A5088788769- Cancer-related Molecular Pathways
- Osteoarthritis Treatment and Mechanisms
- Retinoids in leukemia and cellular processes
- Sarcoma Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Biomedical Text Mining and Ontologies
- Medical Imaging Techniques and Applications
- Chromatin Remodeling and Cancer
- Cancer Cells and Metastasis
- Hedgehog Signaling Pathway Studies
- Mesenchymal stem cell research
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Fibroblast Growth Factor Research
- Muscle Physiology and Disorders
- Bone Tumor Diagnosis and Treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Cutaneous Melanoma Detection and Management
- Topic Modeling
- Ferroptosis and cancer prognosis
- Histone Deacetylase Inhibitors Research
- Cell death mechanisms and regulation
- Renal cell carcinoma treatment
Erbe Elektromedizin (Germany)
2024
University of Tübingen
2010-2020
University of Freiburg
2018-2020
Natural and Medical Sciences Institute
2008-2010
Karlsruhe Institute of Technology
2009
FZI Research Center for Information Technology
2008
The p53 protein is one of the major tumor suppressor proteins. In response to DNA damage, prevented from degradation and accumulates high levels. Ionizing radiation leads hypophosphorylation ubiquitin ligase Mdm2 at sites where phosphorylation critical for activation Akt/PKB, a kinase that phosphorylates inhibits GSK-3. GSK-3, which normally Mdm2, inactivated in ionizing radiation. We show lymphoblasts patients with hereditary disorder ataxia telangiectasia despite absence functional ATM...
The Mdm2 oncoprotein regulates abundance and activity of the p53 tumor suppressor protein. For efficient degradation p53, needs to be phosphorylated at several contiguous residues within central conserved domain. We show that glycogen synthase kinase 3 (GSK-3) protein in vitro vivo Inhibition GSK-3 rescued from an Mdm2-dependent manner while its association with was not affected. Likewise, inhibition did alter localization or interaction MdmX. Ionizing radiation, which leads accumulation,...
The European Union multi-disciplinary Personalised RNA interference to Enhance the Delivery of Individualised Cytotoxic and Targeted therapeutics (PREDICT) consortium has recently initiated a framework accelerate development predictive biomarkers individual patient response anti-cancer agents. focuses on identification reliable approved agents with anti-angiogenic activity for which no exist: sunitinib, multi-targeted tyrosine kinase inhibitor everolimus, mammalian target rapamycin (mTOR)...
Breast conserving resection with free margins is the gold standard treatment for early breast cancer recommended by guidelines worldwide. Therefore, reliable discrimination between normal and malignant tissue at essential. In this study, abnormal samples from patients were characterized ex vivo optical emission spectroscopy (OES) based on ionized atoms molecules generated during electrosurgical treatment. The aim of study was to determine spectroscopic features which are typical healthy...
Using matrix elasticity and cyclic stretch have been investigated for inducing mesenchymal stromal cell (MSC) differentiation towards the smooth muscle (SMC) lineage but not in combination. We hypothesized that combining lineage-specific stiffness with would result a significantly increased expression of SMC markers, compared to non-stretched controls. First, we generated dense collagen type I sheets by mechanically compressing hydrogels. Atomic force microscopy revealed nanoscale range...
Rhabdomyosarcomas (RMS) are soft tissue tumours treated with a combination of surgery and chemotherapy. However, mortality rates remain high in case recurrences metastatic disease due to drug resistance failure undergo apoptosis. Therefore, innovative approaches targeting specific signalling pathways urgently needed. We analysed the impact different hedgehog (Hh) pathway inhibitors on growth survival six RMS cell lines using MTS assay, colony formation 3D spheroid cultures, flow cytometry...
Abstract Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of large offline gold-standard benchmark documents that cover variety research fields such newly search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we established RElevant LIterature SearcH consortium consisting more than 1500 scientists from 84 countries, who collectively annotated...
Rhabdomyosarcomas (RMS) are the most prevalent soft tissue sarcomas affecting children and adolescents. Despite intensive treatment consisting of multimodal chemotherapy surgery RMS patients diagnosed with metastatic disease expect long term survival rates only 20%. Often multidrug resistance arises upon initial response emphasizing need for new therapeutic drugs to improve efficiency. Previously, we demonstrated efficacy FDA approved drug arsenic trioxide (ATO) specifically inhibiting...
Ewing sarcomas (ES) are rare mesenchymal tumours, most commonly diagnosed in children and adolescents. Arsenic trioxide (ATO) has been shown to efficiently selectively target leukaemic blasts as well solid tumour cells. Since multidrug resistance often occurs recurrent metastatic ES, we tested potential additive effects of ATO combination with the cytostatic drugs etoposide doxorubicin. The sarcoma cell lines A673, RD-ES SK-N-MC stem cells (MSC) for control were treated ATO, doxorubicin...
Sclerosing spindle cell rhabdomyosarcoma (SSRMS) is a rare rhabdomyosarcomas (RMS) subtype. Especially cases bearing myogenic differentiation 1 (MYOD1) mutation are characterized by high recurrence and metastasis rate, often leading to fatal outcome. SSRMS lines valuable in vitro models for studying disease mechanisms the preclinical evaluation of new therapeutic approaches. In this study, line established from primary tumor 24-year-old female after multimodal chemotherapeutic pretreatment...
Zielsetzung: R0-Resektion ist nicht nur Goldstandard für die Behandlung von Mammakarzinom im Frühstadium, sondern auch prognostisch wertvoll. Für eine Bewertung des Resektionsrandes zuverlässige Unterscheidung zwischen normalem und malignem Gewebe obligat. Im Rahmen dieser Studie wurde Gewebedifferenzierung beim mithilfe optischer Emissionsspektroskopie (OES) Support-Vektor-Trainingsmethoden erprobt. Primäres Studienziel war Identifizierung spektroskopischer Merkmale, welche typisch gesundes...