A5017317709- Pancreatitis Pathology and Treatment
- Systemic Lupus Erythematosus Research
- Pancreatic and Hepatic Oncology Research
- Renal Transplantation Outcomes and Treatments
- Abdominal vascular conditions and treatments
- Hematopoietic Stem Cell Transplantation
- Mast cells and histamine
- Gastric Cancer Management and Outcomes
- Liver Diseases and Immunity
- Neuroendocrine Tumor Research Advances
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- Cytomegalovirus and herpesvirus research
- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Urticaria and Related Conditions
- Thyroid Cancer Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Abdominal Surgery and Complications
- CAR-T cell therapy research
- Whipple's Disease and Interleukins
- IgG4-Related and Inflammatory Diseases
- COVID-19 Clinical Research Studies
- Appendicitis Diagnosis and Management
- COVID-19 and healthcare impacts
Temple University
2024
University Hospitals of Cleveland
2020-2024
Temple University Hospital
2023
Case Western Reserve University
2020-2021
University Hospitals Cleveland Medical Center
2020-2021
Vanderbilt University
2018
Rush University Medical Center
2012-2013
Objectives Studies on the incidence of venous thromboembolism (VTE) in acute pancreatitis (AP) are scarce. We conducted a large database study to evaluate this relationship. Methods Data were extracted from electronic health record (Explorys; IBM Watson Health, Armonk, NY). identified patients with AP 2018 and 2019, analyzing VTE at 30 days after diagnosis AP. Univariate multivariate analyses performed identify risk factors associated VTE. Results A total 25,620 cases necrotizing (ANP)...
Mounting evidence supports a mechanistic association between irritable bowel syndrome (IBS) symptoms and mast cell hyperactivity. Yet, IBS disorders (MCDs) has not been studied. We examined this using two large databases verified with manual chart review.The IBM Watson Health Explorys database (Somers, NY), an aggregate of electronic health record (EHR) data from over dozen US healthcare systems, Epic's SlicerDicer tool, self-service tool containing de-identified the Epic EHR, were used to...
ABSTRACT Tumor necrosis factor-alpha inhibitors are not known to have significant liver toxicity; however, a few case reports state otherwise. We report the of 25-year-old man with Crohn's disease who was initiated on infliximab. The patient developed severe mixed hepatocellular and cholestatic injury that progressed into acute failure. Based clinical history, laboratory findings, histology, this presumed because development autoimmune hepatitis secondary He underwent transplantation....
Background Inpatient bowel preparation is often suboptimal. Few interventions have been effective at improving its success rate. We determined the clinical features associated with suboptimal inpatient and analyzed ability of an easily implementable set instructions inserted into electronic health record to improve preparation. Methods prospectively collected outcomes, demographics, for colonoscopies in a tertiary center from July November 2019, forming standard care (SOC) arm. After...
INTRODUCTION: Among a plethora of adverse effects attributable to drugs the TNF-α class, hepatotoxicity is rarely cited. We present case patient with Crohn’s disease (CD) who was started on infliximab and subsequently developed acute liver failure (ALF) necessitating transplant. CASE DESCRIPTION/METHODS: A 25-year-old male ileocolonic perianal CD methotrexate. Two months later, he reported anorexia weight loss after which methotrexate discontinued. Three initiation, onset pruritus, pale...
Phase II studies suggested that pts who received an in-vivo T-cell depleted (TCD) alloSCT with Alemtuzumab (AL) tended to have less aGVHD.However, the utility of this approach is limited by increased incidence mixed chimerism which associated disease recurrence and often require DLI. We hypothesize sub-optimal CD 34 +ve cell dose contribute after TCD using AL. By identifing optimal dose; protocol could maintain benefit lowering incidences GVHD minimize chimerism. also evaluate other patient...
Hypertension is one of the most common diagnoses carried by adults yet often difficult to manage. A combination medical therapy, patient engagement, and self-care required achieve blood pressure control. We, therefore, sought elicit views on lifestyle factors that are known influence optimal management hypertension. From outpatient clinics, we identified patients with documented hypertension taking at least antihypertensive medication. Patients secondary causes or end-organ damage were...
INTRODUCTION: There is increasing evidence that some patients with irritable bowel syndrome (IBS) have increased number of mast cells (MCs) or MC degranulation. Yet, association IBS primary (mast cell malignancy (MCM), mastocytosis (MA), activation (MCAS)) and secondary (chronic spontaneous urticaria (CSU)) disorders (MCDs) has not been studied. We investigated this using two large databases. METHODS: The Explorys database (Cleveland, OH) an aggregate de-identified electronic health record...
INTRODUCTION: Bowel prep is inadequate in one third of all inpatient colonoscopies. Inadequate intake bowel by inpatients may go unrecognized the gastroenterologist until procedure date, creating unnecessary delays and extending hospital admission and/or requiring repeat colonoscopy. We characterized patients with or incomplete prep, estimated burden to healthcare system suboptimal trialed an intervention improve quality prep. METHODS: prospectively collected outcomes, demographics clinical...
Introduction: Obstructive jaundice is a common presentation for primary pancreaticobiliary disease but, especially in the context of malignancy, metastatic should be considered. Here we present case patient with previously diagnosed malignancy presenting new jaundice. Case Description/Methods: A 70-year-old female medical history Stage IIIA1 high grade serous ovarian cancer and total abdominal hysterectomy bilateral salpingoopherectomy presented to hospital from oncology clinic abnormal...
Introduction: The differential diagnosis for vague generalized abdominal pain is extremely broad. Oftentimes, as gastroenterologists we tend to focus first and foremost on luminal GI pathology. Here present a rare cause of non-luminal, non-biliary Case Description/Methods: A 57-year-old man presented the hospital with chief complaint severe 3 weeks. He described discomfort, which was intermittent escalating over past 6 months. It associated malaise, fatigue, early satiety, anorexia,...