A5053586377- Pharmaceutical Economics and Policy
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmaceutical studies and practices
- Health Systems, Economic Evaluations, Quality of Life
- Nerve injury and regeneration
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Treatment of Major Depression
- Trigeminal Neuralgia and Treatments
- Tryptophan and brain disorders
- Vagus Nerve Stimulation Research
- Nutrition and Health Studies
- Bone health and osteoporosis research
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Pharmaceutical industry and healthcare
- Lipoproteins and Cardiovascular Health
- Pregnancy and Medication Impact
- Migraine and Headache Studies
- Electroconvulsive Therapy Studies
- Blood Pressure and Hypertension Studies
- Sex and Gender in Healthcare
- Microbial Metabolites in Food Biotechnology
- Attention Deficit Hyperactivity Disorder
- Axon Guidance and Neuronal Signaling
Medical University of Warsaw
2011-2025
European Medicines Agency
2021-2023
Centralny Szpital Kliniczny
2015
Oregon Health & Science University
2010-2013
Tumor necrosis factor (TNF) is considered a major proinflammatory cytokine, affecting various aspects of the immune reaction.All five TNF inhibitors currently available on market (i.e., etanercept, infliximab, adalimumab, certolizumab and golimumab) are top sellers, although indicated only in autoimmune diseases, including rheumatoid arthritis, Crohn's disease psoriasis.This article briefly discusses background place for modern therapy.The main safety inhibitor administration described...
It is well established that the majority of headache and other trigeminal nerve-associated disorders have higher prevalence in females than males. However, pathogenesis many chronic pain conditions, such as neuralgia, migraine temporo-mandibular disorders, still not known. One proposed mechanisms involve calcitonin gene-related peptide (CGRP), which considered most important neuropeptide system. In various animal models concentration CGRP has been shown to be increased ganglia (TG)....
Many data suggest involvement of inflammation in neurodegeneration. However, the exact mechanisms this cooperation are poorly understood. We have previously shown that induction inflammatory reaction, both before and after injury striatum, affects regeneration dopaminergic neurons. In present research we studied role reaction non-injured striatum. used myelin oligodendrocyte glycoprotein (MOG) 35-55 complete Freund’s adjuvant (CFA) to elicit experimental autoimmune encephalomyelitis (EAE)...
According to the World Health Organization (WHO), depressive disorders are currently considered as one of most disabling medical conditions in world with highest disability-adjusted life years [1] and this situation has apparently been further worsened during COVID-19 pandemic [2]. Up two thirds patients major (MDD) do not achieve full remission following an adequate first line standard care and/or experience residual symptoms such anxiety, impaired cognition, fatigue, sleep disturbance, or...
Monoamine oxidase (MAO) isoenzymes A and B are mitochondrial-bound proteins that catalyze the oxidative deamination of dietary amines monoamine transmitters. Others include: serotonin, epinephrine, 2-phenylethylamine, dopamine. MAOs can potentially modulate all processes involving bioactive amines, including regulation mood, emotional behavior, other brain function. MAO enzymatic activity plays a role in pathophysiology wide range mental neurodegenerative disorders, personality depressive...
The pathological process of neurodegeneration is accompanied by an inflammatory reaction that believed to contribute the pathogenesis neurodegenerative diseases. aim our study was evaluate influence autoimmune induced post-traumatic vaccination with myelin self-antigen on spontaneous regeneration dopaminergic neurons, injured MPTP. C57BL mice were intoxicated 40 mg/kg MPTP and seven days later immunized MOG 35-55 peptide in CFA. On 7th day following intoxication, treated showed decrease...