A5058581154- Hepatitis C virus research
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- SARS-CoV-2 detection and testing
- Mosquito-borne diseases and control
- MicroRNA in disease regulation
- Biochemical and Molecular Research
- Biomedical Text Mining and Ontologies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Chromosomal and Genetic Variations
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- HIV Research and Treatment
- Genomics and Phylogenetic Studies
- Antibiotics Pharmacokinetics and Efficacy
- CRISPR and Genetic Engineering
- Livestock and Poultry Management
- Virology and Viral Diseases
- Viral Infections and Outbreaks Research
- Pharmaceutical and Antibiotic Environmental Impacts
Universidad de la República
2014-2024
Institut Pasteur de Montevideo
2015-2024
Comisión Sectorial de Investigación Científica
2021
Creative Research Enterprises (United States)
2015-2021
Jackson and Tull (United States)
2021
Rockefeller University
2017
Universidad La República
2015
Institut Pasteur
2015
Centro Uruguayo de Imagenología Molecular
2014
Hepatitis C virus (HCV) requires the liver specific micro-RNA (miRNA), miR-122, to replicate. This was considered unique among RNA viruses until recent discoveries of HCV-related hepaciviruses prompting question a more general miR-122 dependence. Among hepaciviruses, closest known HCV relative is equine non-primate hepacivirus (NPHV). Here, we used Argonaute cross-linking immunoprecipitation (AGO-CLIP) confirm AGO binding single predicted site in NPHV 5'UTR vivo. To study requirements...
The human genome contains a large number of endogenous retroviruses (HERVs). Their reactivation has frequently been observed in patients with cancer. Considering their role the carcinogenesis process, we aimed to study possible relationship between HERVs gene expression and Chronic Lymphocytic Leukemia (CLL). We focused on two viral genes gag np9, latter presumably an oncogene. found that transcriptional activity HERV-K np9 was greater CLL than healthy donors. However, not significantly...
Abstract Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of large offline gold-standard benchmark documents that cover variety research fields such newly search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we established RElevant LIterature SearcH consortium consisting more than 1500 scientists from 84 countries, who collectively annotated...
We describe the first outbreak of Klebsiella pneumoniae carbapenemase-producing K. (KPC-KP), infection control measures adopted and shift in resistance patterns isolates during antibiotic treatment. The ST258 KPC-KP strain exhibited a multiresistant phenotype including co-resistance to gentamycin, colistin tigecycline intermediate susceptibility. Isolates before after treatment had different behaviour concerning their susceptibility population analysis profile study. A progressive increase...
Host single-nucleotide polymorphisms (SNPs) near the interleukin 28B (IL28B) locus are associated with sustained virological response to antiviral therapy and spontaneous Hepatitis C Virus (HCV) clearance. Prevalence of these SNPs varies depending on ethnicity. The impact IL28B in HCV-infected patients is currently unknown Uruguay. Therefore, aim this study was evaluate compare distribution gene (rs12979860 rs8099917) among healthy individuals Uruguay thus assess their possible association...
Background. Andes virus (ANDV) is the sole etiologic agent of hantavirus cardiopulmonary syndrome (HCPS) in Chile, with a fatality rate about 35%. Individual host factors affecting ANDV infection outcome are poorly understood. In this case-control genetic association analysis, we explored link between single-nucleotide polymorphisms (SNPs) rs12979860, rs8099917 and rs1800629 clinical ANDV-induced disease. The SNPs rs12979860 known to play role differential expression interleukin 28B gene...
Hepatitis C Virus (HCV) infection treatment has dramatically changed with the advent of direct-acting antiviral agents (DAAs). However, efficacy DAAs can be attenuated by presence resistance-associated substitutions (RASs) before and after treatment. Indeed, RASs detected in DAA treatment-naïve HCV-infected patients could useful for clinical management outcome prediction. Although frequency naturally occurring HCV NS5A NS5B been addressed many countries, there are only a few reports on their...
Hepatitis C virus (HCV) remains a significant global health challenge, affecting millions of people worldwide, with chronic infection persistent threat. Despite the advent direct-acting antivirals (DAAs), challenges in diagnosis and treatment remain, compounded by lack an effective vaccine. The HCV genome, characterized high genetic variability, consists eight distinct genotypes over ninety subtypes, underscoring complex dynamics within infected individuals. This study delves into intriguing...
Abstract Zika virus (ZIKV) is a member of the family Flaviviridae . In 2015, ZIKV triggered large epidemic in Brazil and spread across Latin America. November that year, Brazilian Ministry Health reported 20-fold increase cases neonatal microcephaly, which corresponds geographically temporally to outbreak. was isolated from brain tissue fetus diagnosed with recent studies mice models revealed infection may cause defects by influencing cell developments. Unfortunately, mechanisms alters...
Abstract Background Direct-Acting agents (DAAs) target and inhibit essential viral replication proteins. They have revolutionized the treatment of Hepatitis C virus (HCV) infection reaching high levels sustained virologic response. However, detection basal resistance-associated substitutions (RASs) to DAAs in naïve patients could be important predicting outcome some exhibiting failures DAA-based therapies. Therefore, aim this work was evaluate presence RASs as minority variants within...
Human endogenous retrovirus (HERVs) integrated in the human genome millions of years ago and became a stable part inherited genetic material.Most these HERVs are dysfunctional due to numerous mutations thus making it impossible generate full, infectious particle from single locus.However, many still exceptionally well preserved maintain Open Reading Frames encoding functional viral proteins.The permanence HERV´s genes along evolution suggests that elements have proven beneficial survival.In...
ABSTRACT The pandemic caused by SARS-CoV-2 has triggered an extraordinary collapse of healthcare systems and hundred thousand deaths worldwide. Following the declaration outbreak as a Public Health Emergency International Concern World Organization (WHO) on January 30 th , 2020, it become imperative to develop diagnostic tools reliably detect virus in infected patients. Several methods based real time reverse transcription polymerase chain reaction (RT-qPCR) for detection genomic RNA have...
The standard therapy for chronic hepatitis C infection is the combined treatment with pegylated interferon and ribavirin. Success in depends on both viral host factors. High costs, adverse drug effects poor clearance are existing challenges. Several studies have shown that response to antiviral links single nucleotide polymorphisms (SNP) interleukin (IL) 28B gene (1). aim of this study was evaluate these Uruguayan patients chronically infected virus (HCV), as a first approach personalized...