A5102012360- Advanced Causal Inference Techniques
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Statistical Methods in Clinical Trials
- Bariatric Surgery and Outcomes
- Chronic Kidney Disease and Diabetes
- Diabetes Treatment and Management
- Cardiovascular Health and Disease Prevention
- Malaria Research and Control
- Gastric Cancer Management and Outcomes
- Liver Disease and Transplantation
- Viral gastroenteritis research and epidemiology
- Computational Drug Discovery Methods
- Hepatitis Viruses Studies and Epidemiology
- Esophageal and GI Pathology
- Natural Antidiabetic Agents Studies
- Meta-analysis and systematic reviews
- Optimal Experimental Design Methods
- Diet and metabolism studies
- Statistical Methods and Bayesian Inference
- Metastasis and carcinoma case studies
- Mosquito-borne diseases and control
- Health Systems, Economic Evaluations, Quality of Life
- Blood Pressure and Hypertension Studies
Takeda (United States)
2025
Texas Tech University
2024
University of Pittsburgh
2018-2021
Weatherford College
2020
Chengdu University of Traditional Chinese Medicine
2020
Obesity is linked to the development and progression of CKD, but whether bariatric surgery protects against CKD poorly understood. We, therefore, examined influences risk. The study included 2144 adults who underwent from March 2006 April 2009 participated in Longitudinal Assessment Bariatric Surgery-2 Study cohort. primary outcome was risk categories as assessed by Kidney Disease Improving Global Outcomes (KDIGO) consortium criteria using a combination eGFR albuminuria. Patients were 79%...
ABSTRACT Clinical trials are often designed based on limited information about effect sizes and precision parameters with risks of underpowered studies. This is more problematic for SMARTs where strategy effects sequences treatments. Sample size adjustment offers flexibility through re‐estimating sample during the trial to ensure adequate power at final analysis. While this adaptation common standard clinical trials, corresponding methods perform have not been adapted SMARTs. In paper, we...
Achieving HBsAg loss is an important landmark in the natural history of chronic hepatitis B (CHB). A more personalized approach to prediction relevant counseling patients. This study sought develop and validate a model for based on quantitative levels (qHBsAg) other baseline characteristics.The Hepatitis Research Network (HBRN) prospective cohort including 1240 untreated HBeAg-negative patients (1150 adults, 90 children) with median follow-up 5.5 years. Incidence rates surface antibody...
Background and Aims Hepatitis B virus (HBV) precore (PC) dual basal core promoter (BCP) mutations halt down‐regulate hepatitis e antigen (HBeAg) production respectively. PC mutation is rarely associated with HBV genotype A. We sought to examine the association of these variants genotypes, age, HBeAg status in a racially diverse population North America. Prospective study included 1,036 (808 adults, 228 children) participants Research Network. BCP were determined by Sanger sequencing,...
Hepatitis B e antigen (HBeAg) is a soluble viral protein in plasma of patients with hepatitis virus infection. HBeAg loss an important first stage clearance. We determined the rate and predictors North American cohort chronic infection (CHB). Among children adults CHB without HIV, HCV or HDV co-infection enrolled Research Network prospective studies, 819 were positive at their assessment (treatment naïve >24 weeks since treatment). Of these, 577 (200 children, 377 adults) followed every...
Sequential multiple assignment randomized trials (SMARTs) are systematic and efficient media for comparing dynamic treatment regimes (DTRs), where each patient is involved in stages of with the randomization at stage depending on patient's previous history interim outcomes. Generally, patients enrolled SMARTs equally to ethically acceptable options regardless how effective those treatments were during stages, which results some undesirable consequences practice, such as low recruitment, less...
Abstract Background Patients with chronic hepatitis B virus (HBV) may experience spontaneous biochemical flares of liver disease activity. This study aimed to determine (i) the prevalence prior and possible acute E (HEV) infection among persons HBV (ii) whether HEV is associated HBV. Methods Serum from a random sample 600 adults in Hepatitis Research Network Cohort Study was tested for RNA anti-HEV IgM IgG. Logistic regression models were used estimate crude adjusted odds ratios participant...
The prevalence of alcohol, tobacco, and coffee use association with liver health among North Americans Chronic Hepatitis B (CHB) infection has not been well described.
A sequential multiple assignment randomized trial (SMART) facilitates the comparison of adaptive treatment strategies (ATSs) simultaneously. Previous studies have established a framework to test homogeneity ATSs by global Wald through inverse probability weighting. SMARTs are generally lengthier than classical clinical trials due nature randomization in stages. Thus, it would be beneficial add interim analyses allowing for an early stop if overwhelming efficacy is observed. We introduce...
A sequential multiple assignment randomized trial (SMART) facilitates comparison of adaptive treatment strategies (ATSs) simultaneously. Previous studies have established a framework to test the homogeneity ATSs by global Wald through inverse probability weighting. SMARTs are generally lengthier than classical clinical trials due nature randomization in stages. Thus, it would be beneficial add interim analyses allowing for early stop if overwhelming efficacy is observed. We introduce group...
Objective To evaluate the application value of absorbable hemostat textile as submucosal injection endoscopic dissection (ESD). Methods Twelve New Zealand rabbits were injected with solution, glycerol fructose and normal saline. The uplift effect was measured after injection. Simulated ESD performed in rabbit stomach bleeding amount measured. site pathologically examined at 30 minutes soluble saline injected. Fifteen pigs two locations 20-30 cm from anus, another anus. One simulated...
Malaria remains a global health threat for centuries. In recent years, rising resistance of Plasmodium falciparum to current standard artemisinin-based combination therapies (ACTs) leads increasing treatment failures and requires optimized treatment. Here, we intend make systematic review meta-analysis optimizing malaria, so as find potential optimal