A5005236448- Inflammatory Bowel Disease
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Electrolyte and hormonal disorders
- Hemophilia Treatment and Research
- Ocular Diseases and Behçet’s Syndrome
- Blood groups and transfusion
- Antibiotics Pharmacokinetics and Efficacy
- Traumatic Brain Injury and Neurovascular Disturbances
- Microscopic Colitis
- Drug Transport and Resistance Mechanisms
- Glycosylation and Glycoproteins Research
- Biochemical effects in animals
- Food Quality and Safety Studies
- Chronic Lymphocytic Leukemia Research
- Occupational and environmental lung diseases
- Solar Energy Systems and Technologies
- Cardiac Valve Diseases and Treatments
- Veterinary Pharmacology and Anesthesia
- Veterinary medicine and infectious diseases
- S100 Proteins and Annexins
- Gastroesophageal reflux and treatments
- Adrenal Hormones and Disorders
- Carcinogens and Genotoxicity Assessment
- Head and Neck Surgical Oncology
Saitama Prefecture
2025
AbbVie (Japan)
2018-2020
ABB (Japan)
2018-2020
Keio University
1962-2013
Sapporo Kosei General Hospital
2013
Minamiaoyama Eye Clinic
2011
Tokyo Medical University
2011
Shiga University of Medical Science
2010
Teikyo University
2009
Kumamoto University
2006-2008
<h3>Background</h3> We investigated whether corpus atrophic gastritis worsens in Mongolian gerbils (MGs) after long-term administration of proton pump inhibitor (PPI). MGs are an excellent model for studying <i>Helicobacter pylori</i>-related and adenocarcinoma. <h3>Methods</h3> were separated into four groups (n =15/group); <i>H pylori</i> (ATCC43504) was inoculated the OPZ(omeprazole)+Hp (<i>H pylori</i>) Hp groups, a PPI (OPZ) administered to OPZ+Hp OPZ control group received no...
The safety and effectiveness of adalimumab was demonstrated in a phase 3 trial Japanese patients with intestinal Behçet's disease. aim this study to evaluate the long-term disease.This prospective, all-case, post-marketing conducted at 254 centers disease receiving adalimumab. primary endpoint incidence adverse drug reactions. Effectiveness endpoints included global improvement rating change C-reactive protein levels.Of 473 registered patients, 462 383 populations were administered for mean...
Cathepsin G is a serine protease secreted by activated neutrophils that play role in the inflammatory response. Because are known to be invading leukocytes various tumors, their products may influence characteristics of tumor cells such as growth state, motility, and adhesiveness between or extracellular matrix. Here, we demonstrate cathepsin induces cell-cell adhesion MCF-7 human breast cancer resulting from contact inhibition cell movement on fibronectin but not type IV collagen....
Adalimumab has been shown to induce and maintain clinical remission in patients with moderate severe ulcerative colitis (UC). However, no large-scale population-based studies have performed Japan. This study was conducted evaluate the safety effectiveness of adalimumab practice Japanese UC.In this 52-week, prospective, multicenter, single-cohort, noninterventional, observational, postmarketing surveillance study, UC received an initial subcutaneous injection 160 mg, followed by 80 mg at 2...
Crohn's disease is a chronic disorder; therefore, it essential to investigate long-term safety and efficacy of treatments. This study assessed the effectiveness adalimumab for up 3 years in Japanese patients with real-world settings.This was multicenter, single-cohort, observational disease. Safety assessments included incidence adverse drug reactions. Effectiveness clinical remission, mucosal healing, Work Productivity Activity Impairment (WPAI).The analysis populations comprised 389 310...
1. In two patiens suffering from urinary retention of various causes, appearance arrhythmias were seen at the time overdistension bladder, which promptly disappeared by emptying bladder catheterisation.2. Experimental in animals resulted transitory fall blood pressure, pictures coronary insufficiency EKG and/or arrhythmias. These changes relieving overdistension.3. guinea pigs it was shown that produced over-distension erased transection spinal cord between lumbar and sacral segment.4. Using...
This is a report on statistical study comparing the Kaup index and level of tobacco consumption patients with idiopathic spontaneous pneumothorax those healthy subjects. Astatistically significant difference was found between average that normal individuals in Japan as published by Ministry Health Welfare. A statistically also physical features 2, 433 males 1, 906 when compared means index. Again, noted Brinkmann The lower than subjects, while former higher. Idiopathic related to thin tall...
Abstract This study tested the hypothesis that determinants of mild liver injury are prerequisites for more severe idiosyncratic hepatotoxicity. verified whether possible risk factors rare valproic acid (VPA)-induced hepatotoxicity, VPA clearance and/or serum carnitine concentrations common to those a elevation in transaminases VPA-treated patients. was calculated 172 Japanese patients with epilepsy, using non-linear mixed-effects regression program. Carnitine were determined subset 60 The...
Organ weight and gross postmortem findings of control Fischer 344/DuCrj rats B6C3F1 mice are presented from subchronic, chronic toxicity carcinogenicity studies that were conducted over a 9 year period at our center (An-Pyo Center) . The mean organ the liver, kidney, spleen lung increased associated with age in both species. most common observed 109 weeks species thymic atrophy, enlargement spleen, dilation lumen uterus ovarian cysts. Male female commonly exhibited granular surface kidneys,...
To compare the cardiovascular effects of histamine H2 receptor antagonists, famotidine and cimetidine, in critically ill patients, seven ICU patients were given 20 mg or 200 cimetidine intravenously a randomized fashion. Each patient was studied on 2 separate days. In random fashion, they received one days other. Mean systemic arterial pressure (MAP) maximally decreased min after intravenous from 103 +/- 10 (13.7 1.3 kPa) (mean s.d.) to 83 15 mmHg (11.1 2.0 (P less than 0.05). MAP returned...
Both antidiuretic activity of the plasma and sodium-retaining urine from patients with edmatous diseases were assayed. The results obtained are as follows;Both plsma urinary increased in so-called secondary hyperaldosteronism.Some correlation between sodium output was found limited groups assayed, but no observed cirrhosis liver.In bioassay crude extracts some cases non-edematous patients, negative value, i.e. sodium-excreting activities obtained.On basis our findings, roles ADH aldosterone...
In order to develop an experimental technology employing fish embryonic stem (ES) cells, we attempted culture cells dissociated from blastula-stage embryos of the medaka (Oryzias latipes). Three types conditions were tested with regard medium, coating dishes or addition conditioned medium. Cells incubated for 1 day under each set transplanted into recipient examine whether they retained ability form chimeric fish, which was judged according body pigmentation. a control experiment in intact...
高齢眼科患者が鯉胆末加工食品を 1 ヶ月および 3 ヶ月間摂取した時の視覚機能に関する影響を検討した．被験者のアンケートによる自覚症状において，3 ヶ月摂取群において改善がみられたが，視力と眼圧については両群ともに改善はみられなかった．