A5037429923- RNA Research and Splicing
- Polyomavirus and related diseases
- RNA regulation and disease
- Medical Imaging and Pathology Studies
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- T-cell and B-cell Immunology
Universität Ulm
2022-2024
Helmholtz Zentrum München
2022-2024
Target (United States)
2024
Pharmaceutical Biotechnology (Czechia)
2024
Acellera (Spain)
2024
Center for Integrated Protein Science Munich
2024
Technical University of Munich
2024
Institute of Molecular Biology
2024
Target (Germany)
2024
Drexel University
2018
Mutations in the human PURA gene cause neurodevelopmental syndrome. In contrast to several other monogenetic disorders, almost all reported mutations this nucleic acid-binding protein result full disease penetrance. study, we observed that patient across impair its previously co-localization with processing bodies. These either destroyed folding integrity, RNA binding, or dimerization of PURA. We also solved crystal structures N- and C-terminal PUR domains combined them molecular dynamics...
Treg cells modulate immune responses and can suppress the development of autoimmune diseases. Tumor necrosis factor receptor II (TNFRII) has been recognized as a key on these that facilitates expansion stabilization CD4+ cells. The purpose present study was to investigate therapeutic activity novel TNFRII agonist in experimental arthritis well role different cell subsets.A mouse TNFRII-selective fusion protein (EHD2-sc-mTNFR2 ) generated by genetic engineering. Mouse T were incubated...
Abstract The RNA-binding protein PURA has been implicated in the rare, monogenetic, neurodevelopmental disorder Syndrome. binds both DNA and RNA associated with various cellular functions. Only little is known about its main roles molecular pathways affected upon depletion. Here, we show that predominantly located cytoplasm, where it to thousands of mRNAs. Many these transcripts change abundance response encoded proteins suggest a role for immune responses, mitochondrial function, autophagy...
Mutations in the human PURA gene cause neurodevelopmental syndrome. In contrast to several other monogenetic disorders, almost all reported mutations this nucleic acid-binding protein result full disease penetrance. study, we observed that patient across impair its previously co-localization with processing bodies. These either destroyed folding integrity, RNA binding, or dimerization of PURA. We also solved crystal structures N- and C-terminal PUR domains combined them molecular dynamics...
Mutations in the human PURA gene cause neuro-developmental syndrome. In contrast to several other mono-genetic disorders, almost all reported mutations this nucleic acid binding protein result full disease penetrance. study, we observed that patient across impair its previously co-localization with processing bodies. These either destroyed folding integrity, RNA or dimerization of PURA. We also solved crystal structures N- and C-terminal PUR domains combined them molecular dynamics...
Mutations in the human PURA gene cause neuro-developmental syndrome. In contrast to several other mono-genetic disorders, almost all reported mutations this nucleic acid binding protein result full disease penetrance. study, we observed that patient across impair its previously co-localization with processing bodies. These either destroyed folding integrity, RNA or dimerization of PURA. We also solved crystal structures N- and C-terminal PUR domains combined them molecular dynamics...
Abstract Mutations in the human PURA gene cause neuro-developmental syndrome. In contrast to several other mono-genetic disorders, almost all reported mutations this nucleic acid binding protein result full disease penetrance. study, we observed that patient across impair its previously co-localization with processing bodies. These either destroyed folding integrity, RNA or dimerization of PURA. We also solved crystal structures N- and C-terminal PUR domains combined them molecular dynamics...
Abstract The RNA-binding protein PURA has been implicated in the rare, monogenetic, neurodevelopmental disorder Syndrome. binds both DNA and RNA associated with various cellular functions. Only little is known about its main roles molecular pathways affected upon depletion. Here, we show that predominantly located cytoplasm, where it to thousands of mRNAs. Many these transcripts change abundance response encoded proteins suggest a role for immune responses, mitochondrial function, autophagy...