A5067690142- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Immune cells in cancer
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Autophagy in Disease and Therapy
- Immune Response and Inflammation
- Inflammation biomarkers and pathways
- Calcium signaling and nucleotide metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
Institut Pasteur de Montevideo
2021-2023
Universidad de la República
2021-2022
Acute and chronic inflammations are key homeostatic events in health disease. Sirtuins (SIRTs), a family of NAD-dependent protein deacylases, play pivotal role the regulation these inflammatory responses. Indeed, SIRTs have anti-inflammatory effects through myriad signaling cascades, including histone deacetylation gene silencing, p65/RelA inactivation, nucleotide‑binding oligomerization domain, leucine rich repeat, pyrin domain‑containing 3 inflammasome inhibition. Nevertheless, recent...
Emerging evidence suggests that immune receptors may participate in many aging-related processes such as energy metabolism, inflammation, and cognitive decline. CD300f, a TREM2-like lipid-sensing receptor, is an exceptional receptor it integrates activating inhibitory cell-signaling pathways modulate efferocytosis, microglial metabolic fitness. We hypothesize CD300f can regulate systemic ultimately healthy lifespan. closely followed several cohorts of two strains CD300f-/- WT mice both sexes...
Abstract The protein Deleted in Breast Cancer 1 (DBC1), a regulator of several transcription factors and epigenetic modulators, plays determinant roles metabolism regulation, obesity aging-related processes. Knockout mice for Dbc1, develop morbid but are protected against liver steatosis, insulin resistance atherosclerosis. We have proposed that this healthy phenotype was mainly due to the expansion adipose tissue, avoiding free-fatty acid spillover metabolic damage peripheral tissues. To...
The sirtuin 6 has emerged as a regulator of acute and chronic immune responses. Recent findings show that SIRT6 is necessary for mounting an active inflammatory response in macrophages. In vitro studies revealed stabilized the cytoplasm to promote tumor necrosis factor (TNFα) secretion. Notably, also promotes TNFα secretion by resident peritoneal macrophages upon lipopolysaccharide (LPS) stimulation vivo. Although many have investigated function through different genetic pharmacological...