educación se construye y eso no lo hace indiferente a los contextos que configura. Partiendo de dicha premisa, este trabajo busca examinar, mediante una revisión aproximativa, las causas históricas han influido la construcción del Grado Enfermería España desde perspectiva su misión social equidad. Para ello, realizó un análisis documental textos historiográficos jurídicos método inductivo. La bibliográfica efectuada permitió concluir actualidad reclama diseñado desarrollado...
RESUMEN Se evaluo el valor predictivo de exito terapeutico una fraccion semipurificada 0,05) y siendo 5 los 6 sueros corderos tratados, negativos a ELISA despues meses p.t. Mediante WB, se determino que 2 p.t., la mitad ovinos tratados no lograron reconocer las bandas 29 14 kDa (consideradas como altamente sensibles especificas en diagnostico fasciolosis). Hubo diferencias significativas proporcion positivos entre controles (p < 0,05). A hubo total ausencia reconocimiento 30 tratados. Los...