A5023693531- Antioxidant Activity and Oxidative Stress
- Sirtuins and Resveratrol in Medicine
- Antibiotic Resistance in Bacteria
- Inflammation biomarkers and pathways
- Histone Deacetylase Inhibitors Research
- Atherosclerosis and Cardiovascular Diseases
- Free Radicals and Antioxidants
- Eicosanoids and Hypertension Pharmacology
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- SARS-CoV-2 and COVID-19 Research
- Genomics, phytochemicals, and oxidative stress
- Immune cells in cancer
- Neurogenetic and Muscular Disorders Research
- Adipokines, Inflammation, and Metabolic Diseases
- SARS-CoV-2 detection and testing
- Tryptophan and brain disorders
- Amyotrophic Lateral Sclerosis Research
- Inflammasome and immune disorders
- Bioactive Compounds and Antitumor Agents
- Calcium signaling and nucleotide metabolism
- Adipose Tissue and Metabolism
- COVID-19 Clinical Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
Institut Pasteur de Montevideo
2017-2023
Universidad de la República
2018
Instituto de Investigaciones Biológicas Clemente Estable
2017
ABSTRACT Background South America has become the new epicenter of COVID-19 pandemic with more than 1.1M reported cases and >50,000 deaths (June 2020). Conversely, Uruguay stands out as an outlier managing this health crisis remarkable success. Methods We developed a molecular diagnostic test to detect SARS-CoV-2. This methodology was transferred research institutes, public hospitals academic laboratories all around country, creating “ lab network ”. also implemented active epidemiological...
Acute and chronic inflammations are key homeostatic events in health disease. Sirtuins (SIRTs), a family of NAD-dependent protein deacylases, play pivotal role the regulation these inflammatory responses. Indeed, SIRTs have anti-inflammatory effects through myriad signaling cascades, including histone deacetylation gene silencing, p65/RelA inactivation, nucleotide‑binding oligomerization domain, leucine rich repeat, pyrin domain‑containing 3 inflammasome inhibition. Nevertheless, recent...
The second messenger c-di-GMP regulates the switch between motile and sessile bacterial lifestyles. A general feature of metabolism is presence a surprisingly large number genes coding for diguanylate cyclases phosphodiesterases, enzymes responsible its synthesis degradation respectively. However, physiological relevance this apparent redundancy not clear, emphasizing need investigating functions each these enzymes. Here we focused on phosphodiesterase PA2133 from Pseudomonas aeruginosa, an...
Chronic metabolic diseases, like obesity, type II diabetes and atherosclerosis often involve a low-grade sterile systemic inflammatory state, in which activation of the pro-inflammatory transcription factor NF-kB NLRP3 inflammasome play major role. It is well established that genetic inhibition ameliorates acute chronic inflammation. Indeed, accumulating experimental evidences murine models also humans suggest might be suitable approach to tackle deleterious effects diseases. In this work,...
Abstract Inflammation plays a major role in the onset and development of chronic non-communicable diseases like obesity, cardiovascular cancer. Combined, these represent most common causes death worldwide, thus novel pharmacological approaches is crucial. Electrophilic nitroalkenes derived from fatty acids are formed endogenously exert anti-inflammatory actions by modification proteins involved inflammation signaling cascades. We have developed α-tocopherol aiming to increase its salutary...
Background and purpose Atherosclerosis is characterized by chronic low‐grade inflammation with concomitant lipid accumulation in the arterial wall. Anti‐inflammatory anti‐atherogenic properties have been described for a novel class of endogenous nitroalkenes (nitrated‐unsaturated fatty acids), formed during digestion/absorption processes. The lipid‐associated antioxidant α‐tocopherol transported systemically LDL particles including to atheroma lesions. To capitalize on overlapping...
Emerging evidence suggests that immune receptors may participate in many aging-related processes such as energy metabolism, inflammation, and cognitive decline. CD300f, a TREM2-like lipid-sensing receptor, is an exceptional receptor it integrates activating inhibitory cell-signaling pathways modulate efferocytosis, microglial metabolic fitness. We hypothesize CD300f can regulate systemic ultimately healthy lifespan. closely followed several cohorts of two strains CD300f-/- WT mice both sexes...
The sirtuin 6 has emerged as a regulator of acute and chronic immune responses. Recent findings show that SIRT6 is necessary for mounting an active inflammatory response in macrophages. In vitro studies revealed stabilized the cytoplasm to promote tumor necrosis factor (TNFα) secretion. Notably, also promotes TNFα secretion by resident peritoneal macrophages upon lipopolysaccharide (LPS) stimulation vivo. Although many have investigated function through different genetic pharmacological...