A5028962640- Viral gastroenteritis research and epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- SARS-CoV-2 detection and testing
- Fecal contamination and water quality
- Virus-based gene therapy research
- Analytical Chemistry and Sensors
- Nanoparticle-Based Drug Delivery
- Tryptophan and brain disorders
- Viral Infectious Diseases and Gene Expression in Insects
- HIV Research and Treatment
- Gas Sensing Nanomaterials and Sensors
- Marine animal studies overview
- Fuel Cells and Related Materials
- Parasitic Diseases Research and Treatment
- Invertebrate Immune Response Mechanisms
- Advanced oxidation water treatment
- Cancer Research and Treatments
- Water Quality Monitoring and Analysis
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Respiratory viral infections research
- Aquaculture disease management and microbiota
University of Hawaiʻi at Mānoa
2011-2017
Nantong University
2012
University of Hawaii System
2011
The ability of monocytes and monocyte-derived macrophages (MDM) to travel towards chemotactic gradient, traverse tissue barriers, accumulate precisely at diseased sites makes them attractive candidates as drug carriers therapeutic gene delivery vehicles targeting the brain, where treatments are often hampered by blockade blood brain barrier (BBB). This study was designed fully establish an optimized cell-based system using MDM, evaluating their homing efficiency, engraftment potential, well...
Health risks associated with sewage-contaminated recreational waters are of important public health concern. Reliable water monitoring systems therefore crucial. Current quality criteria rely predominantly on the enumeration bacterial indicators, while potentially dangerous viral pathogens often remain undetected. Human enteric viruses have been proposed as alternative indicators; however, their detection is hindered by low concentrations present in environment. Reported here novel and...
The current criteria for recreational water quality evaluation are primarily based on measurements of fecal indicator bacteria growth. However, these often fail to predict the presence waterborne human pathogenic viruses. To explore possibility direct use enteric viruses as improved contamination indicators, adenovirus (HAdV) was tested a model in this study. In order establish highly sensitive protocol effective detection HAdV aquatic environments, sixteen published PCR primer sets were...
HIV-1 Tat is essential for HIV replication and also a well-known neurotoxic factor causing HIV-associated neurocognitive disorder (HAND). Currently, combined antiretroviral therapy targeting reverse transcriptase or protease cannot prevent the production of early viral proteins, especially Tat, once infection has been established. HIV-infected macrophages glial cells in brain still release into extracellular space where it can exert direct indirect neurotoxicity. Therefore, stable anti-Tat...
This study was aimed to explore the potential of a non-invasive monocytes-based delivery system transport therapeutic genes into diseased brain. The conducted by first establishing optimized conditions for lentiviral vector (LV)-mediated gene transfer freshly isolated monocytes, followed investigating inflamed-brain homing efficiency and in vivo cell-mediated transgene expression carrier monocytes mouse model with acute sub-regional neuroinflammation.Using newly spin-infection method, up 35%...
Purpose: Controlling and eliminating lymphatic filariasis will require further research of preventative measures implementation. Parasite is dependent on glycolysis for ATP production. The glycolytic enzyme glyceraldenyde-3-phosphate dehydrogenase (GAPDH) plays an important role in therefore either a potential target anti-parasite drug development or vaccine candidate. Therefore, we tried to investigate the DNA vaccine-elicited immune responses BALB/c mice. Materials Methods: We cloned gene...