A5030634370- Hepatitis C virus research
- Viral gastroenteritis research and epidemiology
- Hepatitis B Virus Studies
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Mosquito-borne diseases and control
- RNA and protein synthesis mechanisms
- Hepatitis Viruses Studies and Epidemiology
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Liver Disease Diagnosis and Treatment
- Respiratory viral infections research
- Plant Virus Research Studies
- Malaria Research and Control
- Bacteriophages and microbial interactions
- SARS-CoV-2 and COVID-19 Research
- Vector-Borne Animal Diseases
- Virology and Viral Diseases
- HIV/AIDS drug development and treatment
- Virus-based gene therapy research
- T-cell and Retrovirus Studies
- Vibrio bacteria research studies
- Microbial infections and disease research
- Biochemical and Molecular Research
Universidad de la República
2015-2024
Institut Pasteur de Montevideo
2021
Comisión Sectorial de Investigación Científica
2021
Creative Research Enterprises (United States)
2021
Jackson and Tull (United States)
2021
Escuela Colombiana de Carreras Industriales
2019
Pontificia Universidad Javeriana
2019
Universidad de Montevideo
2011-2015
Universidad La República
2015
Centro Uruguayo de Imagenología Molecular
2004-2011
RNA synthesis by the paramyxovirus respiratory syncytial virus, a ubiquitous human pathogen, was found to be more complex than previously appreciated for nonsegmented negative-strand viruses. Intracellular replication of plasmid-encoded "minigenome" analog viral genomic directed coexpression N, P, and L proteins. But, under these conditions, greater part mRNA terminated prematurely. This difference in processivity between replicase transcriptase unanticipated because two enzymes ostensively...
ABSTRACT Hepatitis A virus (HAV) is a positive-stranded RNA in the genus Hepatovirus family Picornaviridae . So far, analysis of genetic variability HAV has been based on two discrete regions, VP1/2A junction and VP1 N terminus. In this report, we determined nucleotide deduced amino acid sequences complete gene 81 strains from France, Kosovo, Mexico, Argentina, Chile, Uruguay compared them with seven isolated elsewhere. Overall strain variation was found to be as high 23.7% at level 10.5%...
Hepatitis C virus (HCV) has high genomic variability and, since its discovery, at least six different types and an increasing number of subtypes have been reported. Genotype 1 is the most prevalent genotype found in South America. In present study, three regions (5′UTR, core NS5B) four HCV strains isolated from Peruvian patients were sequenced order to investigate congruence genotyping for these regions. Phylogenetic analysis using 5′UTR–core sequences strain PE22 be related subtype 1b....
The genetic material of the three domains life (Bacteria, Archaea, and Eukaryota) is always double-stranded DNA, their GC content (molar guanine plus cytosine) varies between ≈ 13% 75%. Nucleotide composition simplest way characterizing genomes. Despite this simplicity, it has several implications. Indeed, main factor that determines, among other features, dinucleotide frequencies, repeated short DNA sequences, codon amino acid usage. Which forces drive strong variation still a matter...
Preceding and following each gene of respiratory syncytial virus (RSV) are two conserved sequences, the gene-start (GS) gene-end (GE) motifs, respectively, which thought to be transcription signals. The functions boundaries these signals process sequential were analyzed with cDNA-encoded RNA analogs (minigenomes) nonsegmented negative-sense RSV genomic RNA. Two minigenomes used. monocistronic RSV-CAT minigenome consists chloramphenicol acetyltransferase (CAT) translational open reading frame...
Abstract Genetic analysis of selected genome regions hepatitis A Virus (HAV) suggested that distinct genotype could be defined in different geographic locations. In order to study the degree genetic variability among HAV isolated during a single epidemic outbreak, sequences from 148 base pair segment within VP1 amino terminal region were obtained for eight isolates an outbreak occurred North Bretagne (France). These compared themselves and with published 30 strains represented sub‐genotypes...
Abstract Background Influenza A virus (IAV) is a member of the family Orthomyxoviridae and contains eight segments single-stranded RNA genome with negative polarity. The first influenza pandemic this century was declared in April 2009, emergence novel H1N1 IAV strain (H1N1pdm) Mexico USA. Understanding extent causes biases codon usage essential to understanding viral evolution. comprehensive study investigate effect selection pressure imposed by human host on an emerging, trends involved...
Abstract It is widely accepted that the majority of cancers result from multiple cellular events leading to malignancy after a prolonged period clinical latency, and immune system plays critical role in control cancer progression. Bovine leukemia virus (BLV) an oncogenic member Retroviridae family. Complete genomic sequences BLV strains isolated peripheral blood mononuclear cells (PBMC) cattle have been previously reported. However, detailed characterization complete genome directly bovine...
On 30th January 2020, an outbreak of atypical pneumonia caused by a novel betacoronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was declared public health emergency international concern the World Health Organization. For this reason, detailed evolutionary analysis SARS-CoV-2 strains currently circulating in different geographic regions world performed. A compositional as well Bayesian coalescent complete genome sequences recently isolated Europe, North...
Bovine leukemia virus (BLV) is one of the five agents considered most significant for cattle. It important to determine prevalence and molecular epidemiology BLV throughout country in order gain a more thorough understanding current situation reveal possibility masked genotypes that primers used by OIE are unable identify. Blood samples were collected at random from 289 cows distributed 75 farms across country. PCR amplification env, gag tax gene segments was performed. The obtained...
The current highly pathogenic avian influenza H5N1 panzootic is having substantial impacts on wild birds and marine mammals. Following major widespread outbreaks in South America, an incursion to Antarctica occurred late the austral summer of 2023/2024 was confined region Antarctic Peninsula. To infer potential underlying processes, we compiled surveillance data from sub-Antarctic Islands prior first confirmed cases.
Genetic analysis of selected genome regions hepatitis A virus (HAV) suggested that distinct genotypes HAV could be found in different geographical regions. In order to gain insight into the genetic variability and mode evolution South America, an was performed sequence data obtained from VP1 amino terminus VP1/2A region strains isolated over a short period time Uruguay, Argentina Chile. Sequences 22 isolates were compared with published sequences 21 all world. Phylogenetic revealed belong...
Hepatitis C virus (HCV) has been the subject of intense research and clinical investigation as its major role in human disease emerged. Although homologous recombination demonstrated many members family Flaviviridae, to which HCV belongs, there have few studies reporting on natural populations HCV. Recombination break-points identified non structural proteins genome. Given implications that for RNA evolution, it is clearly important determine extent plays a evolution. In order gain insight...