A5045086405- Neuroscience of respiration and sleep
- Genomics and Phylogenetic Studies
- Neuropeptides and Animal Physiology
- Nerve injury and regeneration
- Invertebrate Immune Response Mechanisms
- Neuroendocrine regulation and behavior
- Pain Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- Marine Bivalve and Aquaculture Studies
- Insect symbiosis and bacterial influences
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Genetics, Aging, and Longevity in Model Organisms
- Trigeminal Neuralgia and Treatments
- Neurobiology and Insect Physiology Research
- Bioinformatics and Genomic Networks
- Heart Rate Variability and Autonomic Control
- Phagocytosis and Immune Regulation
- CRISPR and Genetic Engineering
- High Altitude and Hypoxia
- Cellular transport and secretion
- Evolution and Genetic Dynamics
- Species Distribution and Climate Change
- Neonatal Respiratory Health Research
Harvard University
2022-2024
Boston University
2013-2021
Oregon Health & Science University
2008-2012
FlyBase provides a centralized resource for the genetic and genomic data of Drosophila melanogaster. As enters our fourth decade service to research community, we reflect on unique aspects look forward continued collaboration with larger model organism communities. In this study, emphasize dedicated reports tools have constructed meet specialized needs fly researchers but also facilitate use by other We highlight ways that support including an external resources page, help resources,...
Abstract FlyBase (flybase.org) is a model organism database and knowledge base about Drosophila melanogaster, commonly known as the fruit fly. Researchers from around world rely on genetic, genomic, functional information available in FlyBase, well its tools to view interrogate these data. In this article, we describe latest developments updates FlyBase. These include introduction of single-cell RNA sequencing data, improved content display information, updated orthology pipelines, new...
Functional characteristics of the arterial baroreceptor reflex change throughout ontogenesis, including perinatal adjustments gain and adult resetting during hypertension. However, cellular mechanisms that underlie these functional changes are not completely understood. Here, we provide evidence brain-derived neurotrophic factor (BDNF), a neurotrophin with well-established role in activity-dependent neuronal plasticity, is abundantly expressed vivo by large subset developing rat afferents....
Abstract Recent evidence indicates that endomorphins, endogenous mu‐opioid receptor (MOR) agonists, modulate synaptic transmission in both somatic and visceral sensory pathways. Here we show endomorphin‐2 (END‐2) is expressed newborn rat dorsal root ganglion (DRG) nodose‐petrosal complex (NPG) neurons, rarely co‐localizes with brain‐derived neurotrophic factor (BDNF). In order to examine activity‐dependent release of END‐2 from established a model using dispersed cultures DRG NPG cells...
Abstract Hypertension leads to structural and functional changes at baroreceptor synapses in the medial nucleus tractus solitarius (NTS), but underlying molecular mechanisms remain unknown. Our previous studies show that brain‐derived neurotrophic factor (BDNF) is abundantly expressed by rat nodose ganglion (NG) neurons, including afferents their central terminals NTS. We hypothesized hypertension upregulation of BDNF expression NG neurons. To test this hypothesis, we used two...
Abstract Programmed cell death and corpse clearance are an essential part of organismal health development. Cell corpses often cleared away by professional phagocytes such as macrophages. However, in certain tissues, neighboring cells known nonprofessional can also carry out functions. Here, we use the Drosophila melanogaster ovary to identify novel genes required for phagocytes. In ovary, germline die at multiple time points. As proceeds, epithelial follicle act facilitate these cells. We...
Brain‐derived neurotrophic factor (BDNF) is necessary and sufficient for the expression of long‐term facilitation, a form respiratory plasticity that induced by intermittent hypoxia (IH). BDNF target gene transcription methyl‐CpG‐binding protein 2 (MeCP2), but its role in determining regulation transcripts after IH has not been determined. MeCP2 null wild‐type male mice were exposed to three intervals (5 minutes 21% O , 5 8% ) followed 60‐minute post‐hypoxia rest. The ventral half cervical...