A5048883235- SARS-CoV-2 and COVID-19 Research
- Chronic Lymphocytic Leukemia Research
- Hepatitis C virus research
- SARS-CoV-2 detection and testing
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Mosquito-borne diseases and control
- Animal Virus Infections Studies
- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Glycosylation and Glycoproteins Research
- Viral Infections and Immunology Research
- Liver Disease Diagnosis and Treatment
- Biochemical and Molecular Research
- Cancer survivorship and care
- Malaria Research and Control
- Childhood Cancer Survivors' Quality of Life
- HIV/AIDS drug development and treatment
- Plant Virus Research Studies
- RNA and protein synthesis mechanisms
- Lymphoma Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
Universidad de la República
2016-2025
Institut Pasteur de Montevideo
2010-2025
Hospital Maciel
2023
Universidad La República
2015-2022
University of Colombo
2021
Netherlands Food and Consumer Product Safety Authority
2021
National Institute for Public Health and the Environment
2021
Utrecht University
2021
Wageningen University & Research
2021
General Sir John Kotelawala Defence University
2021
Coxsackievirus B3 (CVB3), a member of the Enterovirus genus within Picornaviridae family, has emerged as key model for studying viral evolution and pathogenesis. Although traditionally considered obligate lytic viruses, recent research reveals that enteroviruses can also be released non-lytically extracellular vesicles (EVs). This study explores impact mutations at position 63 VP3 capsid protein on CVB3 fitness release mechanisms by substituting asparagine this with aromatic, charged,...
Abstract Background Influenza A virus (IAV) is a member of the family Orthomyxoviridae and contains eight segments single-stranded RNA genome with negative polarity. The first influenza pandemic this century was declared in April 2009, emergence novel H1N1 IAV strain (H1N1pdm) Mexico USA. Understanding extent causes biases codon usage essential to understanding viral evolution. comprehensive study investigate effect selection pressure imposed by human host on an emerging, trends involved...
Bovine leukemia virus (BLV) is one of the five agents considered most significant for cattle. It important to determine prevalence and molecular epidemiology BLV throughout country in order gain a more thorough understanding current situation reveal possibility masked genotypes that primers used by OIE are unable identify. Blood samples were collected at random from 289 cows distributed 75 farms across country. PCR amplification env, gag tax gene segments was performed. The obtained...
Since January 2020, the world is facing COVID-19 pandemic caused by SARS-CoV-2. In a big effort to cope with this outbreak, two Uruguayan institutions, Institut Pasteur de Montevideo and Universidad la República, have developed implemented diagnosis pipeline based on qRT-PCR using entirely local resources. context, we performed comparative quantitative proteomic analysis from oro- naso-pharyngeal swabs used for diagnosis. Tryptic peptides obtained five positive negative samples were analysed...
The current highly pathogenic avian influenza H5N1 panzootic is having substantial impacts on wild birds and marine mammals. Following major widespread outbreaks in South America, an incursion to Antarctica occurred late the austral summer of 2023/2024 was confined region Antarctic Peninsula. To infer potential underlying processes, we compiled surveillance data from sub-Antarctic Islands prior first confirmed cases.
Abstract Background/Aim Hepatitis C virus (HCV) infection is an important cause of morbidity and mortality in patients affected by hereditary bleeding disorders. HCV, as others RNA virus, exploit all possible mechanisms genetic variation to ensure their survival, such recombination mutation. In order gain insight into the variability HCV strains circulating hemophiliac patients, we have performed a phylogenetic analysis isolated from 10 with this kind pathology. Methods Putative recombinant...
The human genome contains a large number of endogenous retroviruses (HERVs). Their reactivation has frequently been observed in patients with cancer. Considering their role the carcinogenesis process, we aimed to study possible relationship between HERVs gene expression and Chronic Lymphocytic Leukemia (CLL). We focused on two viral genes gag np9, latter presumably an oncogene. found that transcriptional activity HERV-K np9 was greater CLL than healthy donors. However, not significantly...
ABSTRACT Background South America has become the new epicenter of COVID-19 pandemic with more than 1.1M reported cases and >50,000 deaths (June 2020). Conversely, Uruguay stands out as an outlier managing this health crisis remarkable success. Methods We developed a molecular diagnostic test to detect SARS-CoV-2. This methodology was transferred research institutes, public hospitals academic laboratories all around country, creating “ lab network ”. also implemented active epidemiological...
(1) To assess whether home blood pressure measurement is a reliable alternative to ambulatory monitoring for the evaluation of treated patients with inadequate control at clinic; and (2) evaluate relationship between several target-organ damage markers.A cross-sectional study was performed in 225 hypertensive persistently high values clinic (systolic 140 mmHg and/or diastolic 90 mmHg). All participants underwent measurement, 24-h monitoring. A subgroup following procedures: carotid...
Hepatitis C virus (HCV) has been the subject of intense research and clinical investigation as its major role in human disease emerged. HCV circulates vivo a complex population different but closely related viral variants, commonly referred to quasispecies. The extent which recombination plays evolution quasispecies when patients are undergoing anti-viral therapy is currently unknown. In order gain insight into these matters, we have performed phylogenetic analysis populations from six...
Host single-nucleotide polymorphisms (SNPs) near the interleukin 28B (IL28B) locus are associated with sustained virological response to antiviral therapy and spontaneous Hepatitis C Virus (HCV) clearance. Prevalence of these SNPs varies depending on ethnicity. The impact IL28B in HCV-infected patients is currently unknown Uruguay. Therefore, aim this study was evaluate compare distribution gene (rs12979860 rs8099917) among healthy individuals Uruguay thus assess their possible association...
We developed a genomic surveillance program for real-time monitoring of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants concern (VOCs) in Uruguay. report on PCR method SARS-CoV-2 VOCs, the workflow, and multiple independent introductions community transmission P.1 VOC
Among different prognostic factors in chronic lymphocytic leukemia (CLL), we previously demonstrated that lipoprotein lipase (LPL) is associated with an unmutated immunoglobulin profile and clinical poor outcome. Despite the usefulness of LPL for CLL prognosis, its functional role molecular mechanism regulating expression are still open questions. Interaction B-cells tissue microenvironment favors disease progression by promoting malignant B-cell growth. Since methylation can be altered...
Abstract The current highly pathogenic avian influenza H5N1 panzootic has substantial impacts on wild birds and marine mammals. Although major outbreaks occurred in South America, incursion to Antarctica emerged late the breeding season of 2023/2024 was confined wider region Antarctic Peninsula. To infer potential underlying processes, we compiled surveillance from Sub-Antarctic Islands prior first confirmed cases.
Hepatitis C Virus (HCV) infection treatment has dramatically changed with the advent of direct-acting antiviral agents (DAAs). However, efficacy DAAs can be attenuated by presence resistance-associated substitutions (RASs) before and after treatment. Indeed, RASs detected in DAA treatment-naïve HCV-infected patients could useful for clinical management outcome prediction. Although frequency naturally occurring HCV NS5A NS5B been addressed many countries, there are only a few reports on their...